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Msln mesothelin [ Mus musculus (house mouse) ]

Gene ID: 56047, updated on 27-Nov-2024

Summary

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Official Symbol
Mslnprovided by MGI
Official Full Name
mesothelinprovided by MGI
Primary source
MGI:MGI:1888992
See related
Ensembl:ENSMUSG00000063011 AllianceGenome:MGI:1888992
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MPF
Summary
Predicted to be involved in cell-matrix adhesion. Located in extracellular space. Is expressed in several structures, including body cavity or lining; genitourinary system; gut; heart; and respiratory system. Human ortholog(s) of this gene implicated in ovarian cancer; pancreas disease; pancreatic cancer; and pancreatic ductal carcinoma. Orthologous to human MSLN (mesothelin). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in lung adult (RPKM 25.5), ovary adult (RPKM 11.4) and 13 other tissues See more
Orthologs
human all
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Genomic context

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See Msln in Genome Data Viewer
Location:
17 A3.3; 17 12.85 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (25967587..25973352, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (25748613..25754378, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene CTF18, chromosome transmission fidelity factor 18 Neighboring gene STARR-positive B cell enhancer ABC_E3190 Neighboring gene RNA pseudouridylate synthase domain containing 1 Neighboring gene mesothelin-like Neighboring gene STARR-seq mESC enhancer starr_42110 Neighboring gene predicted gene, 41550 Neighboring gene STARR-positive B cell enhancer ABC_E3191 Neighboring gene cytosolic iron-sulfur assembly component 3 Neighboring gene microRNA 6966 Neighboring gene hydroxyacylglutathione hydrolase-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Macrophages Under the Influence of Tumor Mesothelin Weaken Host Defenses against Pancreatic Cancer Metastasis. Alewine C. Cancer Res, 2024 Feb 15. PMID 38356442
  2. Megakaryocytic potentiating factor and mature mesothelin stimulate the growth of a lung cancer cell line in the peritoneal cavity of mice. Zhang J, et al. PLoS One, 2014. PMID 25118887, Free PMC Article
  3. Murine mesothelin: characterization, expression, and inhibition of tumor growth in a murine model of pancreatic cancer. Zervos E, et al. J Exp Clin Cancer Res, 2016 Mar 1. PMID 26931187, Free PMC Article
  4. Mesothelin is not required for normal mouse development or reproduction. Bera TK, et al. Mol Cell Biol, 2000 Apr. PMID 10733593, Free PMC Article
  5. Overexpression of sulfatase-1 in murine hepatocarcinoma Hca-F cell line downregulates mesothelin and leads to reduction in lymphatic metastasis, both in vitro and in vivo. Mahmoud S, et al. Oncotarget, 2016 Nov 15. PMID 27626699, Free PMC Article

See all (46) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Macrophages Under the Influence of Tumor Mesothelin Weaken Host Defenses against Pancreatic Cancer Metastasis.
    Title: Macrophages Under the Influence of Tumor Mesothelin Weaken Host Defenses against Pancreatic Cancer Metastasis.
  2. Novel mesothelin-targeted chimeric antigen receptor-modified UNKT cells are highly effective in inhibiting tumor progression.
    Title: Novel mesothelin-targeted chimeric antigen receptor-modified UNKT cells are highly effective in inhibiting tumor progression.
  3. Host Mesothelin Expression Increases Ovarian Cancer Metastasis in the Peritoneal Microenvironment.
    Title: Host Mesothelin Expression Increases Ovarian Cancer Metastasis in the Peritoneal Microenvironment.
  4. Immunotherapy-based targeting of MSLN(+) activated portal fibroblasts is a strategy for treatment of cholestatic liver fibrosis.
    Title: Immunotherapy-based targeting of MSLN(+) activated portal fibroblasts is a strategy for treatment of cholestatic liver fibrosis.
  5. our findings show that Sulf-1 is an important tumor suppressor gene in hepatocellular carcinoma (HCC), and its over expression downregulates Msln and results in a decrease in HCC cell proliferation, migration, invasion, and lymphatic metastasis.
    Title: Overexpression of sulfatase-1 in murine hepatocarcinoma Hca-F cell line downregulates mesothelin and leads to reduction in lymphatic metastasis, both in vitro and in vivo.
  6. Mesothelin/mucin 16 signaling in activated portal fibroblasts regulates cholestatic liver fibrosis.(
    Title: Mesothelin/mucin 16 signaling in activated portal fibroblasts regulates cholestatic liver fibrosis.
  7. Results show that mouse mesothelin is similar to human mesothelin. Its stable overexpression in a pancreatic cancer cell line did not increase cell proliferation, suggesting that mesothelin is not necessarily a tumor progression factor.
    Title: Murine mesothelin: characterization, expression, and inhibition of tumor growth in a murine model of pancreatic cancer.
  8. MSLN has an important role in the growth of lung cancer cells in vivo raising the possibility that inactivation of MPF may be a useful treatment for lung and other MSLN expressing cancers.
    Title: Megakaryocytic potentiating factor and mature mesothelin stimulate the growth of a lung cancer cell line in the peritoneal cavity of mice.
  9. The mesothelin expression promotes resistance to certain chemotherapy drugs such as TNF-alpha, paclitaxel, and a combination of platinum and cyclophosphamide.
    Title: The role of mesothelin in tumor progression and targeted therapy.
  10. Mesothelin overexpression promotes mesothelioma cell invasion and MMP-9 secretion.
    Title: Mesothelin overexpression promotes mesothelioma cell invasion and MMP-9 secretion in an orthotopic mouse model and in epithelioid pleural mesothelioma patients.
Submit: New GeneRIF Correction See all GeneRIFs (12)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in cell-matrix adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular space HDA PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in side of membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
mesothelin
Names
megakaryocyte potentiating factor
pre-pro-megakaryocyte-potentiating factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001356286.1 → NP_001343215.1  mesothelin isoform 1 preproprotein

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK144391, D86370
    Consensus CDS
    CCDS28526.1
    UniProtKB/Swiss-Prot
    Q61468
    Related
    ENSMUSP00000158474.2, ENSMUST00000237359.2
    Conserved Domains (1) summary
    pfam06060
    Location:1 → 624
    Mesothelin; Pre-pro-megakaryocyte potentiating factor precursor (Mesothelin)

  2. NM_001374653.1 → NP_001361582.1  mesothelin isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC134908
    UniProtKB/TrEMBL
    A0A494B9A6
    Related
    ENSMUSP00000157558.2, ENSMUST00000236137.2
    Conserved Domains (1) summary
    pfam06060
    Location:1 → 628
    Mesothelin; Pre-pro-megakaryocyte potentiating factor precursor (Mesothelin)

  3. NM_018857.2 → NP_061345.1  mesothelin isoform 1 preproprotein

    See identical proteins and their annotated locations for NP_061345.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) retains an intron in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK144391, AK146799, D86370
    Consensus CDS
    CCDS28526.1
    UniProtKB/Swiss-Prot
    Q61468
    Related
    ENSMUSP00000158357.2, ENSMUST00000238120.2
    Conserved Domains (1) summary
    pfam06060
    Location:1 → 624
    Mesothelin; Pre-pro-megakaryocyte potentiating factor precursor (Mesothelin)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    25967587..25973352 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q61468.1 GenPept UniProtKB/Swiss-Prot:Q61468

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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