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ide insulin-degrading enzyme [ Danio rerio (zebrafish) ]

Gene ID: 561390, updated on 12-Jan-2025

Summary

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Official Symbol
ideprovided by ZNC
Official Full Name
insulin-degrading enzymeprovided by ZNC
Primary source
ZFIN:ZDB-GENE-070410-85
See related
Ensembl:ENSDARG00000075570 AllianceGenome:ZFIN:ZDB-GENE-070410-85
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:162603
Summary
Predicted to enable metalloendopeptidase activity. Acts upstream of or within pancreas regeneration and type B pancreatic cell development. Predicted to be active in cytosol; mitochondrion; and peroxisomal matrix. Is expressed in myotome. Human ortholog(s) of this gene implicated in Alzheimer's disease and type 2 diabetes mellitus. Orthologous to human IDE (insulin degrading enzyme). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
human mouse all
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Genomic context

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See ide in Genome Data Viewer
Location:
chromosome: 13
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (42309580..42353427)
105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (42183506..42226316)

Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene kynurenine 3-monooxygenase Neighboring gene transfer RNA histidin (anticodon GUG) Neighboring gene membrane-associated ring finger (C3HC4) 5 Neighboring gene cytoplasmic polyadenylation element binding protein 3 Neighboring gene BTAF1 RNA polymerase II, B-TFIID transcription factor-associated

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Thifluzamide affects lipid metabolism in zebrafish (Danio reio). Yang Y, et al. Sci Total Environ, 2018 Aug 15. PMID 29758875
  2. Altered glycometabolism in zebrafish exposed to thifluzamide. Yang Y, et al. Chemosphere, 2017 Sep. PMID 28535465
  3. Toxic effects of boscalid in adult zebrafish (Danio rerio) on carbohydrate and lipid metabolism. Qian L, et al. Environ Pollut, 2019 Apr. PMID 30721868
  4. Insertional mutagenesis by the Tol2 transposon-mediated enhancer trap approach generated mutations in two developmental genes: tcf7 and synembryn-like. Nagayoshi S, et al. Development, 2008 Jan. PMID 18065431
  5. Chronic perfluorooctanesulfonic acid exposure disrupts lipid metabolism in zebrafish. Cui Y, et al. Hum Exp Toxicol, 2017 Mar. PMID 27193966

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC162603

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in amyloid-beta metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within endocrine pancreas development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in hormone catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within pancreas regeneration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in peptide catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis involved in protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within type B pancreatic cell development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in peroxisomal matrix IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
insulin-degrading enzyme
Names
insulysin
NP_001082994.2
XP_005169585.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001089525.2 → NP_001082994.2  insulin-degrading enzyme

    Status: VALIDATED

    Source sequence(s)
    BX005050
    UniProtKB/TrEMBL
    A0A0R4IL71, A4QP10, B8JI45
    Related
    ENSDARP00000135107.1, ENSDART00000158367.2

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007124.7 Reference GRCz11 Primary Assembly

    Range
    42309580..42353427
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005169528.5 → XP_005169585.1  insulin-degrading enzyme isoform X1

    UniProtKB/TrEMBL
    A0A8M2BGX2, A4QP10
    Conserved Domains (4) summary
    COG1025
    Location:24 → 939
    Ptr; Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones]
    pfam00675
    Location:53 → 191
    Peptidase_M16; Insulinase (Peptidase family M16)
    pfam05193
    Location:217 → 395
    Peptidase_M16_C; Peptidase M16 inactive domain
    pfam16187
    Location:401 → 682
    Peptidase_M16_M; Middle or third domain of peptidase_M16
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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