cpxm1a carboxypeptidase X (M14 family), member 1a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: cpxm1aprovided by ZNC
Official Full Name: carboxypeptidase X (M14 family), member 1aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-5284
See related: Ensembl:ENSDARG00000073716 AllianceGenome:ZFIN:ZDB-GENE-030131-5284
Gene type: protein coding
RefSeq status: MODEL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fa25h05; wu:fa25h05; si:dkey-19p15.7
Summary: Predicted to enable metallocarboxypeptidase activity and zinc ion binding activity. Predicted to be involved in anatomical structure morphogenesis. Predicted to act upstream of or within proteolysis. Predicted to be active in extracellular space. Orthologous to human CPXM1 (carboxypeptidase X, M14 family member 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: chromosome: 13

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	13	NC_007124.7 (9575516..9608872, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	13	NC_007124.6 (9243493..9276868, complement)

Chromosome 13 - NC_007124.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

G39172 (e-PCR)
- UniSTS:36481

fa25h05.s1 (e-PCR)
- UniSTS:202484

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables carboxypeptidase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metallocarboxypeptidase activity	IEA Inferred from Electronic Annotation more info
enables peptidase activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in anatomical structure morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: probable carboxypeptidase X1

Names: carboxypeptidase X, member 1

XP_021336422.1

EC 3.4.17.10

XP_693256.4

EC 3.4.17.10

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007124.7 Reference GRCz11 Primary Assembly

Range

9575516..9608872 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021480747.2 → XP_021336422.1 probable carboxypeptidase X1

UniProtKB/TrEMBL

A0A0R4I9C2, A0A8M9PYE2

Related

ENSDARP00000058065.6, ENSDART00000058066.7

Conserved Domains (3) summary

cd03869
Location:258 → 582

M14_CPX_like; Peptidase M14 carboxypeptidase subfamily N/E-like; Carboxypeptidase X subgroup

cd11308
Location:586 → 662

Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain

cd00057
Location:81 → 236

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

Reference GRCz11 ALT_DRER_TU_1

Genomic

NW_018394866.1 Reference GRCz11 ALT_DRER_TU_1

Range

235899..269255 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_688164.8 → XP_693256.4 probable carboxypeptidase X1

UniProtKB/TrEMBL

A0A0R4I9C2, A0A8M9PYE2

Conserved Domains (3) summary

cd03869
Location:258 → 582

M14_CPX_like; Peptidase M14 carboxypeptidase subfamily N/E-like; Carboxypeptidase X subgroup

cd11308
Location:586 → 662

Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain

cd00057
Location:81 → 236

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.