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SEMA4C semaphorin 4C [ Homo sapiens (human) ]

Gene ID: 54910, updated on 27-Nov-2024

Summary

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Official Symbol
SEMA4Cprovided by HGNC
Official Full Name
semaphorin 4Cprovided by HGNC
Primary source
HGNC:HGNC:10731
See related
Ensembl:ENSG00000168758 MIM:604462; AllianceGenome:HGNC:10731
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SEMAF; SEMAI; SEMACL1; M-SEMA-F
Summary
Predicted to enable chemorepellent activity and semaphorin receptor binding activity. Involved in muscle cell differentiation and positive regulation of stress-activated MAPK cascade. Located in extracellular space. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in placenta (RPKM 20.2), endometrium (RPKM 13.1) and 24 other tissues See more
Orthologs
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Genomic context

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See SEMA4C in Genome Data Viewer
Location:
2q11.2
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (96859718..96870830, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (97366349..97377098, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (97525455..97535817, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:97503619-97504173 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11779 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11780 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:97507205-97507810 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:97510949-97511138 Neighboring gene ankyrin repeat domain 23 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11781 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11782 Neighboring gene ankyrin repeat domain 39 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:97531745-97532406 Neighboring gene collagen alpha-1(I) chain-like Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11783 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11784 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11785 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11786 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11787 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11788 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:97538976-97539476 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16235 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16234 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:97540777-97541537 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:97541538-97542298 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:97547779-97548334 Neighboring gene family with sequence similarity 178 member B Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:97553339-97553894 Neighboring gene Sharpr-MPRA regulatory region 12522 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:97564470-97564614 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:97569425-97569924 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:97572409-97573004 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:97578973-97579660 Neighboring gene uncharacterized LOC101927053 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:97592729-97593442 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:97615759-97616400 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:97616401-97617040 Neighboring gene RNA, 5S ribosomal pseudogene 101

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Role of Sema4C in TGF-β1-induced mitogen-activated protein kinase activation and epithelial-mesenchymal transition in renal tubular epithelial cells. Zeng R, et al. Nephrol Dial Transplant, 2011 Apr. PMID 20959347, Free PMC Article
  2. High SEMA4C expression promotes the epithelial-mesenchymal transition and predicts poor prognosis in colorectal carcinoma. Hou Y, et al. Aging (Albany NY), 2020 Nov 7. PMID 33177246, Free PMC Article
  3. Semaphorin 4C Promotes Macrophage Recruitment and Angiogenesis in Breast Cancer. Yang J, et al. Mol Cancer Res, 2019 Oct. PMID 31308149
  4. Tumor-associated Lymphatic Endothelial Cells Promote Lymphatic Metastasis By Highly Expressing and Secreting SEMA4C. Wei JC, et al. Clin Cancer Res, 2017 Jan 1. PMID 27401250
  5. SEMA4C is a novel target to limit osteosarcoma growth, progression, and metastasis. Smeester BA, et al. Oncogene, 2020 Jan. PMID 31582836

See all (66) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Serum semaphorin4C as an auxiliary diagnostic biomarker for breast cancer.
    Title: Serum semaphorin4C as an auxiliary diagnostic biomarker for breast cancer.
  2. Effect of microrna-138 on epithelial-Mesenchymal transition and invasion of breast cancer cells by targeting semaphorin 4C.
    Title: Effect of microrna-138 on epithelial-Mesenchymal transition and invasion of breast cancer cells by targeting semaphorin 4C.
  3. High SEMA4C expression promotes the epithelial-mesenchymal transition and predicts poor prognosis in colorectal carcinoma.
    Title: High SEMA4C expression promotes the epithelial-mesenchymal transition and predicts poor prognosis in colorectal carcinoma.
  4. SEMA4C is a novel target to limit osteosarcoma growth, progression, and metastasis.
    Title: SEMA4C is a novel target to limit osteosarcoma growth, progression, and metastasis.
  5. Sema4C mediates EMT inducing chemotherapeutic resistance of miR-31-3p in cervical cancer cells.
    Title: Sema4C mediates EMT inducing chemotherapeutic resistance of miR-31-3p in cervical cancer cells.
  6. Downregulation of SEMA4C Inhibit Epithelial-Mesenchymal Transition (EMT) and the Invasion and Metastasis of Cervical Cancer Cells via Inhibiting Transforming Growth Factor-beta 1 (TGF-beta1)-Induced Hela cells p38 Mitogen-Activated Protein Kinase (MAPK) Activation.
    Title: Downregulation of SEMA4C Inhibit Epithelial-Mesenchymal Transition (EMT) and the Invasion and Metastasis of Cervical Cancer Cells via Inhibiting Transforming Growth Factor-beta 1 (TGF-β1)-Induced Hela cells p38 Mitogen-Activated Protein Kinase (MAPK) Activation.
  7. SEMA4C expression in breast cancer cells promotes cancer cell proliferation, macrophage recruitment, and angiogenesis.
    Title: Semaphorin 4C Promotes Macrophage Recruitment and Angiogenesis in Breast Cancer.
  8. Sema4D and 4C can contribute to tumor progression in human patients or experimental models, while the role of Sema4A has not yet been fully understood
    Title: Semaphorin 4A, 4C, and 4D: Function comparison in the autoimmunity, allergy, and cancer.
  9. data indicate that Sema4C/PlexinB2 signaling is essential for the growth of breast carcinoma cells, featuring a novel potential therapeutic target. In addition, elevated Sema4C expression enables indolent luminal-type tumors to become resistant to estrogen deprivation, invasive and metastatic in vivo
    Title: Sema4C/PlexinB2 signaling controls breast cancer cell growth, hormonal dependence and tumorigenic potential.
  10. Tumor-associated LECs produce sSEMA4C to promote lymphatic metastasis of tumors.
    Title: Tumor-associated Lymphatic Endothelial Cells Promote Lymphatic Metastasis By Highly Expressing and Secreting SEMA4C.
Submit: New GeneRIF Correction See all GeneRIFs (16)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ20369, KIAA1739, MGC126382, MGC126383

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables chemorepellent activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables neuropilin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables semaphorin receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell migration in hindbrain ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cerebellum development IEA
Inferred from Electronic Annotation
more info
  
involved_in muscle cell differentiation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neural crest cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neural tube closure ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of stress-activated MAPK cascade IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of postsynapse assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in semaphorin-plexin signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in semaphorin-plexin signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in extracellular space HDA PubMed 
located_in glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in postsynaptic density ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in postsynaptic density membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in synaptic vesicle membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in synaptic vesicle membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
semaphorin-4C
Names
M-Sema F
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017789.5 → NP_060259.4  semaphorin-4C precursor

    See identical proteins and their annotated locations for NP_060259.4

    Status: VALIDATED

    Source sequence(s)
    AC092636, BC017476, BC109104, BI518922
    Consensus CDS
    CCDS2029.1
    UniProtKB/Swiss-Prot
    Q32MJ3, Q7Z5X0, Q9C0C4
    Related
    ENSP00000306844.5, ENST00000305476.10
    Conserved Domains (3) summary
    cd11258
    Location:42 → 498
    Sema_4C; The Sema domain, a protein interacting module, of semaphorin 4C (Sema4C)
    smart00423
    Location:499 → 528
    PSI; domain found in Plexins, Semaphorins and Integrins
    cl11960
    Location:560 → 647
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    96859718..96870830 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047444831.1 → XP_047300787.1  semaphorin-4C isoform X1

    UniProtKB/Swiss-Prot
    Q32MJ3, Q7Z5X0, Q9C0C4

  2. XM_011511380.2 → XP_011509682.1  semaphorin-4C isoform X1

    See identical proteins and their annotated locations for XP_011509682.1

    UniProtKB/Swiss-Prot
    Q32MJ3, Q7Z5X0, Q9C0C4
    Conserved Domains (3) summary
    cd11258
    Location:42 → 498
    Sema_4C; The Sema domain, a protein interacting module, of semaphorin 4C (Sema4C)
    smart00423
    Location:499 → 528
    PSI; domain found in Plexins, Semaphorins and Integrins
    cl11960
    Location:560 → 647
    Ig; Immunoglobulin domain

  3. XM_011511381.2 → XP_011509683.1  semaphorin-4C isoform X1

    See identical proteins and their annotated locations for XP_011509683.1

    UniProtKB/Swiss-Prot
    Q32MJ3, Q7Z5X0, Q9C0C4
    Conserved Domains (3) summary
    cd11258
    Location:42 → 498
    Sema_4C; The Sema domain, a protein interacting module, of semaphorin 4C (Sema4C)
    smart00423
    Location:499 → 528
    PSI; domain found in Plexins, Semaphorins and Integrins
    cl11960
    Location:560 → 647
    Ig; Immunoglobulin domain

  4. XM_011511379.3 → XP_011509681.1  semaphorin-4C isoform X1

    See identical proteins and their annotated locations for XP_011509681.1

    UniProtKB/Swiss-Prot
    Q32MJ3, Q7Z5X0, Q9C0C4
    Conserved Domains (3) summary
    cd11258
    Location:42 → 498
    Sema_4C; The Sema domain, a protein interacting module, of semaphorin 4C (Sema4C)
    smart00423
    Location:499 → 528
    PSI; domain found in Plexins, Semaphorins and Integrins
    cl11960
    Location:560 → 647
    Ig; Immunoglobulin domain

  5. XM_011511378.3 → XP_011509680.1  semaphorin-4C isoform X1

    See identical proteins and their annotated locations for XP_011509680.1

    UniProtKB/Swiss-Prot
    Q32MJ3, Q7Z5X0, Q9C0C4
    Conserved Domains (3) summary
    cd11258
    Location:42 → 498
    Sema_4C; The Sema domain, a protein interacting module, of semaphorin 4C (Sema4C)
    smart00423
    Location:499 → 528
    PSI; domain found in Plexins, Semaphorins and Integrins
    cl11960
    Location:560 → 647
    Ig; Immunoglobulin domain

  6. XM_011511382.4 → XP_011509684.1  semaphorin-4C isoform X1

    See identical proteins and their annotated locations for XP_011509684.1

    UniProtKB/Swiss-Prot
    Q32MJ3, Q7Z5X0, Q9C0C4
    Conserved Domains (3) summary
    cd11258
    Location:42 → 498
    Sema_4C; The Sema domain, a protein interacting module, of semaphorin 4C (Sema4C)
    smart00423
    Location:499 → 528
    PSI; domain found in Plexins, Semaphorins and Integrins
    cl11960
    Location:560 → 647
    Ig; Immunoglobulin domain

  7. XM_011511383.2 → XP_011509685.1  semaphorin-4C isoform X1

    See identical proteins and their annotated locations for XP_011509685.1

    UniProtKB/Swiss-Prot
    Q32MJ3, Q7Z5X0, Q9C0C4
    Conserved Domains (3) summary
    cd11258
    Location:42 → 498
    Sema_4C; The Sema domain, a protein interacting module, of semaphorin 4C (Sema4C)
    smart00423
    Location:499 → 528
    PSI; domain found in Plexins, Semaphorins and Integrins
    cl11960
    Location:560 → 647
    Ig; Immunoglobulin domain

  8. XM_017004393.3 → XP_016859882.1  semaphorin-4C isoform X2

  9. XM_017004394.3 → XP_016859883.1  semaphorin-4C isoform X3

    Related
    ENST00000482925.5

  10. XM_047444832.1 → XP_047300788.1  semaphorin-4C isoform X4

  11. XM_047444834.1 → XP_047300790.1  semaphorin-4C isoform X4

  12. XM_006712606.4 → XP_006712669.2  semaphorin-4C isoform X4

    Conserved Domains (1) summary
    cd11258
    Location:42 → 480
    Sema_4C; The Sema domain, a protein interacting module, of semaphorin 4C (Sema4C)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    97366349..97377098 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054342672.1 → XP_054198647.1  semaphorin-4C isoform X1

    UniProtKB/Swiss-Prot
    Q32MJ3, Q7Z5X0, Q9C0C4

  2. XM_054342676.1 → XP_054198651.1  semaphorin-4C isoform X1

    UniProtKB/Swiss-Prot
    Q32MJ3, Q7Z5X0, Q9C0C4

  3. XM_054342674.1 → XP_054198649.1  semaphorin-4C isoform X1

    UniProtKB/Swiss-Prot
    Q32MJ3, Q7Z5X0, Q9C0C4

  4. XM_054342671.1 → XP_054198646.1  semaphorin-4C isoform X6

  5. XM_054342670.1 → XP_054198645.1  semaphorin-4C isoform X5

  6. XM_054342675.1 → XP_054198650.1  semaphorin-4C isoform X1

    UniProtKB/Swiss-Prot
    Q32MJ3, Q7Z5X0, Q9C0C4

  7. XM_054342673.1 → XP_054198648.1  semaphorin-4C isoform X1

    UniProtKB/Swiss-Prot
    Q32MJ3, Q7Z5X0, Q9C0C4

  8. XM_054342677.1 → XP_054198652.1  semaphorin-4C isoform X3

  9. XM_054342679.1 → XP_054198654.1  semaphorin-4C isoform X4

  10. XM_054342680.1 → XP_054198655.1  semaphorin-4C isoform X4

  11. XM_054342678.1 → XP_054198653.1  semaphorin-4C isoform X4

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9C0C4.2 GenPept UniProtKB/Swiss-Prot:Q9C0C4

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