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babam2 BRISC and BRCA1 A complex member 2 [ Danio rerio (zebrafish) ]

Gene ID: 550474, updated on 4-Jan-2025

Summary

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Official Symbol
babam2provided by ZNC
Official Full Name
BRISC and BRCA1 A complex member 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-050417-299
See related
Ensembl:ENSDARG00000038863 AllianceGenome:ZFIN:ZDB-GENE-050417-299
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
bre; im:7141046; zgc:110368
Summary
Predicted to enable polyubiquitin modification-dependent protein binding activity. Predicted to be involved in several processes, including mitotic G2 DNA damage checkpoint signaling; positive regulation of DNA repair; and response to ionizing radiation. Predicted to act upstream of or within DNA repair. Predicted to be located in cytoplasm and nucleus. Predicted to be part of BRCA1-A complex and BRISC complex. Orthologous to human BABAM2 (BRISC and BRCA1 A complex member 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
human mouse all
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Genomic context

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See babam2 in Genome Data Viewer
Location:
chromosome: 17
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 17 NC_007128.7 (41081997..41264361)
105 previous assembly GRCz10 (GCF_000002035.5) 17 NC_007128.6 (41126686..41309449)

Chromosome 17 - NC_007128.7Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein L33 Neighboring gene ribokinase Neighboring gene uncharacterized LOC101885155 Neighboring gene FOS like 2, AP-1 transcription factor subunit Neighboring gene molybdenum cofactor synthesis 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Phylogenetic and Expression Analysis of Fos Transcription Factors in Zebrafish. Kubra K, et al. Int J Mol Sci, 2022 Sep 3. PMID 36077499, Free PMC Article
  2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
  5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables polyubiquitin modification-dependent protein binding IEA
Inferred from Electronic Annotation
more info
  
enables polyubiquitin modification-dependent protein binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within DNA repair IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within chromatin organization IEA
Inferred from Electronic Annotation
more info
  
involved_in chromatin organization IEA
Inferred from Electronic Annotation
more info
  
involved_in double-strand break repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in double-strand break repair IEA
Inferred from Electronic Annotation
more info
  
involved_in double-strand break repair ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in mitotic G2 DNA damage checkpoint signaling IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic G2 DNA damage checkpoint signaling ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of DNA repair ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in response to ionizing radiation IEA
Inferred from Electronic Annotation
more info
  
involved_in response to ionizing radiation ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of BRCA1-A complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of BRCA1-A complex IEA
Inferred from Electronic Annotation
more info
  
part_of BRCA1-A complex ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of BRISC complex IEA
Inferred from Electronic Annotation
more info
  
part_of BRISC complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
BRISC and BRCA1-A complex member 2
Names
BRCA1-A complex subunit BRE
BRCA1/BRCA2-containing complex subunit 45
brain and reproductive organ-expressed protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001017777.1 → NP_001017777.1  BRISC and BRCA1-A complex member 2

    See identical proteins and their annotated locations for NP_001017777.1

    Status: PROVISIONAL

    Source sequence(s)
    BC092902
    UniProtKB/Swiss-Prot
    Q568D5
    Related
    ENSDARP00000056741.5, ENSDART00000056742.8
    Conserved Domains (1) summary
    pfam06113
    Location:11 → 336
    BRE; Brain and reproductive organ-expressed protein (BRE)

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007128.7 Reference GRCz11 Primary Assembly

    Range
    41081997..41264361
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021467158.2 → XP_021322833.1  BRISC and BRCA1-A complex member 2 isoform X1

    UniProtKB/TrEMBL
    A0A8M9P8W4
    Conserved Domains (1) summary
    pfam06113
    Location:11 → 336
    BRE; Brain and reproductive organ-expressed protein (BRE)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q568D5.1 GenPept UniProtKB/Swiss-Prot:Q568D5

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