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pole4 polymerase (DNA-directed), epsilon 4, accessory subunit [ Danio rerio (zebrafish) ]

Gene ID: 553610, updated on 4-Jan-2025

Summary

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Official Symbol
pole4provided by ZNC
Official Full Name
polymerase (DNA-directed), epsilon 4, accessory subunitprovided by ZNC
Primary source
ZFIN:ZDB-GENE-050522-309
See related
Ensembl:ENSDARG00000013016 AllianceGenome:ZFIN:ZDB-GENE-050522-309
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:110337
Summary
Predicted to enable DNA-directed DNA polymerase activity and protein heterodimerization activity. Predicted to be involved in DNA-templated DNA replication. Predicted to be part of epsilon DNA polymerase complex. Predicted to be active in nucleus. Orthologous to human POLE4 (DNA polymerase epsilon 4, accessory subunit). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
human mouse all
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Genomic context

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See pole4 in Genome Data Viewer
Location:
chromosome: 11
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 11 NC_007122.7 (6197275..6206622, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 11 NC_007122.6 (6200022..6209410, complement)

Chromosome 11 - NC_007122.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 1 member 6 Neighboring gene chemokine (C-C motif) ligand 44 Neighboring gene serine/threonine-protein kinase NIM1 Neighboring gene chemokine (C-C motif) ligand 25b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. A network of epigenetic regulators guides developmental haematopoiesis in vivo. Huang HT, et al. Nat Cell Biol, 2013 Dec. PMID 24240475, Free PMC Article
  2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC110337

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA-directed DNA polymerase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA-templated DNA replication IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of epsilon DNA polymerase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
DNA polymerase epsilon subunit 4
NP_001338727.1
XP_017213760.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001351798.1 → NP_001338727.1  DNA polymerase epsilon subunit 4

    Status: VALIDATED

    Source sequence(s)
    EH448501, EH461577
    UniProtKB/TrEMBL
    A0A8M1P5S3
    Related
    ENSDARP00000119014.1, ENSDART00000148246.3
    Conserved Domains (1) summary
    cl28542
    Location:51 → 122
    BUR6; Class 2 transcription repressor NC2, alpha subunit (DRAP1 homolog) [Transcription]

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007122.7 Reference GRCz11 Primary Assembly

    Range
    6197275..6206622 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017358271.3 → XP_017213760.1  DNA polymerase epsilon subunit 4 isoform X1

    UniProtKB/TrEMBL
    A0A8M6Z8Q3, F1RCI6
    Related
    ENSDARP00000016362.7, ENSDART00000019440.9

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001020584.1: Suppressed sequence

    Description
    NM_001020584.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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