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asb6 ankyrin repeat and SOCS box containing 6 [ Danio rerio (zebrafish) ]

Gene ID: 553600, updated on 4-Jan-2025

Summary

Official Symbol
asb6provided by ZNC
Official Full Name
ankyrin repeat and SOCS box containing 6provided by ZNC
Primary source
ZFIN:ZDB-GENE-050522-338
See related
Ensembl:ENSDARG00000007125 AllianceGenome:ZFIN:ZDB-GENE-050522-338
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:110231
Summary
Predicted to be involved in protein ubiquitination. Predicted to act upstream of or within intracellular signal transduction. Orthologous to human ASB6 (ankyrin repeat and SOCS box containing 6). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

See asb6 in Genome Data Viewer
Location:
chromosome: 8
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (6903327..6918721, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (6859779..6875173, complement)

Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene si:ch211-255g12.8 Neighboring gene neurofilament light chain b Neighboring gene WD repeat domain 13 Neighboring gene si:ch211-255g12.6

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

General gene information

Clone Names

  • MGC110231

Gene Ontology Provided by ZFIN

General protein information

Preferred Names
ankyrin repeat and SOCS box protein 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001020576.2NP_001018412.1  ankyrin repeat and SOCS box protein 6

    See identical proteins and their annotated locations for NP_001018412.1

    Status: PROVISIONAL

    Source sequence(s)
    BC095208
    UniProtKB/TrEMBL
    A0A8M2BE50, Q503S0
    Related
    ENSDARP00000018746.6, ENSDART00000014915.8
    Conserved Domains (5) summary
    cd00204
    Location:97207
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd03725
    Location:374417
    SOCS_ASB6; SOCS (suppressors of cytokine signaling) box of ASB6-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB6 interacts with the adaptor protein APS and recruits elongin B/C to the insulin receptor ...
    pfam12796
    Location:100199
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:66116
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:99126
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007119.7 Reference GRCz11 Primary Assembly

    Range
    6903327..6918721 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005166692.5XP_005166749.2  ankyrin repeat and SOCS box protein 6 isoform X1

    UniProtKB/TrEMBL
    A0A8M2BE50, A0A8M2BE57, B0R1B6
  2. XM_021478258.2XP_021333933.1  ankyrin repeat and SOCS box protein 6 isoform X1

    UniProtKB/TrEMBL
    A0A8M2BE50, A0A8M2BE57, B0R1B6
    Conserved Domains (4) summary
    PHA02884
    Location:49138
    PHA02884; ankyrin repeat protein; Provisional
    cd00204
    Location:97207
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd03725
    Location:374417
    SOCS_ASB6; SOCS (suppressors of cytokine signaling) box of ASB6-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB6 interacts with the adaptor protein APS and recruits elongin B/C to the insulin receptor ...
    sd00045
    Location:99126
    ANK; ANK repeat [structural motif]
  3. XM_021478259.2XP_021333934.1  ankyrin repeat and SOCS box protein 6 isoform X1

    UniProtKB/TrEMBL
    A0A8M2BE50, A0A8M2BE57, B0R1B6
    Conserved Domains (4) summary
    PHA02884
    Location:49138
    PHA02884; ankyrin repeat protein; Provisional
    cd00204
    Location:97207
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd03725
    Location:374417
    SOCS_ASB6; SOCS (suppressors of cytokine signaling) box of ASB6-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB6 interacts with the adaptor protein APS and recruits elongin B/C to the insulin receptor ...
    sd00045
    Location:99126
    ANK; ANK repeat [structural motif]
  4. XM_005166695.5XP_005166752.1  ankyrin repeat and SOCS box protein 6 isoform X1

    See identical proteins and their annotated locations for XP_005166752.1

    UniProtKB/TrEMBL
    A0A8M2BE50, A0A8M2BE57, B0R1B6
    Conserved Domains (4) summary
    PHA02884
    Location:49138
    PHA02884; ankyrin repeat protein; Provisional
    cd00204
    Location:97207
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd03725
    Location:374417
    SOCS_ASB6; SOCS (suppressors of cytokine signaling) box of ASB6-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB6 interacts with the adaptor protein APS and recruits elongin B/C to the insulin receptor ...
    sd00045
    Location:99126
    ANK; ANK repeat [structural motif]
  5. XM_005166694.5XP_005166751.1  ankyrin repeat and SOCS box protein 6 isoform X1

    See identical proteins and their annotated locations for XP_005166751.1

    UniProtKB/TrEMBL
    A0A8M2BE50, A0A8M2BE57, B0R1B6
    Conserved Domains (4) summary
    PHA02884
    Location:49138
    PHA02884; ankyrin repeat protein; Provisional
    cd00204
    Location:97207
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd03725
    Location:374417
    SOCS_ASB6; SOCS (suppressors of cytokine signaling) box of ASB6-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB6 interacts with the adaptor protein APS and recruits elongin B/C to the insulin receptor ...
    sd00045
    Location:99126
    ANK; ANK repeat [structural motif]
  6. XM_005166693.5XP_005166750.1  ankyrin repeat and SOCS box protein 6 isoform X1

    See identical proteins and their annotated locations for XP_005166750.1

    UniProtKB/TrEMBL
    A0A8M2BE50, A0A8M2BE57, B0R1B6
    Conserved Domains (4) summary
    PHA02884
    Location:49138
    PHA02884; ankyrin repeat protein; Provisional
    cd00204
    Location:97207
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd03725
    Location:374417
    SOCS_ASB6; SOCS (suppressors of cytokine signaling) box of ASB6-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB6 interacts with the adaptor protein APS and recruits elongin B/C to the insulin receptor ...
    sd00045
    Location:99126
    ANK; ANK repeat [structural motif]
  7. XM_017357334.3XP_017212823.1  ankyrin repeat and SOCS box protein 6 isoform X1

    UniProtKB/TrEMBL
    A0A8M2BE50, A0A8M2BE57, B0R1B6
    Conserved Domains (4) summary
    PHA02884
    Location:49138
    PHA02884; ankyrin repeat protein; Provisional
    cd00204
    Location:97207
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd03725
    Location:374417
    SOCS_ASB6; SOCS (suppressors of cytokine signaling) box of ASB6-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB6 interacts with the adaptor protein APS and recruits elongin B/C to the insulin receptor ...
    sd00045
    Location:99126
    ANK; ANK repeat [structural motif]
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