fdx1b ferredoxin 1b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: fdx1bprovided by ZNC
Official Full Name: ferredoxin 1bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-060526-382
See related: Ensembl:ENSDARG00000038956 AllianceGenome:ZFIN:ZDB-GENE-060526-382
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: si:rp71-5c20.1
Summary: Predicted to enable electron transfer activity. Acts upstream of or within cortisol biosynthetic process. Predicted to be active in mitochondrion. Is expressed in brain and endocrine system. Orthologous to human FDX1 (ferredoxin 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: chromosome: 5

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	5	NC_007116.7 (22177033..22226645)
105	previous assembly	GRCz10 (GCF_000002035.5)	5	NC_007116.6 (21673233..21722845)

Chromosome 5 - NC_007116.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

This study establishes an androgen- and cortisol-deficient fdx1b zebrafish mutant as a model for understanding the effects of steroid deficiency on sex development and reproductive function.
Title: Ferredoxin 1b Deficiency Leads to Testis Disorganization, Impaired Spermatogenesis, and Feminization in Zebrafish.
Fdx1b is required for de novo cortisol biosynthesis.
Title: Ferredoxin 1b (Fdx1b) Is the Essential Mitochondrial Redox Partner for Cortisol Biosynthesis in Zebrafish.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables 2 iron, 2 sulfur cluster binding	IEA Inferred from Electronic Annotation more info
enables electron transfer activity	IBA Inferred from Biological aspect of Ancestor more info
enables iron-sulfur cluster binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within P450-containing electron transport chain	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cortisol biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in electron transport chain	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within steroid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: ferredoxin 1b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001100949.1 → NP_001094419.1 ferredoxin 1b

Status: PROVISIONAL

Source sequence(s)

BX465863

UniProtKB/TrEMBL

A0A8M1NFG5, A2BGD1

Related

ENSDARP00000115368.1, ENSDART00000131223.2

Conserved Domains (1) summary

cl00159
Location:51 → 157

fer2; 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis ...