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Trpc4ap transient receptor potential cation channel, subfamily C, member 4 associated protein [ Mus musculus (house mouse) ]

Gene ID: 56407, updated on 27-Nov-2024

Summary

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Official Symbol
Trpc4approvided by MGI
Official Full Name
transient receptor potential cation channel, subfamily C, member 4 associated proteinprovided by MGI
Primary source
MGI:MGI:1930751
See related
Ensembl:ENSMUSG00000038324 AllianceGenome:MGI:1930751
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
truss; Trrp4ap; mFLJ00177; D2Ertd113e; 4833429F06Rik
Summary
Predicted to enable phosphatase binding activity and ubiquitin-like ligase-substrate adaptor activity. Acts upstream of or within hair follicle maturation. Predicted to be located in perinuclear region of cytoplasm. Predicted to be part of Cul4A-RING E3 ubiquitin ligase complex. Is expressed in cerebral cortex ventricular layer and cortical plate. Orthologous to human TRPC4AP (transient receptor potential cation channel subfamily C member 4 associated protein). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in thymus adult (RPKM 93.7), ovary adult (RPKM 61.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Trpc4ap in Genome Data Viewer
Location:
2 H1; 2 77.26 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (155476197..155534304, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (155634277..155692384, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene glutathione synthase, opposite strand 2 Neighboring gene glutathione synthetase Neighboring gene STARR-seq mESC enhancer starr_06145 Neighboring gene STARR-positive B cell enhancer ABC_E6005 Neighboring gene myosin, heavy chain 7B, cardiac muscle, beta Neighboring gene microRNA 499 Neighboring gene predicted gene, 22334 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:155505379-155505532 Neighboring gene ER degradation enhancer, mannosidase alpha-like 2 Neighboring gene STARR-positive B cell enhancer ABC_E10157 Neighboring gene STARR-seq mESC enhancer starr_06149 Neighboring gene protein C receptor, endothelial

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. TRUSS inhibition protects against high fat diet (HFD)-stimulated brain injury by alleviation of inflammatory response. Zhu Q, et al. Biochem Biophys Res Commun, 2019 Mar 26. PMID 30765221
  2. TRUSS Exacerbates NAFLD Development by Promoting IκBα Degradation in Mice. Yu CJ, et al. Hepatology, 2018 Nov. PMID 29704259
  3. TRUSS, a novel tumor necrosis factor receptor 1 scaffolding protein that mediates activation of the transcription factor NF-kappaB. Soond SM, et al. Mol Cell Biol, 2003 Nov. PMID 14585990, Free PMC Article
  4. Identification of genes important for cutaneous function revealed by a large scale reverse genetic screen in the mouse. DiTommaso T, et al. PLoS Genet, 2014 Oct. PMID 25340873, Free PMC Article
  5. Mouse screen reveals multiple new genes underlying mouse and human hearing loss. Ingham NJ, et al. PLoS Biol, 2019 Apr. PMID 30973865, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TRUSS ablation alleviates high fat diet -induced cognitive impairments and metabolic disorder.
    Title: TRUSS inhibition protects against high fat diet (HFD)-stimulated brain injury by alleviation of inflammatory response.
  2. Hepatocyte TRUSS promotes pathological stimuli-induced non alcoholic fatty liver disease and metabolic disorders, through activation of NF-kappaB by promoting ubiquitination and degradation of IkappaBalpha
    Title: TRUSS Exacerbates NAFLD Development by Promoting IκBα Degradation in Mice.
  3. cloning and characterization of tumor necrosis factor receptor 1 (TNF-R1)-associated ubiquitous scaffolding and signaling protein (TRUSS)
    Title: TRUSS, a novel tumor necrosis factor receptor 1 scaffolding protein that mediates activation of the transcription factor NF-kappaB.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1)  1 citation
  • Targeted (1) 

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • FLJ00177

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables phosphatase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatase binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatase binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables ubiquitin-like ligase-substrate adaptor activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin-like ligase-substrate adaptor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within hair follicle maturation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein ubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in ubiquitin-dependent protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in ubiquitin-dependent protein catabolic process via the C-end degron rule pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in ubiquitin-dependent protein catabolic process via the C-end degron rule pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of Cul4-RING E3 ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  
part_of Cul4-RING E3 ubiquitin ligase complex ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of Cul4A-RING E3 ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Cul4A-RING E3 ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  
part_of Cul4A-RING E3 ubiquitin ligase complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
short transient receptor potential channel 4-associated protein
Names
TNF-receptor ubiquitous scaffolding/signaling protein
Trp4-associated protein TAP1
rabex-5/Rin2-interacting protein
transient receptor protein 4, associated protein
trpc4-associated protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163452.1 → NP_001156924.1  short transient receptor potential channel 4-associated protein isoform 1

    See identical proteins and their annotated locations for NP_001156924.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK171404, AL844852, BC057330
    Consensus CDS
    CCDS50769.1
    UniProtKB/Swiss-Prot
    Q920J6, Q99L03, Q9JLV2
    UniProtKB/TrEMBL
    Q3TDP6, Q571F0
    Related
    ENSMUSP00000037574.6, ENSMUST00000041059.12
    Conserved Domains (1) summary
    pfam12463
    Location:407 → 713
    DUF3689; Protein of unknown function (DUF3689)

  2. NM_019828.2 → NP_062802.2  short transient receptor potential channel 4-associated protein isoform 2

    See identical proteins and their annotated locations for NP_062802.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region compared to variant 1. The resulting protein (isoform 2) is shorter but has the same N- and C-termini as isoform 1.
    Source sequence(s)
    AK171404, AL844852, BC057330
    Consensus CDS
    CCDS16952.1
    UniProtKB/TrEMBL
    Q571F0
    Related
    ENSMUSP00000099429.5, ENSMUST00000103140.5
    Conserved Domains (1) summary
    pfam12463
    Location:399 → 705
    DUF3689; Protein of unknown function (DUF3689)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    155476197..155534304 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9JLV2.2 GenPept UniProtKB/Swiss-Prot:Q9JLV2

Gene LinkOut

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