primpol primase and polymerase (DNA-directed) [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: primpolprovided by ZNC
Official Full Name: primase and polymerase (DNA-directed)provided by ZNC
Primary source: ZFIN:ZDB-GENE-051113-100
See related: Ensembl:ENSDARG00000033273 AllianceGenome:ZFIN:ZDB-GENE-051113-100
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: ccdc111; zgc:123274
Summary: Predicted to enable chromatin binding activity; nucleotidyltransferase activity; and transition metal ion binding activity. Predicted to be involved in DNA metabolic process; R-loop processing; and response to UV. Predicted to act upstream of or within DNA repair. Predicted to be located in replication fork. Predicted to be part of DNA-directed RNA polymerase complex. Predicted to be active in mitochondrial matrix and nucleus. Human ortholog(s) of this gene implicated in myopia. Orthologous to human PRIMPOL (primase and DNA directed polymerase). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 1

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	1	NC_007112.7 (21563334..21573009)
105	previous assembly	GRCz10 (GCF_000002035.5)	1	NC_007112.6 (20870400..20880072)

Chromosome 1 - NC_007112.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fi67g03.y1 (e-PCR)
- UniSTS:197840

G39322 (e-PCR)
- UniSTS:27357

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA primase activity	IBA Inferred from Biological aspect of Ancestor more info
enables DNA primase activity	IEA Inferred from Electronic Annotation more info
enables DNA primase activity	ISS Inferred from Sequence or Structural Similarity more info
enables DNA-directed DNA polymerase activity	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-directed DNA polymerase activity	IEA Inferred from Electronic Annotation more info
enables DNA-directed DNA polymerase activity	ISS Inferred from Sequence or Structural Similarity more info
enables chromatin binding	IBA Inferred from Biological aspect of Ancestor more info
enables chromatin binding	ISS Inferred from Sequence or Structural Similarity more info
enables manganese ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleotidyltransferase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA damage response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within DNA repair	IEA Inferred from Electronic Annotation more info
involved_in R-loop processing	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within error-prone translesion synthesis	IEA Inferred from Electronic Annotation more info
involved_in error-prone translesion synthesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitochondrial DNA repair	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitochondrial DNA replication	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial DNA replication	ISS Inferred from Sequence or Structural Similarity more info
involved_in replication fork processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in replication fork processing	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to UV	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to UV	ISS Inferred from Sequence or Structural Similarity more info
involved_in translesion synthesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in translesion synthesis	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of DNA-directed RNA polymerase complex	IEA Inferred from Electronic Annotation more info
located_in chromosome	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrial matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial matrix	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in replication fork	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: DNA-directed primase/polymerase protein

Names: coiled-coil domain containing 111; coiled-coil domain-containing protein 111 homolog

NP_001032455.2

EC 2.7.7.102

EC 2.7.7.7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.