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htra2-8 HtrA serine peptidase 2-8 [ Danio rerio (zebrafish) ]

Gene ID: 560704, updated on 4-Jan-2025

Summary

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Official Symbol
htra2-8provided by ZNC
Official Full Name
HtrA serine peptidase 2-8provided by ZNC
Primary source
ZFIN:ZDB-GENE-081028-29
See related
AllianceGenome:ZFIN:ZDB-GENE-081028-29
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
si:dkey-33c12.11
Summary
Human ortholog(s) of this gene implicated in 3-methylglutaconic aciduria type 8; Parkinson's disease; and motor neuron disease. Orthologous to human HTRA2 (HtrA serine peptidase 2). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See htra2-8 in Genome Data Viewer
Location:
chromosome: 13
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (9188072..9210001, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (8856371..8862606, complement)

Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene HtrA serine peptidase 2-7 Neighboring gene Pim proto-oncogene, serine/threonine kinase, related 156 Neighboring gene si:dkey-33c12.12 Neighboring gene Pim proto-oncogene, serine/threonine kinase, related 158

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General protein information

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Preferred Names
serine protease HTRA2, mitochondrial
Names
novel serine protease protein

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007124.7 Reference GRCz11 Primary Assembly

    Range
    9188072..9210001 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068213136.1 → XP_068069237.1  serine protease HTRA2, mitochondrial

    UniProtKB/TrEMBL
    A0A8M9QAR7

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394865.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    352079..374010 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068218710.1 → XP_068074811.1  serine protease HTRA2, mitochondrial

    UniProtKB/TrEMBL
    A0A8M9QAR7
Nucleotide Protein
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Research Materials