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cpdb carboxypeptidase D, b [ Danio rerio (zebrafish) ]

Gene ID: 555848, updated on 4-Jan-2025

Summary

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Official Symbol
cpdbprovided by ZNC
Official Full Name
carboxypeptidase D, bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-060929-1270
See related
Ensembl:ENSDARG00000053877 AllianceGenome:ZFIN:ZDB-GENE-060929-1270
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:152928
Summary
Predicted to enable metallocarboxypeptidase activity. Predicted to be involved in peptide metabolic process and protein processing. Predicted to act upstream of or within proteolysis. Predicted to be located in membrane. Predicted to be active in extracellular space. Orthologous to human CPD (carboxypeptidase D). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See cpdb in Genome Data Viewer
Location:
chromosome: 21
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (39197418..39226333)
105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (39152360..39181275)

Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene unc-119 lipid binding chaperone a2 Neighboring gene crystallin, beta A1b Neighboring gene trafficking regulator of GLUT4 (SLC2A4) 1b (gene/pseudogene) Neighboring gene si:ch211-274p24.2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Analysis of the mast cell expressed carboxypeptidase A3 and its structural and evolutionary relationship to other vertebrate carboxypeptidases. Akula S, et al. Dev Comp Immunol, 2022 Feb. PMID 34619175
  2. Genetic Control of Collective Behavior in Zebrafish. Tang W, et al. iScience, 2020 Mar 27. PMID 32179471, Free PMC Article
  3. Evolution of the tbx6/16 subfamily genes in vertebrates: insights from zebrafish. Ahn D, et al. Mol Biol Evol, 2012 Dec. PMID 22915831
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC152928

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables carboxypeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metallocarboxypeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metallocarboxypeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in peptide metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein processing IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
carboxypeptidase D, b
NP_001315329.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001328400.1 → NP_001315329.1  carboxypeptidase D, b

    Status: VALIDATED

    Source sequence(s)
    BX005137
    UniProtKB/TrEMBL
    A0A8M1PA92, E7FFQ7
    Related
    ENSDARP00000070479.5, ENSDART00000076000.6
    Conserved Domains (2) summary
    cd11308
    Location:314 → 389
    Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain
    cl11393
    Location:35 → 310
    Peptidase_M14_like; M14 family of metallocarboxypeptidases and related proteins

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007132.7 Reference GRCz11 Primary Assembly

    Range
    39197418..39226333
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001077540.1: Suppressed sequence

    Description
    NM_001077540.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein
Heading Accession and Version

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