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Stam2 signal transducing adaptor molecule (SH3 domain and ITAM motif) 2 [ Mus musculus (house mouse) ]

Gene ID: 56324, updated on 27-Nov-2024

Summary

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Official Symbol
Stam2provided by MGI
Official Full Name
signal transducing adaptor molecule (SH3 domain and ITAM motif) 2provided by MGI
Primary source
MGI:MGI:1929100
See related
Ensembl:ENSMUSG00000055371 AllianceGenome:MGI:1929100
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Hbp; 1200004O12Rik; 5730456G07Rik
Summary
Predicted to enable phosphatidylinositol binding activity and ubiquitin binding activity. Predicted to be involved in signal transduction. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in endocytic vesicle. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; heart; and skin. Orthologous to human STAM2 (signal transducing adaptor molecule 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in CNS E18 (RPKM 8.5), testis adult (RPKM 7.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Stam2 in Genome Data Viewer
Location:
2 C1.1; 2 30.41 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (52582213..52632212, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (52692206..52742149, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene calcium channel, voltage-dependent, beta 4 subunit Neighboring gene STARR-seq mESC enhancer starr_04484 Neighboring gene biogenesis of lysosomal organelles complex-1, subunit 2, pseudogene Neighboring gene STARR-seq mESC enhancer starr_04486 Neighboring gene predicted gene, 46740 Neighboring gene STARR-positive B cell enhancer ABC_E7814 Neighboring gene predicted gene, 46741 Neighboring gene STARR-positive B cell enhancer ABC_E10102 Neighboring gene STARR-seq mESC enhancer starr_04490 Neighboring gene formin-like 2 Neighboring gene STARR-seq mESC enhancer starr_04498 Neighboring gene STARR-seq mESC enhancer starr_04499 Neighboring gene predicted gene, 52511 Neighboring gene STARR-positive B cell enhancer ABC_E1005 Neighboring gene pre-mRNA processing factor 40A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. STAM2, a member of the endosome-associated complex ESCRT-0 is highly expressed in neurons. Kapuralin K, et al. Mol Cell Neurosci, 2015 Jul. PMID 26101075
  2. Stam2 expression pattern during embryo development. Curlin M, et al. Gene Expr Patterns, 2012 Jan-Feb. PMID 22143071
  3. Splice variant of mouse Stam2 mRNA in nervous and muscle tissue contains additional exon with stop codon within region coding for VHS domain. Curlin M, et al. Croat Med J, 2006 Feb. PMID 16489693, Free PMC Article
  4. Expression pattern and functional analysis of mouse Stam2 in the olfactory system. Furić Cunko V, et al. Coll Antropol, 2008 Jan. PMID 18405059
  5. Signal-transducing adaptor molecules STAM1 and STAM2 are required for T-cell development and survival. Yamada M, et al. Mol Cell Biol, 2002 Dec. PMID 12446783, Free PMC Article

See all (41) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Stam2 is expressed in the nervous tissue, heart, digestive and endocrine system during embryo development.
    Title: Stam2 expression pattern during embryo development.
  2. These results demonstrate that the STAMs are indispensably involved in T-cell development and survival in the thymus through the prevention of apoptosis but are dispensable for the proximal signaling of TCR and cytokine receptors.
    Title: Signal-transducing adaptor molecules STAM1 and STAM2 are required for T-cell development and survival.
  3. SH3 domains of STAM2 and Grb2 retain the moderate characteristics of recognizing their ligand proteins like other SH3 domains for signal protein binding
    Title: Structural insight into modest binding of a non-PXXP ligand to the signal transducing adaptor molecule-2 Src homology 3 domain.
  4. plays important role in the mammalian endosomal/vacuolar protein sorting pathway
    Title: Effects of deficiencies of STAMs and Hrs, mammalian class E Vps proteins, on receptor downregulation.
  5. STAM proteins function in a multivalent complex that sorts ubiquitinated proteins into the multivesicular body pathway.
    Title: STAM and Hrs are subunits of a multivalent ubiquitin-binding complex on early endosomes.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables phosphatidylinositol binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in early endosome membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in endocytic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
signal transducing adapter molecule 2
Names
Hrs binding protein
STAM-2
hrs-binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001418464.1 → NP_001405393.1  signal transducing adapter molecule 2 isoform b

    Status: VALIDATED

    Source sequence(s)
    AL928960

  2. NM_001418465.1 → NP_001405394.1  signal transducing adapter molecule 2 isoform b

    Status: VALIDATED

    Source sequence(s)
    AL928960

  3. NM_001418466.1 → NP_001405395.1  signal transducing adapter molecule 2 isoform c

    Status: VALIDATED

    Source sequence(s)
    AL928960
    Related
    ENSMUSP00000121898.2, ENSMUST00000127316.8

  4. NM_001418467.1 → NP_001405396.1  signal transducing adapter molecule 2 isoform d

    Status: VALIDATED

    Source sequence(s)
    AL928960

  5. NM_019667.3 → NP_062641.1  signal transducing adapter molecule 2 isoform a

    See identical proteins and their annotated locations for NP_062641.1

    Status: VALIDATED

    Source sequence(s)
    AL928960
    Consensus CDS
    CCDS16037.1
    UniProtKB/Swiss-Prot
    A2AU00, O88811, Q8C8Y4
    UniProtKB/TrEMBL
    Q3TGH8
    Related
    ENSMUSP00000099820.2, ENSMUST00000102759.8
    Conserved Domains (4) summary
    cd11963
    Location:204 → 260
    SH3_STAM2; Src homology 3 domain of Signal Transducing Adaptor Molecule 2
    cd03568
    Location:9 → 143
    VHS_STAM; VHS domain family, STAM subfamily; members include STAM (Signal Transducing Adaptor Molecule), EAST (EGFR-associated protein with SH3 and TAM domains) and Hbp (Hrs-binding protein). Collectively, they are referred to as STAM. All STAMs have at their ...
    pfam02809
    Location:166 → 181
    UIM; Ubiquitin interaction motif
    pfam03127
    Location:294 → 367
    GAT; GAT domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    52582213..52632212 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O88811.1 GenPept UniProtKB/Swiss-Prot:O88811

Gene LinkOut

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