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cnksr2b connector enhancer of kinase suppressor of Ras 2b [ Danio rerio (zebrafish) ]

Gene ID: 558834, updated on 4-Jan-2025

Summary

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Official Symbol
cnksr2bprovided by ZNC
Official Full Name
connector enhancer of kinase suppressor of Ras 2bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-8048
See related
Ensembl:ENSDARG00000073707 AllianceGenome:ZFIN:ZDB-GENE-030131-8048
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fj48e09; wu:fj48e09; si:dkey-92k1.12
Summary
Predicted to enable kinase activity. Predicted to act upstream of or within phosphorylation and regulation of signal transduction. Predicted to be located in cytoplasm and membrane. Human ortholog(s) of this gene implicated in syndromic X-linked mental retardation Hough type. Orthologous to human CNKSR2 (connector enhancer of kinase suppressor of Ras 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See cnksr2b in Genome Data Viewer
Location:
chromosome: 21
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (25425161..25522993, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (25388556..25486433, complement)

Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene protein phosphatase methylesterase 1 Neighboring gene spermine synthase Neighboring gene si:dkey-17e16.9 Neighboring gene NLR family, CARD domain containing 3-like 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Multi-omics reveal mechanisms underlying chronic kidney disease of unknown etiology (CKDu) pathogenesis using zebrafish. Wei XY, et al. Environ Pollut, 2023 Nov 15. PMID 37683759
  2. Expression pattern of the small muscle protein, X-linked (smpx) gene during zebrafish embryonic and larval developmental stages. Ghilardi A, et al. Gene Expr Patterns, 2020 Jun. PMID 32197943
  3. Phenotypic Landscape of Schizophrenia-Associated Genes Defines Candidates and Their Shared Functions. Thyme SB, et al. Cell, 2019 Apr 4. PMID 30929901, Free PMC Article
  4. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
connector enhancer of kinase suppressor of ras 2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007132.7 Reference GRCz11 Primary Assembly

    Range
    25425161..25522993 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_682101.8 → XP_687193.3  connector enhancer of kinase suppressor of ras 2 isoform X2

    UniProtKB/TrEMBL
    A0A8N7UV27, E7FAZ0
    Related
    ENSDARP00000103132.3, ENSDART00000110923.4
    Conserved Domains (7) summary
    cd09511
    Location:8 → 76
    SAM_CNK1,2,3-suppressor; SAM domain of CNK1,2,3-suppressor subfamily
    smart00454
    Location:8 → 73
    SAM; Sterile alpha motif
    cd00992
    Location:223 → 294
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd01260
    Location:549 → 661
    PH_CNK_mammalian-like; Connector enhancer of KSR (Kinase suppressor of ras) (CNK) pleckstrin homology (PH) domain
    pfam00169
    Location:563 → 659
    PH; PH domain
    pfam06663
    Location:341 → 469
    DUF1170; Protein of unknown function (DUF1170)
    pfam10534
    Location:84 → 176
    CRIC_ras_sig; Connector enhancer of kinase suppressor of ras

  2. XM_009295430.4 → XP_009293705.1  connector enhancer of kinase suppressor of ras 2 isoform X1

    UniProtKB/TrEMBL
    A0A8M3AM98
    Conserved Domains (7) summary
    cd09511
    Location:8 → 76
    SAM_CNK1,2,3-suppressor; SAM domain of CNK1,2,3-suppressor subfamily
    smart00454
    Location:8 → 73
    SAM; Sterile alpha motif
    cd00992
    Location:229 → 300
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd01260
    Location:555 → 667
    PH_CNK_mammalian-like; Connector enhancer of KSR (Kinase suppressor of ras) (CNK) pleckstrin homology (PH) domain
    pfam00169
    Location:569 → 665
    PH; PH domain
    pfam06663
    Location:347 → 475
    DUF1170; Protein of unknown function (DUF1170)
    pfam10534
    Location:84 → 182
    CRIC_ras_sig; Connector enhancer of kinase suppressor of ras
Nucleotide Protein Strain
Heading Accession and Version

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