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Nagk N-acetylglucosamine kinase [ Mus musculus (house mouse) ]

Gene ID: 56174, updated on 27-Nov-2024

Summary

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Official Symbol
Nagkprovided by MGI
Official Full Name
N-acetylglucosamine kinaseprovided by MGI
Primary source
MGI:MGI:1860418
See related
Ensembl:ENSMUSG00000034744 AllianceGenome:MGI:1860418
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gnk
Summary
Enables N-acetylglucosamine kinase activity; N-acylmannosamine kinase activity; and muramyl dipeptide kinase activity. Involved in positive regulation of nucleotide-binding activity oligomerization domain containing 2 signaling pathway. Acts upstream of or within N-acetylglucosamine metabolic process. Is expressed in several structures, including eye; genitourinary system; liver; nervous system; and spleen. Orthologous to human NAGK (N-acetylglucosamine kinase). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in testis adult (RPKM 14.3), placenta adult (RPKM 11.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Nagk in Genome Data Viewer
Location:
6 C3; 6 35.96 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (83770810..83779538)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (83794983..83802556)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 52907 Neighboring gene predicted gene, 53176 Neighboring gene 60S ribosomal protein L27 pseudogene Neighboring gene poly(A) binding protein interacting protein 2B Neighboring gene STARR-positive B cell enhancer mm9_chr6:83781714-83782015 Neighboring gene predicted gene, 23014

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Upregulation of dendritic arborization by N-acetyl-D-glucosamine kinase is not dependent on its kinase activity. Lee H, et al. Mol Cells, 2014 Apr. PMID 24722415, Free PMC Article
  2. N-acetyl-D-glucosamine kinase binds dynein light chain roadblock 1 and promotes protein aggregate clearance. Ripon MKH, et al. Cell Death Dis, 2020 Aug 14. PMID 32796833, Free PMC Article
  3. Phosphorylation of muramyl peptides by NAGK is required for NOD2 activation. Stafford CA, et al. Nature, 2022 Sep. PMID 36002575, Free PMC Article
  4. Molecular cloning and characterization of murine and human N-acetylglucosamine kinase. Hinderlich S, et al. Eur J Biochem, 2000 Jun. PMID 10824116
  5. Loss of Fam60a, a Sin3a subunit, results in embryonic lethality and is associated with aberrant methylation at a subset of gene promoters. Nabeshima R, et al. Elife, 2018 Aug 2. PMID 30070635, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Phosphorylation of muramyl peptides by NAGK is required for NOD2 activation.
    Title: Phosphorylation of muramyl peptides by NAGK is required for NOD2 activation.
  2. N-acetyl-D-glucosamine kinase binds dynein light chain roadblock 1 and promotes protein aggregate clearance.
    Title: N-acetyl-D-glucosamine kinase binds dynein light chain roadblock 1 and promotes protein aggregate clearance.
  3. small domain, and not kinase activity, promotes dendritogenesis
    Title: Upregulation of dendritic arborization by N-acetyl-D-glucosamine kinase is not dependent on its kinase activity.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Gene trapped (1) 
  • Targeted (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables N-acetylglucosamine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables N-acetylglucosamine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables N-acetylglucosamine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables N-acylmannosamine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables muramyl dipeptide kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables muramyl dipeptide kinase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within N-acetylglucosamine metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in N-acetylneuraminate catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in N-acetylneuraminate catabolic process TAS
Traceable Author Statement
more info
 PubMed 
involved_in carbohydrate phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in defense response to bacterium ISO
Inferred from Sequence Orthology
more info
  
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in response to muramyl dipeptide ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
N-acetyl-D-glucosamine kinase
Names
GlcNAc kinase
N-acetyl-D-mannosamine kinase
muramyl dipeptide kinase
NP_001157659.1
NP_001334244.2
NP_001398209.1
NP_001398210.1
NP_001398211.1
NP_001398212.1
NP_001398213.1
NP_001398214.1
NP_001398215.1
NP_001398216.1
NP_001398217.1
NP_001398218.1
NP_001398219.1
NP_001398220.1
NP_062415.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164187.2 → NP_001157659.1  N-acetyl-D-glucosamine kinase isoform 2

    See identical proteins and their annotated locations for NP_001157659.1

    Status: VALIDATED

    Source sequence(s)
    AC090647, AC156283
    UniProtKB/TrEMBL
    Q9D997
    Related
    ENSMUST00000146117.8
    Conserved Domains (1) summary
    cl17037
    Location:2 → 228
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

  2. NM_001347315.2 → NP_001334244.2  N-acetyl-D-glucosamine kinase isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC090647, AC156283
    Consensus CDS
    CCDS85072.1
    Related
    ENSMUSP00000109482.2, ENSMUST00000113851.8

  3. NM_001411280.1 → NP_001398209.1  N-acetyl-D-glucosamine kinase isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC090647, AC156283

  4. NM_001411281.1 → NP_001398210.1  N-acetyl-D-glucosamine kinase isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC090647, AC156283

  5. NM_001411282.1 → NP_001398211.1  N-acetyl-D-glucosamine kinase isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC090647, AC156283

  6. NM_001411283.1 → NP_001398212.1  N-acetyl-D-glucosamine kinase isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC090647, AC156283

  7. NM_001411284.1 → NP_001398213.1  N-acetyl-D-glucosamine kinase isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC090647, AC156283

  8. NM_001411285.1 → NP_001398214.1  N-acetyl-D-glucosamine kinase isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC090647, AC156283

  9. NM_001411286.1 → NP_001398215.1  N-acetyl-D-glucosamine kinase isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC090647, AC156283

  10. NM_001411287.1 → NP_001398216.1  N-acetyl-D-glucosamine kinase isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC090647, AC156283

  11. NM_001411288.1 → NP_001398217.1  N-acetyl-D-glucosamine kinase isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC090647, AC156283

  12. NM_001411289.1 → NP_001398218.1  N-acetyl-D-glucosamine kinase isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC090647, AC156283

  13. NM_001411290.1 → NP_001398219.1  N-acetyl-D-glucosamine kinase isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC090647, AC156283

  14. NM_001411291.1 → NP_001398220.1  N-acetyl-D-glucosamine kinase isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC090647, AC156283

  15. NM_019542.3 → NP_062415.1  N-acetyl-D-glucosamine kinase isoform 1

    See identical proteins and their annotated locations for NP_062415.1

    Status: VALIDATED

    Source sequence(s)
    AC090647, AC156283
    Consensus CDS
    CCDS20286.1
    UniProtKB/Swiss-Prot
    Q9QZ08
    UniProtKB/TrEMBL
    Q3U2G9, Q9D997
    Related
    ENSMUSP00000042026.8, ENSMUST00000037376.14
    Conserved Domains (1) summary
    cl17037
    Location:1 → 279
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

RNA

  1. NR_177202.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC090647, AC156283

  2. NR_177203.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC090647, AC156283

  3. NR_177204.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC090647, AC156283

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    83770810..83779538
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_004933610.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9QZ08.3 GenPept UniProtKB/Swiss-Prot:Q9QZ08

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