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NMRK1 nicotinamide riboside kinase 1 [ Homo sapiens (human) ]

Gene ID: 54981, updated on 27-Nov-2024

Summary

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Official Symbol
NMRK1provided by HGNC
Official Full Name
nicotinamide riboside kinase 1provided by HGNC
Primary source
HGNC:HGNC:26057
See related
Ensembl:ENSG00000106733 MIM:608704; AllianceGenome:HGNC:26057
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NRK1; C9orf95; bA235O14.2
Summary
Nicotinamide adenine dinucleotide (NAD+) is essential for life in all organisms, both as a coenzyme for oxidoreductases and as a source of ADP-ribosyl groups used in various reactions. Nicotinic acid and nicotinamide, collectively known as niacin, are the vitamin precursors of NAD+. Nicotinamide riboside kinases, such as NRK1, function to synthesize NAD+ through nicotinamide mononucleotide using nicotinamide riboside as the precursor (Bieganowski and Brenner, 2004 [PubMed 15137942]).[supplied by OMIM, Mar 2008]
Expression
Ubiquitous expression in thyroid (RPKM 7.5), skin (RPKM 6.5) and 25 other tissues See more
Orthologs
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Genomic context

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See NMRK1 in Genome Data Viewer
Location:
9q21.13
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (75060577..75088155, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (87217117..87244685, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (77675493..77703071, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28468 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19951 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19952 Neighboring gene CARNMT1 antisense RNA 1 Neighboring gene chromosome 9 open reading frame 40 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:77579717-77580289 Neighboring gene carnosine N-methyltransferase 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28469 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28470 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19953 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19954 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19955 Neighboring gene osteoclast stimulating factor 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:77751669-77752168 Neighboring gene uncharacterized LOC105376090

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Crystal structure of human nicotinamide riboside kinase. Khan JA, et al. Structure, 2007 Aug. PMID 17698003
  2. NRK1 controls nicotinamide mononucleotide and nicotinamide riboside metabolism in mammalian cells. Ratajczak J, et al. Nat Commun, 2016 Oct 11. PMID 27725675, Free PMC Article
  3. Discoveries of nicotinamide riboside as a nutrient and conserved NRK genes establish a Preiss-Handler independent route to NAD+ in fungi and humans. Bieganowski P, et al. Cell, 2004 May 14. PMID 15137942
  4. Nicotinamide riboside kinase structures reveal new pathways to NAD+. Tempel W, et al. PLoS Biol, 2007 Oct 2. PMID 17914902, Free PMC Article
  5. DNA sequence and analysis of human chromosome 9. Humphray SJ, et al. Nature, 2004 May 27. PMID 15164053, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. nicotinamide riboside kinase 1 (NRK1) is necessary and rate-limiting for the use of exogenous nicotinamide riboside and nicotinamide mononucleotide for NAD(+) synthesis.
    Title: NRK1 controls nicotinamide mononucleotide and nicotinamide riboside metabolism in mammalian cells.
  2. Crystal structure of NRK1 is reported.
    Title: Crystal structure of human nicotinamide riboside kinase.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ20559

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nicotinate riboside kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ribosylnicotinamide kinase activity EXP
Inferred from Experiment
more info
 PubMed 
enables ribosylnicotinamide kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ribosylnicotinate kinase activity EXP
Inferred from Experiment
more info
 PubMed 
Process Evidence Code Pubs
involved_in NAD biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in NAD metabolic process TAS
Traceable Author Statement
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
nicotinamide riboside kinase 1
Names
NRK 1
RNK 1
nicotinic acid riboside kinase 1
nmR-K 1
ribosylnicotinamide kinase 1
ribosylnicotinic acid kinase 1
NP_001121075.1
NP_001317607.1
NP_001317608.1
NP_060351.1
XP_006717226.1
XP_011517119.1
XP_016870357.1
XP_016870359.1
XP_016870363.1
XP_047279503.1
XP_047279504.1
XP_047279505.1
XP_047279506.1
XP_054219165.1
XP_054219166.1
XP_054219167.1
XP_054219168.1
XP_054219169.1
XP_054219170.1
XP_054219171.1
XP_054219172.1
XP_054219173.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001127603.2 → NP_001121075.1  nicotinamide riboside kinase 1 isoform 2

    See identical proteins and their annotated locations for NP_001121075.1

    Status: VALIDATED

    Source sequence(s)
    AL133548, BC036804
    Consensus CDS
    CCDS47981.1
    UniProtKB/TrEMBL
    B3KUG3
    Related
    ENSP00000366004.4, ENST00000376808.8
    Conserved Domains (1) summary
    cd02024
    Location:5 → 136
    NRK1; Nicotinamide riboside kinase (NRK) is an enzyme involved in the metabolism of nicotinamide adenine dinucleotide (NAD+). This enzyme catalyzes the phosphorylation of nicotinamide riboside (NR) to form nicotinamide mononucleotide (NMN). It defines the NR ...

  2. NM_001330678.2 → NP_001317607.1  nicotinamide riboside kinase 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AA412267, AK097144, AL133548, BC036804, CA440629
    Consensus CDS
    CCDS83374.1
    UniProtKB/TrEMBL
    B3KUG3, Q5W125
    Related
    ENSP00000366007.1, ENST00000376811.5
    Conserved Domains (1) summary
    cd02024
    Location:12 → 164
    NRK1; Nicotinamide riboside kinase (NRK) is an enzyme involved in the metabolism of nicotinamide adenine dinucleotide (NAD+). This enzyme catalyzes the phosphorylation of nicotinamide riboside (NR) to form nicotinamide mononucleotide (NMN). It defines the NR ...

  3. NM_001330679.2 → NP_001317608.1  nicotinamide riboside kinase 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AA412267, AK097144, AL133548, AL555401, BE502779, CA440629
    Consensus CDS
    CCDS83374.1
    UniProtKB/TrEMBL
    B3KUG3, Q5W125
    Conserved Domains (1) summary
    cd02024
    Location:12 → 164
    NRK1; Nicotinamide riboside kinase (NRK) is an enzyme involved in the metabolism of nicotinamide adenine dinucleotide (NAD+). This enzyme catalyzes the phosphorylation of nicotinamide riboside (NR) to form nicotinamide mononucleotide (NMN). It defines the NR ...

  4. NM_017881.3 → NP_060351.1  nicotinamide riboside kinase 1 isoform 1

    See identical proteins and their annotated locations for NP_060351.1

    Status: VALIDATED

    Source sequence(s)
    AK000566, AL133548, BC036804
    Consensus CDS
    CCDS6650.1
    UniProtKB/Swiss-Prot
    Q5W124, Q8N430, Q9NWW6
    UniProtKB/TrEMBL
    B3KUG3
    Related
    ENSP00000354387.4, ENST00000361092.9
    Conserved Domains (1) summary
    cd02024
    Location:5 → 160
    NRK1; Nicotinamide riboside kinase (NRK) is an enzyme involved in the metabolism of nicotinamide adenine dinucleotide (NAD+). This enzyme catalyzes the phosphorylation of nicotinamide riboside (NR) to form nicotinamide mononucleotide (NMN). It defines the NR ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    75060577..75088155 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017014874.2 → XP_016870363.1  nicotinamide riboside kinase 1 isoform X4

    UniProtKB/TrEMBL
    B3KUG3
    Conserved Domains (1) summary
    cd02024
    Location:5 → 136
    NRK1; Nicotinamide riboside kinase (NRK) is an enzyme involved in the metabolism of nicotinamide adenine dinucleotide (NAD+). This enzyme catalyzes the phosphorylation of nicotinamide riboside (NR) to form nicotinamide mononucleotide (NMN). It defines the NR ...

  2. XM_006717163.3 → XP_006717226.1  nicotinamide riboside kinase 1 isoform X2

    See identical proteins and their annotated locations for XP_006717226.1

    UniProtKB/Swiss-Prot
    Q5W124, Q8N430, Q9NWW6
    UniProtKB/TrEMBL
    B3KUG3
    Conserved Domains (1) summary
    cd02024
    Location:5 → 160
    NRK1; Nicotinamide riboside kinase (NRK) is an enzyme involved in the metabolism of nicotinamide adenine dinucleotide (NAD+). This enzyme catalyzes the phosphorylation of nicotinamide riboside (NR) to form nicotinamide mononucleotide (NMN). It defines the NR ...

  3. XM_047423548.1 → XP_047279504.1  nicotinamide riboside kinase 1 isoform X1

    UniProtKB/TrEMBL
    Q5W125

  4. XM_017014868.2 → XP_016870357.1  nicotinamide riboside kinase 1 isoform X1

    UniProtKB/TrEMBL
    B3KUG3, Q5W125
    Conserved Domains (1) summary
    cd02024
    Location:12 → 164
    NRK1; Nicotinamide riboside kinase (NRK) is an enzyme involved in the metabolism of nicotinamide adenine dinucleotide (NAD+). This enzyme catalyzes the phosphorylation of nicotinamide riboside (NR) to form nicotinamide mononucleotide (NMN). It defines the NR ...

  5. XM_047423549.1 → XP_047279505.1  nicotinamide riboside kinase 1 isoform X2

    UniProtKB/Swiss-Prot
    Q5W124, Q8N430, Q9NWW6

  6. XM_017014870.3 → XP_016870359.1  nicotinamide riboside kinase 1 isoform X2

    UniProtKB/Swiss-Prot
    Q5W124, Q8N430, Q9NWW6
    UniProtKB/TrEMBL
    B3KUG3
    Conserved Domains (1) summary
    cd02024
    Location:5 → 160
    NRK1; Nicotinamide riboside kinase (NRK) is an enzyme involved in the metabolism of nicotinamide adenine dinucleotide (NAD+). This enzyme catalyzes the phosphorylation of nicotinamide riboside (NR) to form nicotinamide mononucleotide (NMN). It defines the NR ...

  7. XM_047423547.1 → XP_047279503.1  nicotinamide riboside kinase 1 isoform X1

    UniProtKB/TrEMBL
    Q5W125

  8. XM_011518817.2 → XP_011517119.1  nicotinamide riboside kinase 1 isoform X1

    See identical proteins and their annotated locations for XP_011517119.1

    UniProtKB/TrEMBL
    B3KUG3, Q5W125
    Conserved Domains (1) summary
    cd02024
    Location:12 → 164
    NRK1; Nicotinamide riboside kinase (NRK) is an enzyme involved in the metabolism of nicotinamide adenine dinucleotide (NAD+). This enzyme catalyzes the phosphorylation of nicotinamide riboside (NR) to form nicotinamide mononucleotide (NMN). It defines the NR ...

  9. XM_047423550.1 → XP_047279506.1  nicotinamide riboside kinase 1 isoform X3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    87217117..87244685 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054363198.1 → XP_054219173.1  nicotinamide riboside kinase 1 isoform X4

  2. XM_054363194.1 → XP_054219169.1  nicotinamide riboside kinase 1 isoform X2

    UniProtKB/Swiss-Prot
    Q5W124, Q8N430, Q9NWW6

  3. XM_054363193.1 → XP_054219168.1  nicotinamide riboside kinase 1 isoform X1

    UniProtKB/TrEMBL
    Q5W125

  4. XM_054363192.1 → XP_054219167.1  nicotinamide riboside kinase 1 isoform X1

    UniProtKB/TrEMBL
    Q5W125

  5. XM_054363196.1 → XP_054219171.1  nicotinamide riboside kinase 1 isoform X2

    UniProtKB/Swiss-Prot
    Q5W124, Q8N430, Q9NWW6

  6. XM_054363195.1 → XP_054219170.1  nicotinamide riboside kinase 1 isoform X2

    UniProtKB/Swiss-Prot
    Q5W124, Q8N430, Q9NWW6

  7. XM_054363191.1 → XP_054219166.1  nicotinamide riboside kinase 1 isoform X1

    UniProtKB/TrEMBL
    Q5W125

  8. XM_054363190.1 → XP_054219165.1  nicotinamide riboside kinase 1 isoform X1

    UniProtKB/TrEMBL
    Q5W125

  9. XM_054363197.1 → XP_054219172.1  nicotinamide riboside kinase 1 isoform X3

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NR_023352.1: Suppressed sequence

    Description
    NR_023352.1: This RefSeq was removed because it is now thought that this transcript encodes a protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NWW6.1 GenPept UniProtKB/Swiss-Prot:Q9NWW6

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