U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

slc4a4b solute carrier family 4 member 4b [ Danio rerio (zebrafish) ]

Gene ID: 561618, updated on 4-Jan-2025

Summary

Go to the top of the page Help
Official Symbol
slc4a4bprovided by ZNC
Official Full Name
solute carrier family 4 member 4bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-091030-1
See related
Ensembl:ENSDARG00000044808 AllianceGenome:ZFIN:ZDB-GENE-091030-1
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
nbc1; nbce1
Summary
Predicted to enable monoatomic anion transmembrane transporter activity and solute:inorganic anion antiporter activity. Predicted to act upstream of or within monoatomic anion transport. Predicted to be located in lateral plasma membrane. Is expressed in several structures, including NCC ionocyte; ball; gill; nervous system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in renal tubular acidosis. Orthologous to human SLC4A4 (solute carrier family 4 member 4). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See slc4a4b in Genome Data Viewer
Location:
chromosome: 21
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (5993187..6107536)
105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (5887482..6002028)

Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene MOB kinase activator 1Bb Neighboring gene deoxycytidine kinase Neighboring gene folylpolyglutamate synthase Neighboring gene cyclin-dependent kinase 9 (CDC2-related kinase)

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. A novel function of calcitonin gene-related peptide in body fluid Cl- homeostasis. Wang YF, et al. Proc Biol Sci, 2016 Jun 15. PMID 27306053, Free PMC Article
  2. Anion exchanger 1b, but not sodium-bicarbonate cotransporter 1b, plays a role in transport functions of zebrafish H+-ATPase-rich cells. Lee YC, et al. Am J Physiol Cell Physiol, 2011 Feb. PMID 21123736
  3. Gene expression of Na+/H+ exchanger in zebrafish H+ -ATPase-rich cells during acclimation to low-Na+ and acidic environments. Yan JJ, et al. Am J Physiol Cell Physiol, 2007 Dec. PMID 17913841
  4. Arginine Vasopressin Modulates Ion and Acid/Base Balance by Regulating Cell Numbers of Sodium Chloride Cotransporter and H(+)-ATPase Rich Ionocytes. Tong SK, et al. Int J Mol Sci, 2020 May 31. PMID 32486459, Free PMC Article
  5. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables monoatomic anion transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables solute:inorganic anion antiporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within monoatomic anion transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in lateral plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
electrogenic sodium bicarbonate cotransporter 1
Names
sodium bicarbonate cotransporter
solute carrier family 4 (sodium bicarbonate cotransporter), member 4b
solute carrier family 4, member 4
solute carrier family 4, sodium bicarbonate cotransporter, member 4b

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007132.7 Reference GRCz11 Primary Assembly

    Range
    5993187..6107536
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009295136.4 → XP_009293411.1  electrogenic sodium bicarbonate cotransporter 1 isoform X2

    UniProtKB/TrEMBL
    A0A8M3B4G9, A0A8M9Q313
    Conserved Domains (3) summary
    TIGR00834
    Location:112 → 1033
    ae; anion exchange protein
    pfam00955
    Location:472 → 986
    HCO3_cotransp; HCO3- transporter family
    pfam07565
    Location:140 → 422
    Band_3_cyto; Band 3 cytoplasmic domain

  2. XM_009295135.4 → XP_009293410.1  electrogenic sodium bicarbonate cotransporter 1 isoform X1

    UniProtKB/TrEMBL
    A0A8M3AL80
    Conserved Domains (3) summary
    TIGR00834
    Location:112 → 1033
    ae; anion exchange protein
    pfam00955
    Location:472 → 986
    HCO3_cotransp; HCO3- transporter family
    pfam07565
    Location:140 → 422
    Band_3_cyto; Band 3 cytoplasmic domain

  3. XM_685028.10 → XP_690120.7  electrogenic sodium bicarbonate cotransporter 1 isoform X4

    UniProtKB/TrEMBL
    A0A8M9Q313, A0A8N7UV75
    Related
    ENSDARP00000138946.2, ENSDART00000169613.3
    Conserved Domains (3) summary
    TIGR00834
    Location:112 → 1001
    ae; anion exchange protein
    pfam00955
    Location:440 → 954
    HCO3_cotransp; HCO3- transporter family
    pfam07565
    Location:140 → 390
    Band_3_cyto; Band 3 cytoplasmic domain

  4. XM_005160996.5 → XP_005161053.2  electrogenic sodium bicarbonate cotransporter 1 isoform X3

    UniProtKB/TrEMBL
    A0A8M2B7X0, F1QD14
    Related
    ENSDARP00000048398.7, ENSDART00000048399.8
    Conserved Domains (3) summary
    TIGR00834
    Location:112 → 1001
    ae; anion exchange protein
    pfam00955
    Location:440 → 954
    HCO3_cotransp; HCO3- transporter family
    pfam07565
    Location:140 → 390
    Band_3_cyto; Band 3 cytoplasmic domain

  5. XM_068215971.1 → XP_068072072.1  electrogenic sodium bicarbonate cotransporter 1 isoform X5

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018395078.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    1211..55117
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068218953.1 → XP_068075054.1  electrogenic sodium bicarbonate cotransporter 1 isoform X6

    UniProtKB/TrEMBL
    A0A8M9Q313
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools