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Akr1e1 aldo-keto reductase family 1, member E1 [ Mus musculus (house mouse) ]

Gene ID: 56043, updated on 27-Nov-2024

Summary

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Official Symbol
Akr1e1provided by MGI
Official Full Name
aldo-keto reductase family 1, member E1provided by MGI
Primary source
MGI:MGI:1914758
See related
Ensembl:ENSMUSG00000045410 AllianceGenome:MGI:1914758
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Akr1e2; 1810061I10Rik
Summary
Predicted to enable aldose reductase (NADPH) activity. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Is expressed in central nervous system; embryo; and retina. Orthologous to human AKR1E2 (aldo-keto reductase family 1 member E2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in bladder adult (RPKM 12.4), CNS E11.5 (RPKM 11.5) and 22 other tissues See more
Orthologs
human all
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Genomic context

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See Akr1e1 in Genome Data Viewer
Location:
13 A1; 13 2.57 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (4641122..4659163, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (4591123..4609164, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_33513 Neighboring gene STARR-seq mESC enhancer starr_33514 Neighboring gene predicted gene, 40657 Neighboring gene aldo-keto reductase family 1, member C21 Neighboring gene ribosomal protein L29, pseudogene 2 Neighboring gene STARR-seq mESC enhancer starr_33515 Neighboring gene STARR-seq mESC enhancer starr_33516 Neighboring gene predicted gene, 40658

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Characterization of a novel murine aldo-keto reductase. Bohren KM, et al. Adv Exp Med Biol, 1997. PMID 9059651
  2. Mouse AKR1E1 is an ortholog of pig liver NADPH dependent 1,5-anhydro-D-fructose reductase. Sakuma M, et al. Biosci Biotechnol Biochem, 2008 Mar. PMID 18323634
  3. A cluster of eight hydroxysteroid dehydrogenase genes belonging to the aldo-keto reductase supergene family on mouse chromosome 13. Vergnes L, et al. J Lipid Res, 2003 Mar. PMID 12562828
  4. Genomic analysis of mouse retinal development. Blackshaw S, et al. PLoS Biol, 2004 Sep. PMID 15226823, Free PMC Article
  5. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 1,5-anhydro-D-fructose reductase activity IEA
Inferred from Electronic Annotation
more info
  
enables aldose reductase (NADPH) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables oxidoreductase activity ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
1,5-anhydro-D-fructose reductase
Names
AF reductase
aldo-keto reductase family 1 member C-like protein 2
aldo-keto reductase family 1 member E2
NP_061347.2
XP_006516548.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018859.2 → NP_061347.2  1,5-anhydro-D-fructose reductase

    See identical proteins and their annotated locations for NP_061347.2

    Status: VALIDATED

    Source sequence(s)
    AI893997, AK002507, BQ174229
    Consensus CDS
    CCDS26226.1
    UniProtKB/Swiss-Prot
    O09125, Q9DCT1
    UniProtKB/TrEMBL
    Q8CEB6
    Related
    ENSMUSP00000089459.6, ENSMUST00000091848.7
    Conserved Domains (2) summary
    COG0656
    Location:4 → 282
    ARA1; Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism]
    COG0667
    Location:4 → 287
    Tas; Predicted oxidoreductase (related to aryl-alcohol dehydrogenase) [General function prediction only]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    4641122..4659163 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006516485.3 → XP_006516548.1  1,5-anhydro-D-fructose reductase isoform X1

    Conserved Domains (1) summary
    cl00470
    Location:17 → 210
    AKR_SF; Aldo-keto reductase (AKR) superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9DCT1.1 GenPept UniProtKB/Swiss-Prot:Q9DCT1

Gene LinkOut

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