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cel.2 carboxyl ester lipase, tandem duplicate 2 [ Danio rerio (zebrafish) ]

Gene ID: 565117, updated on 4-Jan-2025

Summary

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Official Symbol
cel.2provided by ZNC
Official Full Name
carboxyl ester lipase, tandem duplicate 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-061110-10
See related
Ensembl:ENSDARG00000029822 AllianceGenome:ZFIN:ZDB-GENE-061110-10
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
cell; celip; basal.2; zgc:112377; zgc:153861
Summary
Is expressed in brain; heart; liver; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in lipomatosis; maturity-onset diabetes of the young type 8; type 1 diabetes mellitus; and type 2 diabetes mellitus. Orthologous to human CEL (carboxyl ester lipase). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
human mouse all
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Genomic context

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See cel.2 in Genome Data Viewer
Location:
chromosome: 21
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (11385024..11393994)
105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (11292405..11318735)

Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene zgc:162472 Neighboring gene general transcription factor IIIC, polypeptide 5 Neighboring gene carboxyl ester lipase, tandem duplicate 1 Neighboring gene zgc:92275

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Molecular cloning and characterization of an atypical butyrylcholinesterase-like protein in zebrafish. Tan KS, et al. Comp Biochem Physiol B Biochem Mol Biol, 2021 Aug-Sep. PMID 33662568
  2. Carboxyl ester lipase is highly conserved in utilizing maternal supplied lipids during early development of zebrafish and human. Qiu Y, et al. Biochim Biophys Acta Mol Cell Biol Lipids, 2020 Jun. PMID 32061751
  3. Zebrafish acetylcholinesterase is encoded by a single gene localized on linkage group 7. Gene structure and polymorphism; molecular forms and expression pattern during development. Bertrand C, et al. J Biol Chem, 2001 Jan 5. PMID 11016933
  4. Transcriptomics and Phenotypic Analysis of gpr56 Knockout in Zebrafish. Sun L, et al. Int J Mol Sci, 2023 Apr 23. PMID 37175447, Free PMC Article
  5. Systems pharmacology of adiposity reveals inhibition of EP300 as a common therapeutic mechanism of caloric restriction and resveratrol for obesity. Nishimura Y, et al. Front Pharmacol, 2015. PMID 26441656, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC112377

General protein information

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Preferred Names
bile salt-activated lipase
Names
carboxyl ester lipase, like
danio-celip
NP_001020344.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025173.2 → NP_001020344.2  bile salt-activated lipase precursor

    Status: VALIDATED

    Source sequence(s)
    BX005379, FP015918
    UniProtKB/TrEMBL
    A0A8M9PQY7
    Related
    ENSDARP00000040597.5, ENSDART00000040598.6
    Conserved Domains (1) summary
    pfam00135
    Location:26 → 539
    COesterase; Carboxylesterase family

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007132.7 Reference GRCz11 Primary Assembly

    Range
    11385024..11393994
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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