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clk2a CDC-like kinase 2a [ Danio rerio (zebrafish) ]

Gene ID: 558981, updated on 4-Jan-2025

Summary

Official Symbol
clk2aprovided by ZNC
Official Full Name
CDC-like kinase 2aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-298
See related
Ensembl:ENSDARG00000062954 AllianceGenome:ZFIN:ZDB-GENE-030131-298
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
clk2; fb20c02; wu:fb20c02; si:ch211-81a5.7
Summary
Predicted to enable protein serine/threonine kinase activity and protein tyrosine kinase activity. Predicted to be involved in regulation of RNA splicing. Predicted to act upstream of or within protein phosphorylation. Predicted to be active in nucleus. Orthologous to human CLK2 (CDC like kinase 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

See clk2a in Genome Data Viewer
Location:
chromosome: 19
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 19 NC_007130.7 (9150037..9169225)
105 previous assembly GRCz10 (GCF_000002035.5) 19 NC_007130.6 (9231101..9250300)

Chromosome 19 - NC_007130.7Genomic Context describing neighboring genes Neighboring gene leucine rich repeat containing 71 Neighboring gene SET domain bifurcated histone lysine methyltransferase 1a Neighboring gene si:ch211-81a5.8 Neighboring gene hyperpolarization activated cyclic nucleotide-gated potassium channel 3

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein serine/threonine/tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of RNA splicing IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
dual specificity protein kinase CLK2
Names
CDC-like kinase 2
NP_001038344.1
XP_005159494.1
XP_009292322.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001044879.2NP_001038344.1  dual specificity protein kinase CLK2

    See identical proteins and their annotated locations for NP_001038344.1

    Status: VALIDATED

    Source sequence(s)
    BC171572, EH435802, EH447847, EH461802
    UniProtKB/TrEMBL
    B7ZVF9, Q1L8U4
    Related
    ENSDARP00000112318.2, ENSDART00000127803.4
    Conserved Domains (4) summary
    smart00220
    Location:187503
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14215
    Location:174503
    PKc_CLK2; Catalytic domain of the Dual-specificity protein kinase, CDC-like kinase 2
    pfam08648
    Location:34117
    DUF1777; Protein of unknown function (DUF1777)
    pfam12871
    Location:37104
    PRP38_assoc; Pre-mRNA-splicing factor 38-associated hydrophilic C-term

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007130.7 Reference GRCz11 Primary Assembly

    Range
    9150037..9169225
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009294047.4XP_009292322.1  dual specificity protein kinase CLK2 isoform X1

    See identical proteins and their annotated locations for XP_009292322.1

    UniProtKB/TrEMBL
    B7ZVF9, Q1L8U4
    Conserved Domains (4) summary
    smart00220
    Location:187503
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14215
    Location:174503
    PKc_CLK2; Catalytic domain of the Dual-specificity protein kinase, CDC-like kinase 2
    pfam08648
    Location:34117
    DUF1777; Protein of unknown function (DUF1777)
    pfam12871
    Location:37104
    PRP38_assoc; Pre-mRNA-splicing factor 38-associated hydrophilic C-term
  2. XM_005159437.5XP_005159494.1  dual specificity protein kinase CLK2 isoform X2

    UniProtKB/TrEMBL
    A0A8M2B5Z1
    Conserved Domains (2) summary
    smart00220
    Location:6302
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:1302
    PKc_like; Protein Kinases, catalytic domain