U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

H4C15 H4 clustered histone 15 [ Homo sapiens (human) ]

Gene ID: 554313, updated on 27-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
H4C15provided by HGNC
Official Full Name
H4 clustered histone 15provided by HGNC
Primary source
HGNC:HGNC:29607
See related
Ensembl:ENSG00000270276 AllianceGenome:HGNC:29607
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
H4/o; H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4-16; H4C11; H4C12; H4C13; H4C14; H4C16; HIST2H4B
Summary
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-dependent histone that is a member of the histone H4 family. Some transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in a histone cluster on chromosome 1. This gene is one of four histone genes in the cluster that are duplicated; this record represents the telomeric copy. [provided by RefSeq, May 2020]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See H4C15 in Genome Data Viewer
Location:
1q21.2
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (149844488..149861240, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (148978230..148985386, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (149825657..149832725, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:149816892-149817655 Neighboring gene H2A clustered histone 18 Neighboring gene H2B clustered histone 19, pseudogene Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:149822691-149823368 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:149824048-149824725 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:149824726-149825404 Neighboring gene H2B clustered histone 20, pseudogene Neighboring gene H2A clustered histone 19 Neighboring gene H3 clustered histone 15 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1655 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:149856835-149857428 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1657 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1658 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1659 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1660 Neighboring gene H2B clustered histone 21 Neighboring gene H2A clustered histone 20

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Maintenance of open chromatin and selective genomic occupancy at the cell cycle-regulated histone H4 promoter during differentiation of HL-60 promyelocytic leukemia cells. Hovhannisyan H, et al. Mol Cell Biol, 2003 Feb. PMID 12556504, Free PMC Article
  2. Coordinate control and selective expression of the full complement of replication-dependent histone H4 genes in normal and cancer cells. Holmes WF, et al. J Biol Chem, 2005 Nov 11. PMID 16131487
  3. A major human histone gene cluster on the long arm of chromosome 1. Green L, et al. Science, 1984 Nov 16. PMID 6494913
  4. Identification and characterization of two closely related histone H4 arginine 3 methyltransferases in Arabidopsis thaliana. Yan D, et al. Biochem J, 2007 Nov 15. PMID 17666011, Free PMC Article
  5. Proapoptotic function of the retinoblastoma tumor suppressor protein. Ianari A, et al. Cancer Cell, 2009 Mar 3. PMID 19249677, Free PMC Article

See all (131) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

Go to the top of the page Help

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA binding TAS
Traceable Author Statement
more info
 PubMed 
enables RNA binding HDA PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
  
enables structural constituent of chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in chromatin organization NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in negative regulation of megakaryocyte differentiation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in nucleosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nucleosome assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein localization to CENP-A containing chromatin NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in telomere organization TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of CENP-A containing nucleosome IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in chromosome, telomeric region HDA PubMed 
located_in extracellular exosome HDA PubMed 
located_in extracellular region TAS
Traceable Author Statement
more info
  
located_in membrane HDA PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
part_of nucleosome IDA
Inferred from Direct Assay
more info
 PubMed 
part_of nucleosome IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of nucleosome TAS
Traceable Author Statement
more info
 PubMed 
located_in nucleus HDA PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
histone H4
Names
histone 2, H4b
histone cluster 2 H4 family member b
histone cluster 2, H4b

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001034077.4 → NP_001029249.1  histone H4

    See identical proteins and their annotated locations for NP_001029249.1

    Status: REVIEWED

    Source sequence(s)
    AC239868
    Consensus CDS
    CCDS30851.1
    UniProtKB/Swiss-Prot
    A2VCL0, P02304, P02305, P62805, Q6DRA9, Q6FGB8, Q6NWP7
    UniProtKB/TrEMBL
    B2R4R0
    Related
    ENSP00000462355.1, ENST00000579512.3
    Conserved Domains (1) summary
    PLN00035
    Location:1 → 103
    PLN00035; histone H4; Provisional

RNA

  1. NR_168446.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC239868

  2. NR_168447.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC239868

  3. NR_168448.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC239868

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    149844488..149861240 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047424442.1 → XP_047280398.1  histone H4 isoform X1

    UniProtKB/Swiss-Prot
    A2VCL0, P02304, P02305, P62805, Q6DRA9, Q6FGB8, Q6NWP7
    UniProtKB/TrEMBL
    B2R4R0

  2. XM_047424439.1 → XP_047280395.1  histone H4 isoform X1

    UniProtKB/Swiss-Prot
    A2VCL0, P02304, P02305, P62805, Q6DRA9, Q6FGB8, Q6NWP7
    UniProtKB/TrEMBL
    B2R4R0

  3. XM_024451708.2 → XP_024307476.2  histone H4 isoform X1

    UniProtKB/Swiss-Prot
    A2VCL0, P02304, P02305, P62805, Q6DRA9, Q6FGB8, Q6NWP7
    UniProtKB/TrEMBL
    B2R4R0

  4. XM_047424434.1 → XP_047280390.1  histone H4 isoform X1

    UniProtKB/Swiss-Prot
    A2VCL0, P02304, P02305, P62805, Q6DRA9, Q6FGB8, Q6NWP7
    UniProtKB/TrEMBL
    B2R4R0

  5. XM_047424436.1 → XP_047280392.1  histone H4 isoform X1

    UniProtKB/Swiss-Prot
    A2VCL0, P02304, P02305, P62805, Q6DRA9, Q6FGB8, Q6NWP7
    UniProtKB/TrEMBL
    B2R4R0
    Related
    ENSP00000482412.1, ENST00000612061.1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    148978230..148985386 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054337526.1 → XP_054193501.1  histone H4 isoform X1

    UniProtKB/Swiss-Prot
    A2VCL0, P02304, P02305, P62805, Q6DRA9, Q6FGB8, Q6NWP7
    UniProtKB/TrEMBL
    B2R4R0
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P62805.2 GenPept UniProtKB/Swiss-Prot:P62805

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Miscellaneous