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itpkca inositol-trisphosphate 3-kinase Ca [ Danio rerio (zebrafish) ]

Gene ID: 562919, updated on 4-Jan-2025

Summary

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Official Symbol
itpkcaprovided by ZNC
Official Full Name
inositol-trisphosphate 3-kinase Caprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-6009
See related
Ensembl:ENSDARG00000002994 AllianceGenome:ZFIN:ZDB-GENE-030131-6009
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
itpkc; fi30c01; wu:fi30c01
Summary
Predicted to enable inositol hexakisphosphate kinase activity. Predicted to be involved in inositol phosphate biosynthetic process and phosphatidylinositol phosphate biosynthetic process. Predicted to act upstream of or within phosphorylation. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in colorectal cancer. Orthologous to human ITPKC (inositol-trisphosphate 3-kinase C). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See itpkca in Genome Data Viewer
Location:
chromosome: 21
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (21279155..21298995)
105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (21242009..21262359)

Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene LIF receptor subunit alpha b Neighboring gene coiled-coil domain containing 61 Neighboring gene uncharacterized LOC101882370 Neighboring gene meiosis initiator

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Transforming growth factor-β1 regulates the nascent hematopoietic stem cell niche by promoting gluconeogenesis. Zhang CY, et al. Leukemia, 2018 Feb. PMID 28642593
  2. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article
  3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
  5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables inositol hexakisphosphate kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity, transferring phosphorus-containing groups IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in inositol phosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within inositol phosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphatidylinositol phosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
inositol-trisphosphate 3-kinase C
Names
inositol 1,4,5-trisphosphate 3-kinase C
inositol 1,4,5-trisphosphate 3-kinase Ca
XP_686458.2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007132.7 Reference GRCz11 Primary Assembly

    Range
    21279155..21298995
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_681366.10 → XP_686458.2  inositol-trisphosphate 3-kinase C

    UniProtKB/TrEMBL
    A0A8N7T5H5, E7F4R8, E9QEW6
    Related
    ENSDARP00000119462.2, ENSDART00000148346.3
    Conserved Domains (1) summary
    pfam03770
    Location:200 → 411
    IPK; Inositol polyphosphate kinase
Nucleotide Protein Strain
Heading Accession and Version

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