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Syncrip synaptotagmin binding, cytoplasmic RNA interacting protein [ Mus musculus (house mouse) ]

Gene ID: 56403, updated on 27-Nov-2024

Summary

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Official Symbol
Syncripprovided by MGI
Official Full Name
synaptotagmin binding, cytoplasmic RNA interacting proteinprovided by MGI
Primary source
MGI:MGI:1891690
See related
Ensembl:ENSMUSG00000032423 AllianceGenome:MGI:1891690
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
pp68; Nsap1; Nsap1l; GRY-RBP; hnRNP Q; 2610109K23Rik; 4632417O19Rik
Summary
Enables poly(A) binding activity. Predicted to be involved in several processes, including cellular response to type II interferon; negative regulation of mRNA metabolic process; and regulation of translation. Located in cytoplasm. Part of histone pre-mRNA 3'end processing complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Orthologous to human SYNCRIP (synaptotagmin binding cytoplasmic RNA interacting protein). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in CNS E11.5 (RPKM 10.8), limb E14.5 (RPKM 9.0) and 21 other tissues See more
Orthologs
human all
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Genomic context

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See Syncrip in Genome Data Viewer
Location:
9 E3.1; 9 47.24 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (88331417..88364645, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (88449364..88482591, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_24855 Neighboring gene 5' nucleotidase, ecto Neighboring gene sorting nexin 14 Neighboring gene 60S ribosomal protein L21 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E10573 Neighboring gene STARR-seq mESC enhancer starr_24856 Neighboring gene STARR-positive B cell enhancer ABC_E9772 Neighboring gene small nucleolar RNA, C/D box 50A Neighboring gene small nucleolar RNA, C/D box 50B Neighboring gene small nucleolar RNA host gene 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The RNA-Binding Protein SYNCRIP Is a Component of the Hepatocyte Exosomal Machinery Controlling MicroRNA Sorting. Santangelo L, et al. Cell Rep, 2016 Oct 11. PMID 27732855
  2. hnRNP Q regulates translation of p53 in normal and stress conditions. Kim DY, et al. Cell Death Differ, 2013 Feb. PMID 22935615, Free PMC Article
  3. hnRNP Q Regulates Internal Ribosome Entry Site-Mediated fmr1 Translation in Neurons. Choi JH, et al. Mol Cell Biol, 2019 Feb 15. PMID 30478144, Free PMC Article
  4. SYNCRIP Modulates the Epithelial-Mesenchymal Transition in Hepatocytes and HCC Cells. Riccioni V, et al. Int J Mol Sci, 2022 Jan 14. PMID 35055098, Free PMC Article
  5. RNA binding protein SYNCRIP maintains proteostasis and self-renewal of hematopoietic stem and progenitor cells. Herrejon Chavez F, et al. Nat Commun, 2023 Apr 21. PMID 37085479, Free PMC Article

See all (79) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. RNA binding protein SYNCRIP maintains proteostasis and self-renewal of hematopoietic stem and progenitor cells.
    Title: RNA binding protein SYNCRIP maintains proteostasis and self-renewal of hematopoietic stem and progenitor cells.
  2. SYNCRIP Modulates the Epithelial-Mesenchymal Transition in Hepatocytes and HCC Cells.
    Title: SYNCRIP Modulates the Epithelial-Mesenchymal Transition in Hepatocytes and HCC Cells.
  3. hnRNP Q and hnRNP A1 Regulate the Translation of Cofilin in Response to Transient Oxygen-Glucose Deprivation in Hippocampal Neurons.
    Title: hnRNP Q and hnRNP A1 Regulate the Translation of Cofilin in Response to Transient Oxygen-Glucose Deprivation in Hippocampal Neurons.
  4. these results provide new insights into how neuronal HNRNP Q decreases VRK2 mRNA stability and contributes to the prevention of Huntington's disease
    Title: HNRNP Q suppresses polyglutamine huntingtin aggregation by post-transcriptional regulation of vaccinia-related kinase 2.
  5. results suggest that hnRNP Q plays a pivotal role in both Bmal1 translation and BMAL1-regulated gene expression.
    Title: The RNA-binding protein hnRNP Q represses translation of the clock gene Bmal1 in murine cells.
  6. Semaphorin 3A (Sema3A)-induced axonal growth cone collapse is due to upregulation of hnRNP Q and subsequent IRES-mediated expression of FMRP.
    Title: hnRNP Q Regulates Internal Ribosome Entry Site-Mediated fmr1 Translation in Neurons.
  7. SYNCRIP (synaptotagmin-binding cytoplasmic RNA-interacting protein; also known as hnRNP-Q or NSAP1) is a component of the hepatocyte exosomal miRNA sorting machinery.
    Title: The RNA-Binding Protein SYNCRIP Is a Component of the Hepatocyte Exosomal Machinery Controlling MicroRNA Sorting.
  8. SYNCRIP is required to maintain myeloid leukemia survival.
    Title: Functional screen of MSI2 interactors identifies an essential role for SYNCRIP in myeloid leukemia stem cells.
  9. hnRNP Q binds to mCry1 mRNA via the 5'UTR. Furthermore, hnRNP Q inhibits the translation of mCry1 mRNA, leading to altered rhythmicity in the mCRY1 protein profile.
    Title: HnRNP Q Has a Suppressive Role in the Translation of Mouse Cryptochrome1.
  10. hnRNP-Q1-mediated repression of Gap-43 mRNA translation provides an additional mechanism for regulating GAP-43 expression and function and may be critical for neuronal development.
    Title: hnRNP-Q1 represses nascent axon growth in cortical neurons by inhibiting Gap-43 mRNA translation.
Submit: New GeneRIF Correction See all GeneRIFs (18)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (3) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables mRNA 3'-UTR binding ISO
Inferred from Sequence Orthology
more info
  
enables mRNA 5'-UTR binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mRNA 5'-UTR binding ISO
Inferred from Sequence Orthology
more info
  
enables poly(A) binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in CRD-mediated mRNA stabilization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in CRD-mediated mRNA stabilization ISO
Inferred from Sequence Orthology
more info
  
involved_in RNA splicing IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to type II interferon ISO
Inferred from Sequence Orthology
more info
  
involved_in chromosomal 5-methylcytosine DNA demethylation pathway NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in mRNA modification ISO
Inferred from Sequence Orthology
more info
  
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of mRNA modification ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of translation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cytoplasmic translation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of translation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of CRD-mediated mRNA stability complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of CRD-mediated mRNA stability complex ISO
Inferred from Sequence Orthology
more info
  
part_of CRD-mediated mRNA stability complex ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of GAIT complex ISO
Inferred from Sequence Orthology
more info
  
part_of catalytic step 2 spliceosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
part_of histone pre-mRNA 3'end processing complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of mCRD-mediated mRNA stability complex ISO
Inferred from Sequence Orthology
more info
  
part_of mRNA editing complex NAS
Non-traceable Author Statement
more info
 PubMed 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in proximal dendrite ISO
Inferred from Sequence Orthology
more info
  
part_of ribonucleoprotein complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ribonucleoprotein complex ISO
Inferred from Sequence Orthology
more info
  
part_of ribonucleoprotein complex ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of spliceosomal complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
heterogeneous nuclear ribonucleoprotein Q
Names
NS1-associated protein 1
RRM RNA binding protein GRY-RBP
glycine- and tyrosine-rich RNA-binding protein
hnRNP-Q

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001284328.1 → NP_001271257.1  heterogeneous nuclear ribonucleoprotein Q isoform 3

    See identical proteins and their annotated locations for NP_001271257.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses a distinct 3' terminal exon and differs in the 3' coding region and 3' UTR, compared to variant 1. The resulting protein (isoform 3) is shorter and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    BC080309, CT025673
    Consensus CDS
    CCDS72292.1
    UniProtKB/TrEMBL
    A0A0R4J259, G3UZI2
    Related
    ENSMUSP00000134071.2, ENSMUST00000174282.8
    Conserved Domains (2) summary
    TIGR01648
    Location:103 → 553
    hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family
    cd21066
    Location:23 → 107
    NURR_hnRNPQ; NURR (N-terminal unit for RNA recognition) domain found in heterogeneous nuclear ribonucleoprotein Q (hnRNPQ) and similar proteins

  2. NM_001311113.1 → NP_001298042.1  heterogeneous nuclear ribonucleoprotein Q isoform 4

    See identical proteins and their annotated locations for NP_001298042.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' and 3' UTRs and has multiple coding region differences compared to variant 1. The resulting isoform (4) has a shorter N-terminus, a distinct C-terminus, and is shorter than isoform 1.
    Source sequence(s)
    AK034845, AK078158, AK083398, BC050079, BY234240, CT025673
    Consensus CDS
    CCDS81048.1
    UniProtKB/TrEMBL
    G3UZ48, G3UZI2
    Related
    ENSMUSP00000134342.2, ENSMUST00000174391.8
    Conserved Domains (1) summary
    TIGR01648
    Location:5 → 459
    hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family

  3. NM_019666.2 → NP_062640.2  heterogeneous nuclear ribonucleoprotein Q isoform 1

    See identical proteins and their annotated locations for NP_062640.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest protein (isoform 1).
    Source sequence(s)
    AK162448, BQ559204, BU505018, CN529994, CV562339
    Consensus CDS
    CCDS57686.1
    UniProtKB/Swiss-Prot
    O88991, Q2YDV8, Q68ED6, Q7TMK9, Q80YV6, Q8BGP1, Q8C5K6, Q8CGC2, Q91ZR0, Q99KU9, Q9QYF4
    UniProtKB/TrEMBL
    G3V018
    Related
    ENSMUSP00000133649.2, ENSMUST00000173801.8
    Conserved Domains (2) summary
    TIGR01648
    Location:103 → 615
    hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family
    pfam18360
    Location:34 → 103
    hnRNP_Q_AcD; Heterogeneous nuclear ribonucleoprotein Q acidic domain

  4. NM_019796.5 → NP_062770.1  heterogeneous nuclear ribonucleoprotein Q isoform 2

    See identical proteins and their annotated locations for NP_062770.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses a distinct 3' terminal exon and differs in the 3' coding region and 3' UTR, compared to variant 1. The resulting protein (isoform 2) is shorter and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AK034845, CT025673
    Consensus CDS
    CCDS23388.1
    UniProtKB/TrEMBL
    G3UZI2
    Related
    ENSMUSP00000063744.6, ENSMUST00000069221.12
    Conserved Domains (2) summary
    TIGR01648
    Location:103 → 557
    hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family
    cd21066
    Location:23 → 107
    NURR_hnRNPQ; NURR (N-terminal unit for RNA recognition) domain found in heterogeneous nuclear ribonucleoprotein Q (hnRNPQ) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    88331417..88364645 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006511293.5 → XP_006511356.1  heterogeneous nuclear ribonucleoprotein Q isoform X1

    UniProtKB/TrEMBL
    G3V018
    Conserved Domains (2) summary
    TIGR01648
    Location:103 → 592
    hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family
    pfam18360
    Location:34 → 103
    hnRNP_Q_AcD; Heterogeneous nuclear ribonucleoprotein Q acidic domain

  2. XM_006511294.3 → XP_006511357.1  heterogeneous nuclear ribonucleoprotein Q isoform X2

    UniProtKB/TrEMBL
    G3V018
    Conserved Domains (1) summary
    TIGR01648
    Location:5 → 517
    hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7TMK9.2 GenPept UniProtKB/Swiss-Prot:Q7TMK9

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