mki67 marker of proliferation Ki-67 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: mki67provided by ZNC
Official Full Name: marker of proliferation Ki-67provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-9771
See related: Ensembl:ENSDARG00000091150 AllianceGenome:ZFIN:ZDB-GENE-030131-9771
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cb31; sb:cb31; wu:fa11g09; wu:fb57a07; wu:fi14e05; si:ch211-250b22.7
Summary: Predicted to be involved in regulation of chromosome segregation and regulation of mitotic nuclear division. Predicted to be active in chromosome and nucleus. Is expressed in several structures, including blood; head; pectoral fin bud; pectoral fin musculature; and ventral mesoderm. Human ortholog(s) of this gene implicated in several diseases, including Crohn's disease; colorectal cancer; endocrine gland cancer (multiple); graft-versus-host disease; and human immunodeficiency virus infectious disease. Orthologous to human MKI67 (marker of proliferation Ki-67). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: chromosome: 12

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	12	NC_007123.7 (10367835..10381070, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	12	NC_007123.6 (10329992..10343222, complement)

Chromosome 12 - NC_007123.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

fb57a07.x1 (e-PCR)
- UniSTS:190750

fi29c09.y1 (e-PCR)
- UniSTS:197201

fb57a07 (e-PCR)
- UniSTS:187221

aa494721 (e-PCR)
- UniSTS:186799

fc48b09.y1 (e-PCR)
- UniSTS:193977

fa04b08.s1 (e-PCR)
- UniSTS:202188

fd22h07.y1 (e-PCR)
- UniSTS:195297

AA495166 (e-PCR)
- UniSTS:186850

fi14e05.x1 (e-PCR)
- UniSTS:196852

Gene Ontology Provided by ZFIN

Process	Evidence Code	Pubs
involved_in regulation of chromosome segregation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of mitotic nuclear division	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in chromosome	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: proliferation marker protein Ki-67

Names: antigen KI-67-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001277446.2 → NP_001264375.1 proliferation marker protein Ki-67

Status: VALIDATED

Source sequence(s)

CR848037, CT730715, CU104767

UniProtKB/TrEMBL

A0A8M1NZY3, E7F3N4

Related

ENSDARP00000126723.1, ENSDART00000152788.2

Conserved Domains (4) summary

cd00060
Location:8 → 99

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

pfam08065
Location:960 → 1058

K167R; K167R (NUC007) repeat

pfam15276
Location:447 → 484

PP1_bind; Protein phosphatase 1 binding

cl26511
Location:1485 → 2042

Neuromodulin_N; Gap junction protein N-terminal region