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ap3b1a adaptor related protein complex 3 subunit beta 1a [ Danio rerio (zebrafish) ]

Gene ID: 563316, updated on 4-Jan-2025

Summary

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Official Symbol
ap3b1aprovided by ZNC
Official Full Name
adaptor related protein complex 3 subunit beta 1aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-031112-8
See related
AllianceGenome:ZFIN:ZDB-GENE-031112-8
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
ap3b1; cb964
Summary
Predicted to act upstream of or within intracellular protein transport and vesicle-mediated transport. Predicted to be located in clathrin-coated vesicle membrane. Predicted to be part of AP-3 adaptor complex and clathrin adaptor complex. Is expressed in several structures, including axial vasculature; intermediate cell mass of mesoderm; optic vesicle; ventral mesoderm; and yolk syncytial layer. Human ortholog(s) of this gene implicated in Hermansky-Pudlak syndrome; Hermansky-Pudlak syndrome 2; interstitial lung disease; neutropenia; and pulmonary fibrosis. Orthologous to human AP3B1 (adaptor related protein complex 3 subunit beta 1). [provided by Alliance of Genome Resources, Jan 2025]
Annotation information
Annotation category: partial on reference assembly
Orthologs
human mouse all
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Genomic context

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See ap3b1a in Genome Data Viewer
Location:
chromosome: 21
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (7298573..7440389)
105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (6483810..6601285, complement)

Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene 1-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic acid acyltransferase, beta) Neighboring gene EGF-like-domain, multiple 7 Neighboring gene microRNA mir-126b Neighboring gene uncharacterized LOC110438212 Neighboring gene uncharacterized LOC137488780

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Genetic characterization and in vivo image analysis of novel zebrafish Danio rerio pigment mutants. Hsu CC, et al. J Fish Biol, 2013 May. PMID 23639161
  2. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
  5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Process Evidence Code Pubs
acts_upstream_of_or_within intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of AP-3 adaptor complex IEA
Inferred from Electronic Annotation
more info
  
part_of clathrin adaptor complex IEA
Inferred from Electronic Annotation
more info
  
located_in clathrin-coated vesicle membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
part_of membrane coat IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
AP-3 complex subunit beta-1
Names
adaptor related protein complex 3 beta 1 subunit
adaptor-related protein complex 3, beta 1 subunit a

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007132.7 Reference GRCz11 Primary Assembly

    Range
    7298573..7440389
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021469001.2 → XP_021324676.1  AP-3 complex subunit beta-1

    UniProtKB/TrEMBL
    A0A8M9PQW2
    Conserved Domains (3) summary
    sd00044
    Location:124 → 152
    HEAT; HEAT repeat [structural motif]
    pfam01602
    Location:54 → 587
    Adaptin_N; Adaptin N terminal region
    pfam14796
    Location:832 → 974
    AP3B1_C; Clathrin-adaptor complex-3 beta-1 subunit C-terminal
Nucleotide Protein Strain
Heading Accession and Version

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