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atraid all-trans retinoic acid-induced differentiation factor [ Danio rerio (zebrafish) ]

Gene ID: 553468, updated on 4-Jan-2025

Summary

Official Symbol
atraidprovided by ZNC
Official Full Name
all-trans retinoic acid-induced differentiation factorprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040724-177
See related
Ensembl:ENSDARG00000043388 AllianceGenome:ZFIN:ZDB-GENE-040724-177
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
apr3; APR-3; si:ch211-101l18.3
Summary
Predicted to be involved in several processes, including negative regulation of osteoblast proliferation; positive regulation of bone mineralization; and positive regulation of osteoblast differentiation. Predicted to act upstream of or within cell differentiation. Predicted to be located in nuclear envelope and perinuclear region of cytoplasm. Predicted to be active in intracellular membrane-bounded organelle. Orthologous to human ATRAID (all-trans retinoic acid induced differentiation factor). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

See atraid in Genome Data Viewer
Location:
chromosome: 20
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (19512727..19516643)
105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (19613144..19617060)

Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 513a Neighboring gene sorting nexin 17 Neighboring gene eukaryotic translation initiation factor 2B, subunit 4 delta Neighboring gene transfer RNA leucine (anticodon CAG)

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

General gene information

Markers

Gene Ontology Provided by ZFIN

Process Evidence Code Pubs
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of osteoblast proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of bone mineralization ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of osteoblast differentiation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of osteoblast differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in lysosomal membrane IEA
Inferred from Electronic Annotation
more info
 
located_in lysosome IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nuclear envelope ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in perinuclear region of cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
all-trans retinoic acid-induced differentiation factor
Names
apoptosis related protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001044773.1NP_001038238.1  all-trans retinoic acid-induced differentiation factor precursor

    See identical proteins and their annotated locations for NP_001038238.1

    Status: VALIDATED

    Source sequence(s)
    BC133993, BX276101, EH497084
    UniProtKB/Swiss-Prot
    A3KNS9, Q502E7, Q5RID6
    Related
    ENSDARP00000063695.5, ENSDART00000063696.6
    Conserved Domains (2) summary
    sd00031
    Location:96118
    LRR_1; leucine-rich repeat [structural motif]
    pfam13855
    Location:76124
    LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007131.7 Reference GRCz11 Primary Assembly

    Range
    19512727..19516643
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)