U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

WDR74 WD repeat domain 74 [ Homo sapiens (human) ]

Gene ID: 54663, updated on 27-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
WDR74provided by HGNC
Official Full Name
WD repeat domain 74provided by HGNC
Primary source
HGNC:HGNC:25529
See related
Ensembl:ENSG00000133316 MIM:617947; AllianceGenome:HGNC:25529
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Nsa1
Summary
Involved in rRNA processing and ribosomal large subunit biogenesis. Located in nuclear exosome (RNase complex); nucleolus; and nucleoplasm. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in bone marrow (RPKM 9.1), ovary (RPKM 4.9) and 25 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See WDR74 in Genome Data Viewer
Location:
11q12.3
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (62832905..62841809, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (62822302..62831206, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (62600377..62609281, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene syntaxin 5 Neighboring gene RNA, U6 small nuclear 118, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4852 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4853 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4854 Neighboring gene STX5 divergent transcript Neighboring gene testis expressed 54 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4855 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4856 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4857 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4858 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4859 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3432 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:62608631-62609244 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:62609245-62609858 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:62609859-62610472 Neighboring gene RNA, U2 small nuclear 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4861 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4862 Neighboring gene small nucleolar RNA, C/D box 22 Neighboring gene small nucleolar RNA host gene 1 Neighboring gene small nucleolar RNA, C/D box 31

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. WDR74 serves as a novel therapeutic target by its oncogenic role in hepatocellular carcinoma. Gao F, et al. Pathol Res Pract, 2023 Aug. PMID 37331183
  2. WDR74 modulates melanoma tumorigenesis and metastasis through the RPL5-MDM2-p53 pathway. Li Y, et al. Oncogene, 2020 Mar. PMID 32005977
  3. WDR74 rs11231247 contributes to the susceptibility and prognosis of non-small cell lung cancer. Wu F, et al. Pathol Res Pract, 2023 Feb. PMID 36701849
  4. WDR74 induces nuclear β-catenin accumulation and activates Wnt-responsive genes to promote lung cancer growth and metastasis. Li Y, et al. Cancer Lett, 2020 Feb 28. PMID 31838084
  5. WDR74 functions as a novel coactivator in TGF-β signaling. Liu J, et al. J Genet Genomics, 2018 Dec 20. PMID 30594465

See all (64) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. WDR74 serves as a novel therapeutic target by its oncogenic role in hepatocellular carcinoma.
    Title: WDR74 serves as a novel therapeutic target by its oncogenic role in hepatocellular carcinoma.
  2. WDR74 rs11231247 contributes to the susceptibility and prognosis of non-small cell lung cancer.
    Title: WDR74 rs11231247 contributes to the susceptibility and prognosis of non-small cell lung cancer.
  3. WDR74 modulates melanoma tumorigenesis and metastasis through the RPL5-MDM2-p53 pathway.
    Title: WDR74 modulates melanoma tumorigenesis and metastasis through the RPL5-MDM2-p53 pathway.
  4. WDR74 induces nuclear beta-catenin accumulation and activates Wnt-responsive genes to promote lung cancer growth and metastasis.
    Title: WDR74 induces nuclear β-catenin accumulation and activates Wnt-responsive genes to promote lung cancer growth and metastasis.
  5. Through direct interactions with Smad proteins, WDR74 enhances TGF-beta-mediated phosphorylation and nuclear accumulation of Smad2 and Smad3.
    Title: WDR74 functions as a novel coactivator in TGF-β signaling.
  6. knockdown of WDR74 leads to significant defects in the pre-rRNA cleavage within the internal transcribed spacer 1, occurring in an early stage of the processing pathway. When the dissociation of WDR74 from the MTR4-containing exonuclease complex was impaired upon expression of mutant NVL2, the same processing defect, with partial migration of WDR74 from the nucleolus towards the nucleoplasm, was observed.
    Title: WDR74 participates in an early cleavage of the pre-rRNA processing pathway in cooperation with the nucleolar AAA-ATPase NVL2.
  7. results suggest that WDR74 is a novel regulatory protein of the MTR4-exsosome complex whose interaction is regulated by NVL2 and is involved in ribosome biogenesis
    Title: AAA-ATPase NVL2 acts on MTR4-exosome complex to dissociate the nucleolar protein WDR74.
Submit: New GeneRIF Correction

Phenotypes

Go to the top of the page Help

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • FLJ10439, FLJ21730

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in RNA metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in blastocyst formation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in rRNA processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ribosomal large subunit biogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ribosomal large subunit biogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of nuclear exosome (RNase complex) IDA
Inferred from Direct Assay
more info
 PubMed 
colocalizes_with nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of preribosome, large subunit precursor IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
WD repeat-containing protein 74
Names
NOP seven-associated protein 1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001307977.1 → NP_001294906.1  WD repeat-containing protein 74 isoform 2

    See identical proteins and their annotated locations for NP_001294906.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and lacks an in-frame exon in the 3' coding region compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
    Source sequence(s)
    AK001301, BC006351, BU740579
    Consensus CDS
    CCDS76421.1
    UniProtKB/TrEMBL
    E9PS41
    Related
    ENSP00000308931.7, ENST00000311713.11
    Conserved Domains (2) summary
    sd00039
    Location:45 → 85
    7WD40; WD40 repeat [structural motif]
    cl25539
    Location:45 → 302
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  2. NM_001369447.1 → NP_001356376.1  WD repeat-containing protein 74 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AP001160
    UniProtKB/TrEMBL
    E9PS41
    Conserved Domains (2) summary
    sd00039
    Location:45 → 85
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:45 → 316
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  3. NM_001369448.1 → NP_001356377.1  WD repeat-containing protein 74 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AP001160
    Conserved Domains (2) summary
    sd00039
    Location:52 → 90
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:7 → 167
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  4. NM_001369449.1 → NP_001356378.1  WD repeat-containing protein 74 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AP001160
    Conserved Domains (2) summary
    sd00039
    Location:52 → 90
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:7 → 167
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  5. NM_001369450.1 → NP_001356379.1  WD repeat-containing protein 74 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AP001160
    Consensus CDS
    CCDS44630.1
    UniProtKB/Swiss-Prot
    A8K8G5, Q6RFH5, Q9BRC9, Q9H6X8, Q9NVY2
    UniProtKB/TrEMBL
    E9PS41
    Related
    ENSP00000278856.4, ENST00000278856.9
    Conserved Domains (2) summary
    sd00039
    Location:45 → 85
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:45 → 302
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  6. NM_001369451.1 → NP_001356380.1  WD repeat-containing protein 74 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AP001160
    Consensus CDS
    CCDS44630.1
    UniProtKB/Swiss-Prot
    A8K8G5, Q6RFH5, Q9BRC9, Q9H6X8, Q9NVY2
    UniProtKB/TrEMBL
    E9PS41
    Related
    ENSP00000432119.1, ENST00000525239.5
    Conserved Domains (2) summary
    sd00039
    Location:45 → 85
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:45 → 302
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  7. NM_001369453.1 → NP_001356382.1  WD repeat-containing protein 74 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AP001160
    Consensus CDS
    CCDS44630.1
    UniProtKB/Swiss-Prot
    A8K8G5, Q6RFH5, Q9BRC9, Q9H6X8, Q9NVY2
    UniProtKB/TrEMBL
    E9PS41
    Related
    ENSP00000432113.1, ENST00000525752.5
    Conserved Domains (2) summary
    sd00039
    Location:45 → 85
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:45 → 302
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  8. NM_018093.3 → NP_060563.2  WD repeat-containing protein 74 isoform 1

    See identical proteins and their annotated locations for NP_060563.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK001301, AY500828, BC006351, BU740579
    Consensus CDS
    CCDS44630.1
    UniProtKB/Swiss-Prot
    A8K8G5, Q6RFH5, Q9BRC9, Q9H6X8, Q9NVY2
    UniProtKB/TrEMBL
    E9PS41
    Related
    ENSP00000435726.1, ENST00000529106.5
    Conserved Domains (2) summary
    sd00039
    Location:45 → 85
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:45 → 302
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RNA

  1. NR_161381.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AP001160

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    62832905..62841809 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    62822302..62831206 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6RFH5.1 GenPept UniProtKB/Swiss-Prot:Q6RFH5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools