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acaca acetyl-CoA carboxylase alpha [ Danio rerio (zebrafish) ]

Gene ID: 559403, updated on 19-Jan-2025

Summary

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Official Symbol
acacaprovided by ZNC
Official Full Name
acetyl-CoA carboxylase alphaprovided by ZNC
Primary source
ZFIN:ZDB-GENE-060526-74
See related
Ensembl:ENSDARG00000078512 AllianceGenome:ZFIN:ZDB-GENE-060526-74
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
acc; fj43d01; im:7138837; wu:fj43d01; si:ch211-199d18.1
Summary
Predicted to enable ATP binding activity; acetyl-CoA carboxylase activity; and metal ion binding activity. Acts upstream of or within response to (R)-carnitine. Predicted to be located in cytoplasm. Is expressed in female organism; liver; male organism; subcutaneous fat; and visceral fat. Orthologous to human ACACA (acetyl-CoA carboxylase alpha). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
human mouse all
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Genomic context

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See acaca in Genome Data Viewer
Location:
chromosome: 5
Exon count:
56
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (56308616..56416176, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (55638405..55746037, complement)

Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene LIM homeobox 1b Neighboring gene apoptosis antagonizing transcription factor Neighboring gene T-box transcription factor 2a Neighboring gene uncharacterized LOC137490762

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Effects of dietary biotin and avidin on growth, survival, feed conversion, biotin status and gene expression of zebrafish Danio rerio. Yossa R, et al. Comp Biochem Physiol B Biochem Mol Biol, 2011 Dec. PMID 21839851
  2. Polyunsaturated fatty acyl-coenzyme As are inhibitors of cholesterol biosynthesis in zebrafish and mice. Karanth S, et al. Dis Model Mech, 2013 Nov. PMID 24057001, Free PMC Article
  3. Androgen signaling inhibits de novo lipogenesis to alleviate lipid deposition in zebrafish. Jia JY, et al. Zool Res, 2024 Mar 18. PMID 38485505, Free PMC Article
  4. Transcriptional activity and developmental expression of liver X receptor (lxr) in zebrafish. Archer A, et al. Dev Dyn, 2008 Apr. PMID 18297735
  5. A novel transgenic zebrafish line allows for in vivo quantification of autophagic activity in neurons. Khuansuwan S, et al. Autophagy, 2019 Aug. PMID 30755067, Free PMC Article

See all (111) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables acetyl-CoA carboxylase activity IEA
Inferred from Electronic Annotation
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within fatty acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in malonyl-CoA biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within response to (R)-carnitine IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
acetyl-CoA carboxylase 1
Names
acetyl-Coenzyme A carboxylase alpha
NP_001258237.1
XP_017211598.1
XP_017211600.1
XP_017211601.1
XP_017211602.1
XP_017211603.1
XP_017211604.1
XP_017211606.1
XP_021331867.1
XP_021331868.1
XP_021331869.1
XP_021331870.1
XP_021331871.1
XP_021331872.1
XP_021331873.1
XP_021331874.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271308.1 → NP_001258237.1  acetyl-CoA carboxylase 1

    Status: PROVISIONAL

    Source sequence(s)
    AL935115, BX255908
    UniProtKB/TrEMBL
    A0A8M1NZ82, A0A8M9QE20, F1QH12
    Related
    ENSDARP00000077514.5, ENSDART00000083079.6
    Conserved Domains (7) summary
    COG0439
    Location:118 → 621
    AccC; Biotin carboxylase [Lipid transport and metabolism]
    pfam00289
    Location:118 → 237
    CPSase_L_chain; Carbamoyl-phosphate synthase L chain, N-terminal domain
    pfam00364
    Location:753 → 818
    Biotin_lipoyl; Biotin-requiring enzyme
    pfam01039
    Location:1712 → 2266
    Carboxyl_trans; Carboxyl transferase domain
    pfam02785
    Location:507 → 614
    Biotin_carb_C; Biotin carboxylase C-terminal domain
    pfam08326
    Location:820 → 1612
    ACC_central; Acetyl-CoA carboxylase, central region
    cl17255
    Location:279 → 470
    ATP-grasp_4; ATP-grasp domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007116.7 Reference GRCz11 Primary Assembly

    Range
    56308616..56416176 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021476199.2 → XP_021331874.1  acetyl-CoA carboxylase 1 isoform X12

    UniProtKB/TrEMBL
    A0A8M9Q3F9, A0A8M9QE20
    Conserved Domains (4) summary
    COG0439
    Location:118 → 621
    AccC; Biotin carboxylase [Lipid transport and metabolism]
    pfam00364
    Location:753 → 818
    Biotin_lipoyl; Biotin-requiring enzyme
    pfam01039
    Location:1670 → 2224
    Carboxyl_trans; Carboxyl transferase domain
    pfam08326
    Location:820 → 1563
    ACC_central; Acetyl-CoA carboxylase, central region

  2. XM_021476197.2 → XP_021331872.1  acetyl-CoA carboxylase 1 isoform X7

    UniProtKB/TrEMBL
    A0A8M9PK85, A0A8M9QE20
    Conserved Domains (4) summary
    COG0439
    Location:118 → 621
    AccC; Biotin carboxylase [Lipid transport and metabolism]
    pfam00364
    Location:753 → 818
    Biotin_lipoyl; Biotin-requiring enzyme
    pfam01039
    Location:1705 → 2259
    Carboxyl_trans; Carboxyl transferase domain
    pfam08326
    Location:820 → 1598
    ACC_central; Acetyl-CoA carboxylase, central region

  3. XM_017356115.3 → XP_017211604.1  acetyl-CoA carboxylase 1 isoform X13

    UniProtKB/TrEMBL
    A0A8M6Z6C9, A0A8M9QE20

  4. XM_021476198.2 → XP_021331873.1  acetyl-CoA carboxylase 1 isoform X8

    UniProtKB/TrEMBL
    A0A8M9PXQ3, A0A8M9QE20
    Conserved Domains (4) summary
    COG0439
    Location:118 → 621
    AccC; Biotin carboxylase [Lipid transport and metabolism]
    pfam00364
    Location:753 → 818
    Biotin_lipoyl; Biotin-requiring enzyme
    pfam01039
    Location:1698 → 2252
    Carboxyl_trans; Carboxyl transferase domain
    pfam08326
    Location:820 → 1591
    ACC_central; Acetyl-CoA carboxylase, central region

  5. XM_017356117.3 → XP_017211606.1  acetyl-CoA carboxylase 1 isoform X14

    UniProtKB/TrEMBL
    A0A8M6YZ52, A0A8M9QE20

  6. XM_017356114.3 → XP_017211603.1  acetyl-CoA carboxylase 1 isoform X11

    UniProtKB/TrEMBL
    A0A8M6YY91, A0A8M9QE20

  7. XM_021476196.2 → XP_021331871.1  acetyl-CoA carboxylase 1 isoform X4

    UniProtKB/TrEMBL
    A0A8M9Q8Q1, A0A8M9QE20
    Conserved Domains (4) summary
    COG0439
    Location:118 → 621
    AccC; Biotin carboxylase [Lipid transport and metabolism]
    pfam00364
    Location:753 → 818
    Biotin_lipoyl; Biotin-requiring enzyme
    pfam01039
    Location:1713 → 2267
    Carboxyl_trans; Carboxyl transferase domain
    pfam08326
    Location:820 → 1606
    ACC_central; Acetyl-CoA carboxylase, central region

  8. XM_017356113.3 → XP_017211602.1  acetyl-CoA carboxylase 1 isoform X10

    UniProtKB/TrEMBL
    A0A8M6Z6X1, A0A8M9QE20

  9. XM_017356112.3 → XP_017211601.1  acetyl-CoA carboxylase 1 isoform X9

    UniProtKB/TrEMBL
    A0A2R8QJA0, A0A8M6Z0L9, A0A8M9QE20

  10. XM_021476195.2 → XP_021331870.1  acetyl-CoA carboxylase 1 isoform X3

    UniProtKB/TrEMBL
    A0A8M9QE14, A0A8M9QE20
    Conserved Domains (4) summary
    COG0439
    Location:118 → 621
    AccC; Biotin carboxylase [Lipid transport and metabolism]
    pfam00364
    Location:753 → 818
    Biotin_lipoyl; Biotin-requiring enzyme
    pfam01039
    Location:1732 → 2286
    Carboxyl_trans; Carboxyl transferase domain
    pfam08326
    Location:820 → 1625
    ACC_central; Acetyl-CoA carboxylase, central region

  11. XM_017356111.3 → XP_017211600.1  acetyl-CoA carboxylase 1 isoform X6

    UniProtKB/TrEMBL
    A0A8M6YZ47, A0A8M9QE20, F6P055
    Related
    ENSDARP00000122142.2, ENSDART00000146773.4

  12. XM_017356109.3 → XP_017211598.1  acetyl-CoA carboxylase 1 isoform X5

    UniProtKB/TrEMBL
    A0A8M1NZ82, A0A8M9QE20, F1QH12
    Conserved Domains (7) summary
    COG0439
    Location:118 → 621
    AccC; Biotin carboxylase [Lipid transport and metabolism]
    pfam00289
    Location:118 → 237
    CPSase_L_chain; Carbamoyl-phosphate synthase L chain, N-terminal domain
    pfam00364
    Location:753 → 818
    Biotin_lipoyl; Biotin-requiring enzyme
    pfam01039
    Location:1712 → 2266
    Carboxyl_trans; Carboxyl transferase domain
    pfam02785
    Location:507 → 614
    Biotin_carb_C; Biotin carboxylase C-terminal domain
    pfam08326
    Location:820 → 1612
    ACC_central; Acetyl-CoA carboxylase, central region
    cl17255
    Location:279 → 470
    ATP-grasp_4; ATP-grasp domain

  13. XM_021476194.2 → XP_021331869.1  acetyl-CoA carboxylase 1 isoform X2

    UniProtKB/TrEMBL
    A0A8M9Q3F2, A0A8M9QE20
    Conserved Domains (4) summary
    COG0439
    Location:118 → 621
    AccC; Biotin carboxylase [Lipid transport and metabolism]
    pfam00364
    Location:753 → 818
    Biotin_lipoyl; Biotin-requiring enzyme
    pfam01039
    Location:1740 → 2294
    Carboxyl_trans; Carboxyl transferase domain
    pfam08326
    Location:820 → 1633
    ACC_central; Acetyl-CoA carboxylase, central region

  14. XM_021476192.2 → XP_021331867.1  acetyl-CoA carboxylase 1 isoform X1

    UniProtKB/TrEMBL
    A0A8M9PK80, A0A8M9QE20
    Conserved Domains (4) summary
    COG0439
    Location:118 → 621
    AccC; Biotin carboxylase [Lipid transport and metabolism]
    pfam00364
    Location:753 → 818
    Biotin_lipoyl; Biotin-requiring enzyme
    pfam01039
    Location:1747 → 2301
    Carboxyl_trans; Carboxyl transferase domain
    pfam08326
    Location:820 → 1640
    ACC_central; Acetyl-CoA carboxylase, central region

  15. XM_021476193.2 → XP_021331868.1  acetyl-CoA carboxylase 1 isoform X1

    UniProtKB/TrEMBL
    A0A8M9PK80, A0A8M9QE20
    Conserved Domains (4) summary
    COG0439
    Location:118 → 621
    AccC; Biotin carboxylase [Lipid transport and metabolism]
    pfam00364
    Location:753 → 818
    Biotin_lipoyl; Biotin-requiring enzyme
    pfam01039
    Location:1747 → 2301
    Carboxyl_trans; Carboxyl transferase domain
    pfam08326
    Location:820 → 1640
    ACC_central; Acetyl-CoA carboxylase, central region

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394614.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    50377..161998 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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