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usp49 ubiquitin specific peptidase 49 [ Danio rerio (zebrafish) ]

Gene ID: 559473, updated on 4-Jan-2025

Summary

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Official Symbol
usp49provided by ZNC
Official Full Name
ubiquitin specific peptidase 49provided by ZNC
Primary source
ZFIN:ZDB-GENE-050208-484
See related
Ensembl:ENSDARG00000000229 AllianceGenome:ZFIN:ZDB-GENE-050208-484
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
si:rp71-11b17.7
Summary
Predicted to enable cysteine-type deubiquitinase activity and zinc ion binding activity. Predicted to act upstream of or within protein deubiquitination and proteolysis. Predicted to be active in cytoplasm. Orthologous to human USP49 (ubiquitin specific peptidase 49). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
human mouse all
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Genomic context

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See usp49 in Genome Data Viewer
Location:
chromosome: 22
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 22 NC_007133.7 (565818..582831)
105 previous assembly GRCz10 (GCF_000002035.5) 22 NC_007133.6 (526915..544158)

Chromosome 22 - NC_007133.7Genomic Context describing neighboring genes Neighboring gene bystin-like Neighboring gene mediator complex subunit 20 Neighboring gene transmembrane and coiled-coil domain family 2 Neighboring gene cyclin dependent kinase inhibitor 1A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Genome-wide loss-of-function analysis of deubiquitylating enzymes for zebrafish development. Tse WK, et al. BMC Genomics, 2009 Dec 30. PMID 20040115, Free PMC Article
  2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables cysteine-type deubiquitinase activity IEA
Inferred from Electronic Annotation
more info
  
enables cysteine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within protein deubiquitination IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ubiquitin carboxyl-terminal hydrolase 49
NP_001038361.1
XP_005168329.1
XP_009294033.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001044896.1 → NP_001038361.1  ubiquitin carboxyl-terminal hydrolase 49

    See identical proteins and their annotated locations for NP_001038361.1

    Status: PROVISIONAL

    Source sequence(s)
    AL645789
    UniProtKB/TrEMBL
    A0A0R4IEA5, Q1MTK1
    Related
    ENSDARP00000036071.4, ENSDART00000037069.5
    Conserved Domains (3) summary
    cl02553
    Location:266 → 645
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam00443
    Location:264 → 644
    UCH; Ubiquitin carboxyl-terminal hydrolase
    pfam02148
    Location:26 → 87
    zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007133.7 Reference GRCz11 Primary Assembly

    Range
    565818..582831
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005168272.5 → XP_005168329.1  ubiquitin carboxyl-terminal hydrolase 49 isoform X1

    See identical proteins and their annotated locations for XP_005168329.1

    UniProtKB/TrEMBL
    A0A0R4IEA5, Q1MTK1
    Conserved Domains (3) summary
    cl02553
    Location:266 → 645
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam00443
    Location:264 → 644
    UCH; Ubiquitin carboxyl-terminal hydrolase
    pfam02148
    Location:26 → 87
    zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein

  2. XM_009295758.4 → XP_009294033.1  ubiquitin carboxyl-terminal hydrolase 49 isoform X1

    See identical proteins and their annotated locations for XP_009294033.1

    UniProtKB/TrEMBL
    A0A0R4IEA5, Q1MTK1
    Related
    ENSDARP00000133726.1, ENSDART00000171036.2
    Conserved Domains (3) summary
    cl02553
    Location:266 → 645
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam00443
    Location:264 → 644
    UCH; Ubiquitin carboxyl-terminal hydrolase
    pfam02148
    Location:26 → 87
    zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
Nucleotide Protein Strain
Heading Accession and Version

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