Klk11 kallikrein related-peptidase 11 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Klk11provided by MGI
Official Full Name: kallikrein related-peptidase 11provided by MGI
Primary source: MGI:MGI:1929977
See related: Ensembl:ENSMUSG00000067616 AllianceGenome:MGI:1929977
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: TLSP; Prss20; 2310015I08Rik
Summary: This gene encodes a member of the kallikrein subfamily of serine proteases that are involved in diverse physiological functions such as skin desquamation, tooth enamel formation, seminal liquefaction, synaptic neural plasticity and brain function. The encoded preproprotein undergoes proteolytic cleavage of the activation peptide to generate the functional enzyme. This gene is located in a cluster of several related kallikrein genes on chromosome 7. [provided by RefSeq, May 2016]
Expression: Biased expression in stomach adult (RPKM 11.7), lung adult (RPKM 4.1) and 3 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 B3; 7 28.26 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (43424041..43428687)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (43774617..43779263)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variants in KLK11, affecting signal peptide cleavage of kallikrein-related peptidase 11, cause an autosomal-dominant cornification disorder.
Title: Variants in KLK11, affecting signal peptide cleavage of kallikrein-related peptidase 11, cause an autosomal-dominant cornification disorder.
KLK11 promotes the activation of mTOR and protein synthesis to facilitate cardiac hypertrophy.
Title: KLK11 promotes the activation of mTOR and protein synthesis to facilitate cardiac hypertrophy.
Together, our results suggest that KLF4 regulates asthma development in a TSLP- and fibrocyte-dependent manner.
Title: Deficiency of KLF4 compromises the lung function in an acute mouse model of allergic asthma.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3) 1 citation
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables serine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in protein maturation	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
is_active_in secretory granule	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: kallikrein-11

Names: hippostasin; serine protease 20

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001177373.1 → NP_001170844.1 kallikrein-11 isoform 1 preproprotein

See identical proteins and their annotated locations for NP_001170844.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AB016226, AK009360

Consensus CDS

CCDS52227.1

UniProtKB/Swiss-Prot

Q9QYN3, Q9QYN4

UniProtKB/TrEMBL

A0A0B6VLT0

Related

ENSMUSP00000079101.6, ENSMUST00000080211.12

Conserved Domains (2) summary

smart00020
Location:47 → 269

Tryp_SPc; Trypsin-like serine protease

cd00190
Location:48 → 272

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
NM_019974.2 → NP_064358.1 kallikrein-11 isoform 2

See identical proteins and their annotated locations for NP_064358.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) represents use of an alternate promoter and 5' UTR and uses a downstream start codon, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1.

Source sequence(s)

AB016226, AC151989

Consensus CDS

CCDS39935.1

UniProtKB/TrEMBL

A0A1R3UCI4

Related

ENSMUSP00000132721.2, ENSMUST00000171458.2

Conserved Domains (1) summary

smart00020
Location:20 → 242

Tryp_SPc; Trypsin-like serine protease

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

43424041..43428687

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006541006.5 → XP_006541069.1 kallikrein-11 isoform X2

Conserved Domains (1) summary

smart00020
Location:3 → 156

Tryp_SPc; Trypsin-like serine protease
XM_017322379.2 → XP_017177868.2 kallikrein-11 isoform X1

UniProtKB/TrEMBL

A7E201

Conserved Domains (1) summary

cd00190
Location:7 → 185

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...