smurf2 SMAD specific E3 ubiquitin protein ligase 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: smurf2provided by ZNC
Official Full Name: SMAD specific E3 ubiquitin protein ligase 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-1830
See related: Ensembl:ENSDARG00000038067 AllianceGenome:ZFIN:ZDB-GENE-030131-1830
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: wu:fb82a11; wu:fc41c02
Summary: Predicted to enable SMAD binding activity and ubiquitin protein ligase activity. Predicted to be involved in negative regulation of BMP signaling pathway and proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to act upstream of or within ubiquitin-dependent protein catabolic process. Predicted to be located in membrane raft; nucleus; and plasma membrane. Predicted to be active in cytoplasm. Is expressed in female organism and male organism. Orthologous to human SMURF2 (SMAD specific E3 ubiquitin protein ligase 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 3

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	3	NC_007114.7 (25281947..25369583, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	3	NC_007114.6 (25151399..25239291, complement)

Chromosome 3 - NC_007114.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Expression Levels of SMAD Specific E3 Ubiquitin Protein Ligase 2 (Smurf2) and its Interacting Partners Show Region-specific Alterations During Brain Aging.
Title: Expression Levels of SMAD Specific E3 Ubiquitin Protein Ligase 2 (Smurf2) and its Interacting Partners Show Region-specific Alterations During Brain Aging.

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General gene information

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Markers

fk27h09.y1 (e-PCR)
- UniSTS:200742

fb43e01.x1 (e-PCR)
- UniSTS:190577

fb82a11.y1 (e-PCR)
- UniSTS:191667

fc41c02.x1 (e-PCR)
- UniSTS:188136

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables SMAD binding	IBA Inferred from Biological aspect of Ancestor more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin-protein transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in negative regulation of BMP signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane raft	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: E3 ubiquitin-protein ligase SMURF2

Names: HECT-type E3 ubiquitin transferase SMURF2; SMAD ubiquitination regulatory factor 2

NP_001107898.1

EC 2.3.2.26

XP_068073413.1

EC 2.3.2.26

XP_068073416.1

EC 2.3.2.26

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001114426.1 → NP_001107898.1 E3 ubiquitin-protein ligase SMURF2

See identical proteins and their annotated locations for NP_001107898.1

Status: PROVISIONAL

Source sequence(s)

BC155849

UniProtKB/Swiss-Prot

A9JRZ0

Related

ENSDARP00000055490.4, ENSDART00000055491.6

Conserved Domains (5) summary

cd08382
Location:13 → 137

C2_Smurf-like; C2 domain present in Smad ubiquitination-related factor (Smurf)-like proteins

smart00456
Location:298 → 330

WW; Domain with 2 conserved Trp (W) residues

smart00119
Location:437 → 762

HECTc; Domain Homologous to E6-AP Carboxyl Terminus with

cd00078
Location:410 → 762

HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

pfam00397
Location:159 → 188

WW; WW domain