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ints11 integrator complex subunit 11 [ Danio rerio (zebrafish) ]

Gene ID: 553648, updated on 4-Jan-2025

Summary

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Official Symbol
ints11provided by ZNC
Official Full Name
integrator complex subunit 11provided by ZNC
Primary source
ZFIN:ZDB-GENE-050522-13
See related
Ensembl:ENSDARG00000025212 AllianceGenome:ZFIN:ZDB-GENE-050522-13
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
cpsf3l; zgc:110671
Summary
Predicted to enable RNA endonuclease activity. Acts upstream of or within regulation of RNA splicing. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with motor and language delay, ocular defects, and brain abnormalities. Orthologous to human INTS11 (integrator complex subunit 11). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
human mouse all
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Genomic context

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See ints11 in Genome Data Viewer
Location:
chromosome: 23
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 23 NC_007134.7 (37062307..37085959, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 23 NC_007134.6 (36959442..36983297, complement)

Chromosome 23 - NC_007134.7Genomic Context describing neighboring genes Neighboring gene ArfGAP with coiled-coil, ankyrin repeat and PH domains 3a Neighboring gene zmp:0000001084 Neighboring gene UBX domain protein 10 Neighboring gene ceramide-1-phosphate transfer protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Biallelic sequence variants in INTS1 in patients with developmental delays, cataracts, and craniofacial anomalies. Krall M, et al. Eur J Hum Genet, 2019 Apr. PMID 30622326, Free PMC Article
  2. The Integrator subunits function in hematopoiesis by modulating Smad/BMP signaling. Tao S, et al. Development, 2009 Aug. PMID 19605500
  3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC110671

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables RNA endonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA endonuclease activity, producing 3'-phosphomonoesters IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within regulation of RNA splicing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in snRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
integrator complex subunit 11
Names
CPSF3-like protein
cleavage and polyadenylation specific factor 3-like
cleavage and polyadenylation-specific factor 3-like protein
int11
NP_001018457.1
XP_005166266.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001020621.1 → NP_001018457.1  integrator complex subunit 11

    See identical proteins and their annotated locations for NP_001018457.1

    Status: PROVISIONAL

    Source sequence(s)
    BC095364
    UniProtKB/Swiss-Prot
    Q503E1
    Related
    ENSDARP00000119202.1, ENSDART00000139662.3
    Conserved Domains (4) summary
    smart01027
    Location:245 → 363
    Beta-Casp; Beta-Casp domain
    COG1236
    Location:4 → 442
    YSH1; RNA processing exonuclease, beta-lactamase fold, Cft2 family [Translation, ribosomal structure and biogenesis]
    pfam07521
    Location:377 → 416
    RMMBL; RNA-metabolizing metallo-beta-lactamase
    cd16291
    Location:6 → 204
    INTS11-like_MBL-fold; Integrator complex subunit 11, and related proteins; MBL-fold metallo-hydrolase domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007134.7 Reference GRCz11 Primary Assembly

    Range
    37062307..37085959 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005166209.5 → XP_005166266.1  integrator complex subunit 11 isoform X1

    UniProtKB/TrEMBL
    A0A8M2BDS7, F1QEY5
    Related
    ENSDARP00000032843.9, ENSDART00000031016.9
    Conserved Domains (4) summary
    smart01027
    Location:245 → 363
    Beta-Casp; Beta-Casp domain
    COG1236
    Location:4 → 442
    YSH1; RNA processing exonuclease, beta-lactamase fold, Cft2 family [Translation, ribosomal structure and biogenesis]
    pfam07521
    Location:377 → 416
    RMMBL; RNA-metabolizing metallo-beta-lactamase
    cd16291
    Location:6 → 204
    INTS11-like_MBL-fold; Integrator complex subunit 11, and related proteins; MBL-fold metallo-hydrolase domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q503E1.1 GenPept UniProtKB/Swiss-Prot:Q503E1

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