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PLGRKT plasminogen receptor with a C-terminal lysine [ Homo sapiens (human) ]

Gene ID: 55848, updated on 27-Nov-2024

Summary

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Official Symbol
PLGRKTprovided by HGNC
Official Full Name
plasminogen receptor with a C-terminal lysineprovided by HGNC
Primary source
HGNC:HGNC:23633
See related
Ensembl:ENSG00000107020 MIM:618444; AllianceGenome:HGNC:23633
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AD025; MDS030; C9orf46; PLG-RKT; Plg-R(KT)
Summary
Predicted to be involved in positive regulation of plasminogen activation. Located in mitochondrion. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in colon (RPKM 12.9), duodenum (RPKM 11.8) and 24 other tissues See more
Orthologs
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Genomic context

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See PLGRKT in Genome Data Viewer
Location:
9p24.1
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (5357971..5438377, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (5363085..5447429, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (5357971..5437925, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr9:5327251-5327751 Neighboring gene high mobility group nucleosomal binding domain 2 pseudogene 31 Neighboring gene relaxin 2 Neighboring gene relaxin 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:5418516-5418928 Neighboring gene ring finger protein 152 pseudogene 1 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr9:5437227-5438426 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28159 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28160 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28161 Neighboring gene uncharacterized LOC124902114 Neighboring gene Sharpr-MPRA regulatory region 9164 Neighboring gene OCT4 hESC enhancer GRCh37_chr9:5482138-5482639 Neighboring gene CD274 molecule Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28163 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28164 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28165 Neighboring gene Sharpr-MPRA regulatory region 6415 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:5501887-5502388 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr9:5509079-5510278 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28167 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28168 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28169 Neighboring gene programmed cell death 1 ligand 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28170 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19753 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28171

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Plg-R(KT) Expression in Human Breast Cancer Tissues. Miles LA, et al. Biomolecules, 2022 Mar 26. PMID 35454092, Free PMC Article
  2. The plasminogen receptor Plg-R(KT) regulates adipose function and metabolic homeostasis. Samad F, et al. J Thromb Haemost, 2022 Mar. PMID 34897983, Free PMC Article
  3. Exposure of plasminogen and a novel plasminogen receptor, Plg-RKT, on activated human and murine platelets. Whyte CS, et al. Blood, 2021 Jan 14. PMID 32842150, Free PMC Article
  4. The novel plasminogen receptor, plasminogen receptor(KT) (Plg-R(KT)), regulates catecholamine release. Bai H, et al. J Biol Chem, 2011 Sep 23. PMID 21795689, Free PMC Article
  5. Regulation of macrophage migration by a novel plasminogen receptor Plg-R KT. Lighvani S, et al. Blood, 2011 Nov 17. PMID 21940822, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Plg-RKT Expression in Human Breast Cancer Tissues.
    Title: Plg-R(KT) Expression in Human Breast Cancer Tissues.
  2. The plasminogen receptor Plg-RKT regulates adipose function and metabolic homeostasis.
    Title: The plasminogen receptor Plg-R(KT) regulates adipose function and metabolic homeostasis.
  3. Exposure of plasminogen and a novel plasminogen receptor, Plg-RKT, on activated human and murine platelets.
    Title: Exposure of plasminogen and a novel plasminogen receptor, Plg-RKT, on activated human and murine platelets.
  4. Plasminogen and the Plasminogen Receptor, Plg-RKT, Regulate Macrophage Phenotypic, and Functional Changes.
    Title: Plasminogen and the Plasminogen Receptor, Plg-R(KT), Regulate Macrophage Phenotypic, and Functional Changes.
  5. Plg-R(KT) was highly expressed in bovine adrenomedullary chromaffin cells, human pheochromocytoma tissue, PC12 pheochromocytoma cells, and murine hippocampus.
    Title: The novel plasminogen receptor, plasminogen receptor(KT) (Plg-R(KT)), regulates catecholamine release.
  6. Plg-R(KT) plays a key role in the plasminogen-dependent regulation of macrophage invasion, chemotactic migration, and recruitment in the inflammatory response.
    Title: Regulation of macrophage migration by a novel plasminogen receptor Plg-R KT.
  7. Observational study of gene-disease association. (HuGE Navigator)
    Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
  8. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ14688, FLJ39176

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in chemotaxis IEA
Inferred from Electronic Annotation
more info
  
involved_in inflammatory response IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of plasminogen activation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in mitochondrion HTP PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
plasminogen receptor (KT)
Names
5033414D02Rik
plasminogen receptor, C-terminal lysine transmembrane protein
transmembrane protein C9orf46

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018465.4 → NP_060935.2  plasminogen receptor (KT)

    See identical proteins and their annotated locations for NP_060935.2

    Status: VALIDATED

    Source sequence(s)
    AA919015, AK027594, BM693747
    Consensus CDS
    CCDS6463.1
    UniProtKB/Swiss-Prot
    B2R6W0, Q9HBL7, Q9NZ44
    Related
    ENSP00000223864.2, ENST00000223864.7
    Conserved Domains (1) summary
    pfam10166
    Location:1 → 134
    DUF2368; Uncharacterized conserved protein (DUF2368)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    5357971..5438377 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005251510.6 → XP_005251567.1  plasminogen receptor (KT) isoform X1

    See identical proteins and their annotated locations for XP_005251567.1

    UniProtKB/Swiss-Prot
    B2R6W0, Q9HBL7, Q9NZ44
    Conserved Domains (1) summary
    pfam10166
    Location:1 → 134
    DUF2368; Uncharacterized conserved protein (DUF2368)

  2. XM_011517960.3 → XP_011516262.1  plasminogen receptor (KT) isoform X1

    See identical proteins and their annotated locations for XP_011516262.1

    UniProtKB/Swiss-Prot
    B2R6W0, Q9HBL7, Q9NZ44
    Conserved Domains (1) summary
    pfam10166
    Location:1 → 134
    DUF2368; Uncharacterized conserved protein (DUF2368)

  3. XM_005251512.5 → XP_005251569.1  plasminogen receptor (KT) isoform X2

    Conserved Domains (1) summary
    pfam10166
    Location:1 → 101
    DUF2368; uncharacterized conserved protein (DUF2368)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    5363085..5447429 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054363281.1 → XP_054219256.1  plasminogen receptor (KT) isoform X1

    UniProtKB/Swiss-Prot
    B2R6W0, Q9HBL7, Q9NZ44

  2. XM_054363282.1 → XP_054219257.1  plasminogen receptor (KT) isoform X1

    UniProtKB/Swiss-Prot
    B2R6W0, Q9HBL7, Q9NZ44

  3. XM_054363283.1 → XP_054219258.1  plasminogen receptor (KT) isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9HBL7.1 GenPept UniProtKB/Swiss-Prot:Q9HBL7

Gene LinkOut

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