Chp1 calcineurin-like EF hand protein 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Chp1provided by MGI
Official Full Name: calcineurin-like EF hand protein 1provided by MGI
Primary source: MGI:MGI:1927185
See related: Ensembl:ENSMUSG00000014077 AllianceGenome:MGI:1927185
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Chp; p24; vac; Cahp; Sid470p; 1500003O03Rik
Summary: Enables sodium:proton antiporter activity. Predicted to be involved in several processes, including microtubule cytoskeleton organization; regulation of establishment of protein localization; and regulation of protein modification process. Part of transporter complex. Is active in membrane raft. Is expressed in genitourinary system. Human ortholog(s) of this gene implicated in spastic ataxia. Orthologous to human CHP1 (calcineurin like EF-hand protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in subcutaneous fat pad adult (RPKM 137.3), mammary gland adult (RPKM 107.2) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 E5; 2 59.97 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (119378172..119417505)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (119547707..119587024)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

This study demonistrated that CHP1-mediated NHE1 biosynthetic maturation is required for Purkinje cell axon homeostasis.
Title: CHP1-mediated NHE1 biosynthetic maturation is required for Purkinje cell axon homeostasis.
CHP2 has a role in tumorigenesis and as an activator of the calcineurin/NFAT signaling pathway
Title: CHP2 activates the calcineurin/nuclear factor of activated T cells signaling pathway and enhances the oncogenic potential of HEK293 cells.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AA960066 (e-PCR)
- UniSTS:160552

D18051 (e-PCR)
- UniSTS:124766

38.MMHAP33FRE11.seq (e-PCR)
- UniSTS:124271

AI046351 (e-PCR)
- UniSTS:180889

RH143965 (e-PCR)
- UniSTS:233211

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables calcium ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables calcium-dependent protein binding	ISO Inferred from Sequence Orthology more info
enables calcium-dependent protein binding	ISS Inferred from Sequence or Structural Similarity more info
enables kinase binding	ISO Inferred from Sequence Orthology more info
enables kinase binding	ISS Inferred from Sequence or Structural Similarity more info
enables microtubule binding	ISO Inferred from Sequence Orthology more info
enables microtubule binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein kinase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables sodium:proton antiporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables sodium:proton antiporter activity	ISO Inferred from Sequence Orthology more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to acidic pH	ISS Inferred from Sequence or Structural Similarity more info
involved_in cytoplasmic microtubule organization	ISO Inferred from Sequence Orthology more info
involved_in cytoplasmic microtubule organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in membrane docking	IBA Inferred from Biological aspect of Ancestor more info
involved_in membrane docking	ISO Inferred from Sequence Orthology more info
involved_in membrane docking	ISS Inferred from Sequence or Structural Similarity more info
involved_in membrane fusion	ISO Inferred from Sequence Orthology more info
involved_in membrane fusion	ISS Inferred from Sequence or Structural Similarity more info
involved_in membrane organization	ISO Inferred from Sequence Orthology more info
involved_in membrane organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in microtubule bundle formation	ISO Inferred from Sequence Orthology more info
involved_in microtubule bundle formation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of NF-kappaB transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of NF-kappaB transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of calcineurin-NFAT signaling cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of calcineurin-NFAT signaling cascade	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of calcineurin-NFAT signaling cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of phosphatase activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of protein autophosphorylation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein autophosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of protein import into nucleus	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein import into nucleus	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of protein kinase activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein phosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein ubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of phospholipid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of phospholipid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein glycosylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein glycosylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of protein targeting to membrane	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of protein transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of sodium:proton antiporter activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of sodium:proton antiporter activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein complex oligomerization	ISO Inferred from Sequence Orthology more info
involved_in protein export from nucleus	ISO Inferred from Sequence Orthology more info
involved_in protein export from nucleus	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein stabilization	ISO Inferred from Sequence Orthology more info
involved_in protein stabilization	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of intracellular pH	ISO Inferred from Sequence Orthology more info
involved_in regulation of intracellular pH	ISS Inferred from Sequence or Structural Similarity more info
involved_in sodium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in vesicle fusion	ISO Inferred from Sequence Orthology more info
involved_in vesicle targeting	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi membrane	ISO Inferred from Sequence Orthology more info
located_in Golgi membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum-Golgi intermediate compartment	IEA Inferred from Electronic Annotation more info
is_active_in membrane raft	IPI Inferred from Physical Interaction more info	PubMed
located_in microtubule cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in microtubule cytoskeleton	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in transport vesicle	ISO Inferred from Sequence Orthology more info
located_in transport vesicle	ISS Inferred from Sequence or Structural Similarity more info
part_of transporter complex	IDA Inferred from Direct Assay more info	PubMed
part_of transporter complex	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: calcineurin B homologous protein 1

Names: EF-hand calcium-binding domain-containing protein p22; calcineurin B-like protein; calcineurin homologous protein; calcium binding protein P22; calcium-binding protein CHP; calcium-binding protein p22; sid 470

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019769.3 → NP_062743.1 calcineurin B homologous protein 1

See identical proteins and their annotated locations for NP_062743.1

Status: VALIDATED

Source sequence(s)

AK166219, BC054733, BY268484

Consensus CDS

CCDS16604.1

UniProtKB/Swiss-Prot

P61022, Q62877, Q6ZWQ8

UniProtKB/TrEMBL

B0R091

Related

ENSMUSP00000014221.7, ENSMUST00000014221.13

Conserved Domains (1) summary

COG5126
Location:1 → 182

FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

119378172..119417505

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036162411.1 → XP_036018304.1 calcineurin B homologous protein 1 isoform X1

Conserved Domains (2) summary

COG5126
Location:1 → 155

FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

cd00051
Location:87 → 153

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...