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gramd1c GRAM domain containing 1c [ Danio rerio (zebrafish) ]

Gene ID: 563054, updated on 4-Jan-2025

Summary

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Official Symbol
gramd1cprovided by ZNC
Official Full Name
GRAM domain containing 1cprovided by ZNC
Primary source
ZFIN:ZDB-GENE-050506-88
See related
Ensembl:ENSDARG00000076238 AllianceGenome:ZFIN:ZDB-GENE-050506-88
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fe11c03; im:6904950; wu:fe11c03; si:ch73-93k15.2
Summary
Predicted to enable cholesterol binding activity and cholesterol transfer activity. Predicted to be involved in intracellular sterol transport. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum membrane; endoplasmic reticulum-plasma membrane contact site; and plasma membrane. Orthologous to human GRAMD1C (GRAM domain containing 1C). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
human mouse all
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Genomic context

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See gramd1c in Genome Data Viewer
Location:
chromosome: 24
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 24 NC_007135.7 (21132978..21150040, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 24 NC_007135.6 (20988662..21005604, complement)

Chromosome 24 - NC_007135.7Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 191 Neighboring gene zinc finger DHHC-type palmitoyltransferase 23b Neighboring gene uncharacterized LOC137489236 Neighboring gene ATPase H+ transporting V1 subunit Ab Neighboring gene N-alpha-acetyltransferase 50, NatE catalytic subunit

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
  3. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables cholesterol binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cholesterol transfer activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in intracellular sterol transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in endoplasmic reticulum-plasma membrane contact site IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
GRAM domain-containing protein 1C; protein Aster-C

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007135.7 Reference GRCz11 Primary Assembly

    Range
    21132978..21150040 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005162729.5 → XP_005162786.1  protein Aster-C

    See identical proteins and their annotated locations for XP_005162786.1

    UniProtKB/TrEMBL
    A0A8M2B9S9, E7F236
    Related
    ENSDARP00000129043.1, ENSDART00000154249.2
    Conserved Domains (2) summary
    cd13220
    Location:97 → 187
    PH-GRAM_GRAMDC; GRAM domain-containing protein (GRAMDC) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
    pfam16016
    Location:357 → 503
    DUF4782; Domain of unknown function (DUF4782)

  2. XM_683292.10 → XP_688384.5  protein Aster-C

    See identical proteins and their annotated locations for XP_688384.5

    UniProtKB/TrEMBL
    A0A8M2B9S9, E7F236
    Related
    ENSDARP00000146528.1, ENSDART00000193256.1
    Conserved Domains (2) summary
    cd13220
    Location:97 → 187
    PH-GRAM_GRAMDC; GRAM domain-containing protein (GRAMDC) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
    pfam16016
    Location:357 → 503
    DUF4782; Domain of unknown function (DUF4782)

RNA

  1. XR_002456628.2 RNA Sequence

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018395170.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    149089..166572 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021473760.2 → XP_021329435.1  protein Aster-C

    UniProtKB/TrEMBL
    A0A8M9Q853
    Conserved Domains (2) summary
    cd13220
    Location:95 → 187
    PH-GRAM_GRAMDC; GRAM domain-containing protein (GRAMDC) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
    pfam16016
    Location:357 → 505
    DUF4782; Domain of unknown function (DUF4782)

  2. XM_021473759.2 → XP_021329434.1  protein Aster-C

    UniProtKB/TrEMBL
    A0A8M9Q853
    Conserved Domains (2) summary
    cd13220
    Location:95 → 187
    PH-GRAM_GRAMDC; GRAM domain-containing protein (GRAMDC) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
    pfam16016
    Location:357 → 505
    DUF4782; Domain of unknown function (DUF4782)
Nucleotide Protein
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