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SYTL2 synaptotagmin like 2 [ Homo sapiens (human) ]

Gene ID: 54843, updated on 27-Nov-2024

Summary

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Official Symbol
SYTL2provided by HGNC
Official Full Name
synaptotagmin like 2provided by HGNC
Primary source
HGNC:HGNC:15585
See related
Ensembl:ENSG00000137501 MIM:612880; AllianceGenome:HGNC:15585
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EXO4; SLP2; SLP2A; SGA72M; CHR11SYT; PPP1R151
Summary
The protein encoded by this gene is a synaptotagmin-like protein (SLP) that belongs to a C2 domain-containing protein family. The SLP homology domain (SHD) of this protein has been shown to specifically bind the GTP-bound form of Ras-related protein Rab-27A (RAB27A). This protein plays a role in RAB27A-dependent vesicle trafficking and controls melanosome distribution in the cell periphery. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Jun 2009]
Expression
Broad expression in stomach (RPKM 22.4), colon (RPKM 16.3) and 17 other tissues See more
Orthologs
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Genomic context

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See SYTL2 in Genome Data Viewer
Location:
11q14.1
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (85694229..85854870, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (85630917..85791555, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (85405272..85565913, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5368 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5369 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5370 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:85383205-85383705 Neighboring gene CREB/ATF bZIP transcription factor Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:85396033-85396534 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:85396535-85397034 Neighboring gene coiled-coil domain containing 89 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr11:85472379-85473578 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3822 Neighboring gene coiled-coil domain containing 83 Neighboring gene adenosylhomocysteinase pseudogene 6 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:85646587-85647178 Neighboring gene solute carrier family 25 member 1 pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Double C2 protein. A review. Duncan RR, et al. Biochimie, 2000 May. PMID 10865129
  2. [Relationship between SLP-2 expression and prognosis in laryngeal squamous cell carcinoma and mammary invasive carcinoma]. Cao WF, et al. Zhonghua Bing Li Xue Za Zhi, 2010 May. PMID 20654157
  3. Synaptotagmin-like protein 2 gene promotes the metastatic potential in ovarian cancer. Sung HY, et al. Oncol Rep, 2016 Jul. PMID 27220283
  4. [Expression of SLP-2 protein in esophageal squamous cell carcinoma is associated with cancer invasion]. Cao WF, et al. Zhonghua Zhong Liu Za Zhi, 2010 Nov. PMID 21223688
  5. Synaptotagmin-like proteins control the formation of a single apical membrane domain in epithelial cells. Gálvez-Santisteban M, et al. Nat Cell Biol, 2012 Aug. PMID 22820376, Free PMC Article

See all (49) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Effects of COL1A1 and SYTL2 on inflammatory cell infiltration and poor extracellular matrix remodeling of the vascular wall in thoracic aortic aneurysm.
    Title: Effects of COL1A1 and SYTL2 on inflammatory cell infiltration and poor extracellular matrix remodeling of the vascular wall in thoracic aortic aneurysm.
  2. SYTL2 promotes metastasis of prostate cancer cells by enhancing FSCN1-mediated pseudopodia formation and invasion.
    Title: SYTL2 promotes metastasis of prostate cancer cells by enhancing FSCN1-mediated pseudopodia formation and invasion.
  3. Synaptotagmin-Like Protein 2a Regulates Angiogenic Lumen Formation via Weibel-Palade Body Apical Secretion of Angiopoietin-2.
    Title: Synaptotagmin-Like Protein 2a Regulates Angiogenic Lumen Formation via Weibel-Palade Body Apical Secretion of Angiopoietin-2.
  4. Overexpression of SYTL2 promoted metastatic potential.
    Title: Synaptotagmin-like protein 2 gene promotes the metastatic potential in ovarian cancer.
  5. SLP2 may play an important role in tumorigenesis of esophageal squamous cell carcinoma.
    Title: [Expression of SLP-2 protein in esophageal squamous cell carcinoma is associated with cancer invasion].
  6. A high expression level of SLP-2 may be associating with the development of invasion and metastasis in laryngeal squamous cell carcinoma and breast cancer.
    Title: [Relationship between SLP-2 expression and prognosis in laryngeal squamous cell carcinoma and mammary invasive carcinoma].
  7. Calmodulin suppresses synaptotagmin-2 transcription in cortical neurons
    Title: Calmodulin suppresses synaptotagmin-2 transcription in cortical neurons.
  8. Rab27a recruits Slp2a-hem on vesicular structures in peripheral CTLs and following CTL-target cell conjugate formation, the Slp2a-hem/Rab27a complex colocalizes with perforin-containing granules at the immunologic synapse
    Title: A newly identified isoform of Slp2a associates with Rab27a in cytotoxic T cells and participates to cytotoxic granule secretion.
  9. Rab27A/Slp2a expression in limb girdle muscular dystrophy 2B muscle provides a compensatory vesicular trafficking pathway that is able to repair membrane damage in the absence of dysferlin.
    Title: Dysferlin deficiency shows compensatory induction of Rab27A/Slp2a that may contribute to inflammatory onset.
  10. These results suggest that both Slp1 and Slp2-a may form part of a docking complex, capturing secretory lysosomes at the immunological synapse.
    Title: Slp1 and Slp2-a localize to the plasma membrane of CTL and contribute to secretion from the immunological synapse.
Submit: New GeneRIF Correction See all GeneRIFs (13)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction Pubs
Silencing of SLP2 by shRNA inhibits HIV-1 replication in Jurkat cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag SLP2 is a Rab27a effector required for HIV-1 Gag assembly at the plasma membrane in Jurkat cells PubMed
gag Silencing the expression of SLP2 leads to a diffuse intracellular HIV-1 Gag staining pattern accompanied by a dramatic reduction in the association of Gag with the plasma membrane PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ21219, FLJ34802, FLJ42764, FLJ45597, KIAA1597, MGC102768

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables neurexin family protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables neurexin family protein binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables phosphatase binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatidylinositol-4,5-bisphosphate binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables phosphatidylserine binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables small GTPase binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in exocytosis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in vesicle docking involved in exocytosis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in vesicle-mediated transport ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
is_active_in exocytic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in exocytic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in melanosome ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
synaptotagmin-like protein 2
Names
breast cancer-associated antigen SGA-72M
chromosome 11 synaptotagmin
exophilin-4
protein phosphatase 1, regulatory subunit 151

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029712.3 RefSeqGene

    Range
    48729..165641
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001162951.4 → NP_001156423.1  synaptotagmin-like protein 2 isoform g

    See identical proteins and their annotated locations for NP_001156423.1

    Status: REVIEWED

    Source sequence(s)
    AP000642, AP000974
    Consensus CDS
    CCDS53688.1
    UniProtKB/Swiss-Prot
    B3KRS3, B4DJT5, B4DKW3, B4DQ26, B7SA85, B7ZLX6, B7ZLX7, Q2YDA7, Q6TV07, Q6ZN59, Q6ZVC5, Q8ND34, Q96BJ2, Q9H768, Q9HCH5, Q9NXM1
    Conserved Domains (3) summary
    cd04020
    Location:769 → 925
    C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
    cl14603
    Location:629 → 756
    C2; C2 domain
    cl22851
    Location:5 → 41
    PHD_SF; PHD finger superfamily

  2. NM_001162952.3 → NP_001156424.1  synaptotagmin-like protein 2 isoform h

    See identical proteins and their annotated locations for NP_001156424.1

    Status: REVIEWED

    Source sequence(s)
    AP000642
    Consensus CDS
    CCDS53687.1
    Conserved Domains (2) summary
    cd04020
    Location:171 → 327
    C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
    cl14603
    Location:31 → 158
    C2; C2 domain

  3. NM_001162953.4 → NP_001156425.1  synaptotagmin-like protein 2 isoform i

    See identical proteins and their annotated locations for NP_001156425.1

    Status: REVIEWED

    Source sequence(s)
    AP000642, AP000974
    Consensus CDS
    CCDS53689.1
    UniProtKB/Swiss-Prot
    Q9HCH5
    Related
    ENSP00000318803.4, ENST00000316356.8
    Conserved Domains (3) summary
    cd04020
    Location:770 → 926
    C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
    cl14603
    Location:630 → 757
    C2; C2 domain
    cl22851
    Location:5 → 41
    PHD_SF; PHD finger superfamily

  4. NM_001289608.2 → NP_001276537.1  synaptotagmin-like protein 2 isoform j

    See identical proteins and their annotated locations for NP_001276537.1

    Status: REVIEWED

    Source sequence(s)
    AK124754, AK296224, EU035829
    Consensus CDS
    CCDS76461.1
    UniProtKB/Swiss-Prot
    Q9HCH5
    Related
    ENSP00000434010.1, ENST00000527523.5
    Conserved Domains (2) summary
    cd04020
    Location:737 → 893
    C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
    cl14603
    Location:597 → 724
    C2; C2 domain

  5. NM_001289609.2 → NP_001276538.1  synaptotagmin-like protein 2 isoform k

    Status: REVIEWED

    Source sequence(s)
    AP000642
    UniProtKB/Swiss-Prot
    Q9HCH5
    Conserved Domains (2) summary
    cd04020
    Location:90 → 246
    C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
    cl14603
    Location:14 → 77
    C2; C2 domain

  6. NM_001289610.2 → NP_001276539.1  synaptotagmin-like protein 2 isoform h

    See identical proteins and their annotated locations for NP_001276539.1

    Status: REVIEWED

    Source sequence(s)
    AP000642
    Consensus CDS
    CCDS53687.1
    Related
    ENSP00000432144.1, ENST00000533892.5
    Conserved Domains (2) summary
    cd04020
    Location:171 → 327
    C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
    cl14603
    Location:31 → 158
    C2; C2 domain

  7. NM_001365826.2 → NP_001352755.1  synaptotagmin-like protein 2 isoform l

    Status: REVIEWED

    Source sequence(s)
    AP000642, AP000974
    Conserved Domains (3) summary
    cd04020
    Location:746 → 902
    C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
    cl14603
    Location:606 → 733
    C2; C2 domain
    cl22851
    Location:5 → 41
    PHD_SF; PHD finger superfamily

  8. NM_001365827.2 → NP_001352756.1  synaptotagmin-like protein 2 isoform m

    Status: REVIEWED

    Source sequence(s)
    AP000642, AP000974
    Conserved Domains (2) summary
    cd04020
    Location:697 → 853
    C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
    cl14603
    Location:557 → 684
    C2; C2 domain

  9. NM_001365828.2 → NP_001352757.1  synaptotagmin-like protein 2 isoform b

    Status: REVIEWED

    Source sequence(s)
    AP000642
    Consensus CDS
    CCDS31652.1
    Related
    ENSP00000432996.1, ENST00000525702.5
    Conserved Domains (2) summary
    cd04020
    Location:211 → 367
    C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
    cl14603
    Location:71 → 198
    C2; C2 domain

  10. NM_001365829.2 → NP_001352758.1  synaptotagmin-like protein 2 isoform b

    Status: REVIEWED

    Source sequence(s)
    AP000642
    Consensus CDS
    CCDS31652.1
    Conserved Domains (2) summary
    cd04020
    Location:211 → 367
    C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
    cl14603
    Location:71 → 198
    C2; C2 domain

  11. NM_001365830.2 → NP_001352759.1  synaptotagmin-like protein 2 isoform b

    Status: REVIEWED

    Source sequence(s)
    AP000642
    Consensus CDS
    CCDS31652.1
    Conserved Domains (2) summary
    cd04020
    Location:211 → 367
    C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
    cl14603
    Location:71 → 198
    C2; C2 domain

  12. NM_001365831.2 → NP_001352760.1  synaptotagmin-like protein 2 isoform n

    Status: REVIEWED

    Source sequence(s)
    AP000642
    Conserved Domains (2) summary
    cd04020
    Location:160 → 316
    C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
    cl14603
    Location:20 → 147
    C2; C2 domain

  13. NM_001365832.2 → NP_001352761.1  synaptotagmin-like protein 2 isoform o

    Status: REVIEWED

    Source sequence(s)
    AP000642
    Conserved Domains (2) summary
    cd04020
    Location:103 → 259
    C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
    cl14603
    Location:20 → 92
    C2; C2 domain

  14. NM_001365833.2 → NP_001352762.1  synaptotagmin-like protein 2 isoform f

    Status: REVIEWED

    Source sequence(s)
    AP000642
    Consensus CDS
    CCDS41698.1
    Conserved Domains (2) summary
    cd04020
    Location:200 → 356
    C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
    cl14603
    Location:60 → 187
    C2; C2 domain

  15. NM_001365834.2 → NP_001352763.1  synaptotagmin-like protein 2 isoform p

    Status: REVIEWED

    Source sequence(s)
    AP000642
    Conserved Domains (2) summary
    cd04020
    Location:143 → 299
    C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
    cl14603
    Location:60 → 132
    C2; C2 domain

  16. NM_001365835.2 → NP_001352764.1  synaptotagmin-like protein 2 isoform q

    Status: REVIEWED

    Source sequence(s)
    AP000642
    Conserved Domains (2) summary
    cd04020
    Location:264 → 420
    C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
    cl14603
    Location:124 → 251
    C2; C2 domain

  17. NM_001394447.1 → NP_001381376.1  synaptotagmin-like protein 2 isoform r

    Status: REVIEWED

    Source sequence(s)
    AP000642, AP000974
    Conserved Domains (3) summary
    cd04020
    Location:2073 → 2229
    C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
    cl14603
    Location:1933 → 2060
    C2; C2 domain
    cl22851
    Location:5 → 41
    PHD_SF; PHD finger superfamily

  18. NM_001394448.1 → NP_001381377.1  synaptotagmin-like protein 2 isoform s

    Status: REVIEWED

    Source sequence(s)
    AP000642, AP000974
    Consensus CDS
    CCDS91568.1
    UniProtKB/TrEMBL
    A0A0U1RR07
    Related
    ENSP00000489269.1, ENST00000634661.1
    Conserved Domains (3) summary
    cd04020
    Location:2058 → 2214
    C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
    cl14603
    Location:1918 → 2045
    C2; C2 domain
    cl22851
    Location:5 → 41
    PHD_SF; PHD finger superfamily

  19. NM_001394449.1 → NP_001381378.1  synaptotagmin-like protein 2 isoform s

    Status: REVIEWED

    Source sequence(s)
    AP000642, AP000974
    Consensus CDS
    CCDS91568.1
    UniProtKB/TrEMBL
    A0A0U1RR07
    Conserved Domains (3) summary
    cd04020
    Location:2058 → 2214
    C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
    cl14603
    Location:1918 → 2045
    C2; C2 domain
    cl22851
    Location:5 → 41
    PHD_SF; PHD finger superfamily

  20. NM_001394450.1 → NP_001381379.1  synaptotagmin-like protein 2 isoform t

    Status: REVIEWED

    Source sequence(s)
    AP000642, AP000974
    Conserved Domains (2) summary
    cd04020
    Location:2031 → 2187
    C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
    cl14603
    Location:1891 → 2018
    C2; C2 domain

  21. NM_001394451.1 → NP_001381380.1  synaptotagmin-like protein 2 isoform u

    Status: REVIEWED

    Source sequence(s)
    AP000642, AP000974
    Conserved Domains (2) summary
    cd04020
    Location:2030 → 2186
    C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
    cl14603
    Location:1890 → 2017
    C2; C2 domain

  22. NM_001394452.1 → NP_001381381.1  synaptotagmin-like protein 2 isoform v

    Status: REVIEWED

    Source sequence(s)
    AP000642, AP000974
    Conserved Domains (1) summary
    cd04020
    Location:1870 → 2026
    C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4

  23. NM_001394453.1 → NP_001381382.1  synaptotagmin-like protein 2 isoform w

    Status: REVIEWED

    Source sequence(s)
    AP000642, AP000974
    Conserved Domains (3) summary
    cd04020
    Location:786 → 942
    C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
    cl14603
    Location:646 → 773
    C2; C2 domain
    cl22851
    Location:5 → 41
    PHD_SF; PHD finger superfamily

  24. NM_001394454.1 → NP_001381383.1  synaptotagmin-like protein 2 isoform w

    Status: REVIEWED

    Source sequence(s)
    AP000642, AP000974
    Conserved Domains (3) summary
    cd04020
    Location:786 → 942
    C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
    cl14603
    Location:646 → 773
    C2; C2 domain
    cl22851
    Location:5 → 41
    PHD_SF; PHD finger superfamily

  25. NM_001394455.1 → NP_001381384.1  synaptotagmin-like protein 2 isoform x

    Status: REVIEWED

    Source sequence(s)
    AP000642, AP000974
    Conserved Domains (3) summary
    cd04020
    Location:785 → 941
    C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
    cl14603
    Location:645 → 772
    C2; C2 domain
    cl22851
    Location:5 → 41
    PHD_SF; PHD finger superfamily

  26. NM_001394456.1 → NP_001381385.1  synaptotagmin-like protein 2 isoform x

    Status: REVIEWED

    Source sequence(s)
    AP000642, AP000974
    Conserved Domains (3) summary
    cd04020
    Location:785 → 941
    C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
    cl14603
    Location:645 → 772
    C2; C2 domain
    cl22851
    Location:5 → 41
    PHD_SF; PHD finger superfamily

  27. NM_001394457.1 → NP_001381386.1  synaptotagmin-like protein 2 isoform g

    Status: REVIEWED

    Source sequence(s)
    AP000642, AP000974
    Consensus CDS
    CCDS53688.1
    UniProtKB/Swiss-Prot
    B3KRS3, B4DJT5, B4DKW3, B4DQ26, B7SA85, B7ZLX6, B7ZLX7, Q2YDA7, Q6TV07, Q6ZN59, Q6ZVC5, Q8ND34, Q96BJ2, Q9H768, Q9HCH5, Q9NXM1
    Conserved Domains (3) summary
    cd04020
    Location:769 → 925
    C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
    cl14603
    Location:629 → 756
    C2; C2 domain
    cl22851
    Location:5 → 41
    PHD_SF; PHD finger superfamily

  28. NM_001394458.1 → NP_001381387.1  synaptotagmin-like protein 2 isoform g

    Status: REVIEWED

    Source sequence(s)
    AP000642, AP000974
    Consensus CDS
    CCDS53688.1
    UniProtKB/Swiss-Prot
    B3KRS3, B4DJT5, B4DKW3, B4DQ26, B7SA85, B7ZLX6, B7ZLX7, Q2YDA7, Q6TV07, Q6ZN59, Q6ZVC5, Q8ND34, Q96BJ2, Q9H768, Q9HCH5, Q9NXM1
    Conserved Domains (3) summary
    cd04020
    Location:769 → 925
    C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
    cl14603
    Location:629 → 756
    C2; C2 domain
    cl22851
    Location:5 → 41
    PHD_SF; PHD finger superfamily

  29. NM_001394459.1 → NP_001381388.1  synaptotagmin-like protein 2 isoform g

    Status: REVIEWED

    Source sequence(s)
    AP000642, AP000974
    Consensus CDS
    CCDS53688.1
    UniProtKB/Swiss-Prot
    B3KRS3, B4DJT5, B4DKW3, B4DQ26, B7SA85, B7ZLX6, B7ZLX7, Q2YDA7, Q6TV07, Q6ZN59, Q6ZVC5, Q8ND34, Q96BJ2, Q9H768, Q9HCH5, Q9NXM1
    Related
    ENSP00000431701.1, ENST00000528231.5
    Conserved Domains (3) summary
    cd04020
    Location:769 → 925
    C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
    cl14603
    Location:629 → 756
    C2; C2 domain
    cl22851
    Location:5 → 41
    PHD_SF; PHD finger superfamily

  30. NM_001394460.1 → NP_001381389.1  synaptotagmin-like protein 2 isoform y

    Status: REVIEWED

    Source sequence(s)
    AP000642, AP000974
    Conserved Domains (3) summary
    cd04020
    Location:759 → 915
    C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
    cl14603
    Location:619 → 746
    C2; C2 domain
    cl22851
    Location:5 → 41
    PHD_SF; PHD finger superfamily

  31. NM_001394461.1 → NP_001381390.1  synaptotagmin-like protein 2 isoform z

    Status: REVIEWED

    Source sequence(s)
    AP000642, AP000974
    Conserved Domains (2) summary
    cd04020
    Location:758 → 914
    C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
    cl14603
    Location:618 → 745
    C2; C2 domain

  32. NM_001394462.1 → NP_001381391.1  synaptotagmin-like protein 2 isoform aa

    Status: REVIEWED

    Source sequence(s)
    AP000642, AP000974
    Conserved Domains (2) summary
    cd04020
    Location:743 → 899
    C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
    cl14603
    Location:603 → 730
    C2; C2 domain

  33. NM_001394464.1 → NP_001381393.1  synaptotagmin-like protein 2 isoform bb

    Status: REVIEWED

    Source sequence(s)
    AP000642, AP000974
    Conserved Domains (2) summary
    cd04020
    Location:742 → 898
    C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
    cl14603
    Location:602 → 729
    C2; C2 domain

  34. NM_001394465.1 → NP_001381394.1  synaptotagmin-like protein 2 isoform cc

    Status: REVIEWED

    Source sequence(s)
    AP000642, AP000974
    Conserved Domains (2) summary
    cd04020
    Location:728 → 884
    C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
    cl14603
    Location:645 → 717
    C2; C2 domain

  35. NM_001394466.1 → NP_001381395.1  synaptotagmin-like protein 2 isoform dd

    Status: REVIEWED

    Source sequence(s)
    AP000642, AP000974
    Conserved Domains (2) summary
    cd04020
    Location:721 → 877
    C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
    cl14603
    Location:581 → 708
    C2; C2 domain

  36. NM_001394467.1 → NP_001381396.1  synaptotagmin-like protein 2 isoform ee

    Status: REVIEWED

    Source sequence(s)
    AP000642, AP000974
    Conserved Domains (2) summary
    cd04020
    Location:719 → 875
    C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
    cl14603
    Location:579 → 706
    C2; C2 domain

  37. NM_001394468.1 → NP_001381397.1  synaptotagmin-like protein 2 isoform ff

    Status: REVIEWED

    Source sequence(s)
    AP000642, AP000974
    Conserved Domains (2) summary
    cd04020
    Location:718 → 874
    C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
    cl14603
    Location:578 → 705
    C2; C2 domain

  38. NM_001394469.1 → NP_001381398.1  synaptotagmin-like protein 2 isoform gg

    Status: REVIEWED

    Source sequence(s)
    AP000642, AP000974
    Conserved Domains (2) summary
    cd04020
    Location:711 → 867
    C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
    cl14603
    Location:571 → 698
    C2; C2 domain

  39. NM_001394470.1 → NP_001381399.1  synaptotagmin-like protein 2 isoform hh

    Status: REVIEWED

    Source sequence(s)
    AP000642, AP000974
    Conserved Domains (2) summary
    cd04020
    Location:704 → 860
    C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
    cl14603
    Location:586 → 691
    C2; C2 domain

  40. NM_001394471.1 → NP_001381400.1  synaptotagmin-like protein 2 isoform ii

    Status: REVIEWED

    Source sequence(s)
    AP000642, AP000974
    Conserved Domains (2) summary
    cd04020
    Location:686 → 842
    C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
    cl14603
    Location:603 → 675
    C2; C2 domain

  41. NM_001394472.1 → NP_001381401.1  synaptotagmin-like protein 2 isoform ii

    Status: REVIEWED

    Source sequence(s)
    AP000642, AP000974
    Conserved Domains (2) summary
    cd04020
    Location:686 → 842
    C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
    cl14603
    Location:603 → 675
    C2; C2 domain

  42. NM_001394473.1 → NP_001381402.1  synaptotagmin-like protein 2 isoform jj

    Status: REVIEWED

    Source sequence(s)
    AP000642, AP000974
    Conserved Domains (3) summary
    cd04020
    Location:2047 → 2203
    C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
    cl14603
    Location:1907 → 2034
    C2; C2 domain
    cl22851
    Location:5 → 41
    PHD_SF; PHD finger superfamily

  43. NM_032943.5 → NP_116561.1  synaptotagmin-like protein 2 isoform a

    See identical proteins and their annotated locations for NP_116561.1

    Status: REVIEWED

    Source sequence(s)
    AB046817, AK124754, DC348081, EU035829
    Consensus CDS
    CCDS31649.1
    UniProtKB/Swiss-Prot
    Q9HCH5
    Related
    ENSP00000374610.4, ENST00000389960.8
    Conserved Domains (3) summary
    cd04020
    Location:745 → 901
    C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
    cl14603
    Location:605 → 732
    C2; C2 domain
    cl22851
    Location:5 → 41
    PHD_SF; PHD finger superfamily

  44. NM_206927.4 → NP_996810.2  synaptotagmin-like protein 2 isoform c

    Status: REVIEWED

    Source sequence(s)
    AP000642, AP000974
    Consensus CDS
    CCDS91569.1
    UniProtKB/TrEMBL
    A0A8J9FM55
    Related
    ENSP00000352065.7, ENST00000359152.10
    Conserved Domains (3) summary
    cd04020
    Location:2074 → 2230
    C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
    cl14603
    Location:1934 → 2061
    C2; C2 domain
    cl22851
    Location:5 → 41
    PHD_SF; PHD finger superfamily

  45. NM_206928.4 → NP_996811.2  synaptotagmin-like protein 2 isoform d

    Status: REVIEWED

    Source sequence(s)
    AP000642, AP000974
    Conserved Domains (3) summary
    cd04020
    Location:2057 → 2213
    C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
    cl14603
    Location:1917 → 2044
    C2; C2 domain
    cl22851
    Location:5 → 41
    PHD_SF; PHD finger superfamily

  46. NM_206929.4 → NP_996812.1  synaptotagmin-like protein 2 isoform b

    See identical proteins and their annotated locations for NP_996812.1

    Status: REVIEWED

    Source sequence(s)
    AP000642
    Consensus CDS
    CCDS31652.1
    Related
    ENSP00000435855.1, ENST00000529581.5
    Conserved Domains (2) summary
    cd04020
    Location:211 → 367
    C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
    cl14603
    Location:71 → 198
    C2; C2 domain

  47. NM_206930.4 → NP_996813.1  synaptotagmin-like protein 2 isoform f

    See identical proteins and their annotated locations for NP_996813.1

    Status: REVIEWED

    Source sequence(s)
    AP000642
    Consensus CDS
    CCDS41698.1
    Related
    ENSP00000374608.3, ENST00000389958.7
    Conserved Domains (2) summary
    cd04020
    Location:200 → 356
    C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
    cl14603
    Location:60 → 187
    C2; C2 domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    85694229..85854870 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047427166.1 → XP_047283122.1  synaptotagmin-like protein 2 isoform X14

  2. XM_047427162.1 → XP_047283118.1  synaptotagmin-like protein 2 isoform X10

  3. XM_047427158.1 → XP_047283114.1  synaptotagmin-like protein 2 isoform X6

  4. XM_047427174.1 → XP_047283130.1  synaptotagmin-like protein 2 isoform X22

  5. XM_047427168.1 → XP_047283124.1  synaptotagmin-like protein 2 isoform X16

  6. XM_017017934.2 → XP_016873423.1  synaptotagmin-like protein 2 isoform X1

  7. XM_047427171.1 → XP_047283127.1  synaptotagmin-like protein 2 isoform X19

  8. XM_047427173.1 → XP_047283129.1  synaptotagmin-like protein 2 isoform X21

  9. XM_047427161.1 → XP_047283117.1  synaptotagmin-like protein 2 isoform X9

  10. XM_047427175.1 → XP_047283131.1  synaptotagmin-like protein 2 isoform X23

  11. XM_047427167.1 → XP_047283123.1  synaptotagmin-like protein 2 isoform X15

  12. XM_047427164.1 → XP_047283120.1  synaptotagmin-like protein 2 isoform X12

  13. XM_047427170.1 → XP_047283126.1  synaptotagmin-like protein 2 isoform X18

  14. XM_047427156.1 → XP_047283112.1  synaptotagmin-like protein 2 isoform X4

  15. XM_047427155.1 → XP_047283111.1  synaptotagmin-like protein 2 isoform X3

  16. XM_047427163.1 → XP_047283119.1  synaptotagmin-like protein 2 isoform X11

  17. XM_047427169.1 → XP_047283125.1  synaptotagmin-like protein 2 isoform X17

  18. XM_047427172.1 → XP_047283128.1  synaptotagmin-like protein 2 isoform X20

  19. XM_047427165.1 → XP_047283121.1  synaptotagmin-like protein 2 isoform X13

  20. XM_047427153.1 → XP_047283109.1  synaptotagmin-like protein 2 isoform X2

  21. XM_047427157.1 → XP_047283113.1  synaptotagmin-like protein 2 isoform X5

  22. XM_047427176.1 → XP_047283132.1  synaptotagmin-like protein 2 isoform X25

  23. XM_017017939.2 → XP_016873428.1  synaptotagmin-like protein 2 isoform X24

  24. XM_011545116.3 → XP_011543418.1  synaptotagmin-like protein 2 isoform X26

    See identical proteins and their annotated locations for XP_011543418.1

    Conserved Domains (2) summary
    cd04020
    Location:160 → 316
    C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
    cl14603
    Location:20 → 147
    C2; C2 domain

  25. XM_047427159.1 → XP_047283115.1  synaptotagmin-like protein 2 isoform X7

  26. XM_047427160.1 → XP_047283116.1  synaptotagmin-like protein 2 isoform X8

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    85630917..85791555 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054369194.1 → XP_054225169.1  synaptotagmin-like protein 2 isoform X28

  2. XM_054369197.1 → XP_054225172.1  synaptotagmin-like protein 2 isoform X6

  3. XM_054369193.1 → XP_054225168.1  synaptotagmin-like protein 2 isoform X27

  4. XM_054369211.1 → XP_054225186.1  synaptotagmin-like protein 2 isoform X22

  5. XM_054369205.1 → XP_054225180.1  synaptotagmin-like protein 2 isoform X16

  6. XM_054369190.1 → XP_054225165.1  synaptotagmin-like protein 2 isoform X1

  7. XM_054369208.1 → XP_054225183.1  synaptotagmin-like protein 2 isoform X19

  8. XM_054369210.1 → XP_054225185.1  synaptotagmin-like protein 2 isoform X21

  9. XM_054369200.1 → XP_054225175.1  synaptotagmin-like protein 2 isoform X9

  10. XM_054369212.1 → XP_054225187.1  synaptotagmin-like protein 2 isoform X23

  11. XM_054369204.1 → XP_054225179.1  synaptotagmin-like protein 2 isoform X15

  12. XM_054369202.1 → XP_054225177.1  synaptotagmin-like protein 2 isoform X12

  13. XM_054369207.1 → XP_054225182.1  synaptotagmin-like protein 2 isoform X18

  14. XM_054369195.1 → XP_054225170.1  synaptotagmin-like protein 2 isoform X4

  15. XM_054369192.1 → XP_054225167.1  synaptotagmin-like protein 2 isoform X3

  16. XM_054369201.1 → XP_054225176.1  synaptotagmin-like protein 2 isoform X11

  17. XM_054369206.1 → XP_054225181.1  synaptotagmin-like protein 2 isoform X17

  18. XM_054369209.1 → XP_054225184.1  synaptotagmin-like protein 2 isoform X20

  19. XM_054369203.1 → XP_054225178.1  synaptotagmin-like protein 2 isoform X13

  20. XM_054369191.1 → XP_054225166.1  synaptotagmin-like protein 2 isoform X2

  21. XM_054369196.1 → XP_054225171.1  synaptotagmin-like protein 2 isoform X5

  22. XM_054369214.1 → XP_054225189.1  synaptotagmin-like protein 2 isoform X25

  23. XM_054369213.1 → XP_054225188.1  synaptotagmin-like protein 2 isoform X24

  24. XM_054369215.1 → XP_054225190.1  synaptotagmin-like protein 2 isoform X26

  25. XM_054369198.1 → XP_054225173.1  synaptotagmin-like protein 2 isoform X7

  26. XM_054369199.1 → XP_054225174.1  synaptotagmin-like protein 2 isoform X8

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_017695.1: Suppressed sequence

    Description
    NM_017695.1: This RefSeq record was removed by NCBI staff. Contact [email protected] for further information.

  2. NM_032379.3: Suppressed sequence

    Description
    NM_032379.3: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9HCH5.3 GenPept UniProtKB/Swiss-Prot:Q9HCH5

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