capns1a calpain, small subunit 1 a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: capns1aprovided by ZNC
Official Full Name: calpain, small subunit 1 aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030113-3
See related: Ensembl:ENSDARG00000035329 AllianceGenome:ZFIN:ZDB-GENE-030113-3
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cb616; capns1; wu:fb81g08; wu:fl09e04; zgc:110603
Summary: Predicted to enable calcium ion binding activity. Predicted to be part of calpain complex. Is expressed in several structures, including EVL; digestive system; epidermis; pectoral fin bud; and pronephros. Orthologous to several human genes including CAPNS1 (calpain small subunit 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: chromosome: 5

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	5	NC_007116.7 (36654819..36665691)
105	previous assembly	GRCz10 (GCF_000002035.5)	5	NC_007116.6 (36054666..36065538)

Chromosome 5 - NC_007116.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fb81g08.x1 (e-PCR)
- UniSTS:191652

fb81g08.x1 (e-PCR)
- UniSTS:191653

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of calpain complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: calpain small subunit 1a

NP_001017899.2

EC 3.4.22.17

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001017899.2 → NP_001017899.2 calpain small subunit 1a

Status: VALIDATED

Source sequence(s)

BC092946, CB352301, CV490399

UniProtKB/TrEMBL

A0A8M1N5G8, Q1LYC9

Related

ENSDARP00000119693.1, ENSDART00000131339.3

Conserved Domains (2) summary

cd00051
Location:125 → 175

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cl08302
Location:92 → 142

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...