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slc38a2 solute carrier family 38 member 2 [ Danio rerio (zebrafish) ]

Gene ID: 566537, updated on 4-Jan-2025

Summary

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Official Symbol
slc38a2provided by ZNC
Official Full Name
solute carrier family 38 member 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-9659
See related
Ensembl:ENSDARG00000045886 AllianceGenome:ZFIN:ZDB-GENE-030131-9659
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
cb115; sb:cb115; wu:fj34c01; si:ch211-132p20.4
Summary
Predicted to enable amino acid transmembrane transporter activity. Predicted to be involved in amino acid import; neutral amino acid transport; and regulation of glutamate secretion, neurotransmission. Predicted to act upstream of or within sodium ion transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in lens; notochord; and solid lens vesicle. Orthologous to human SLC38A2 (solute carrier family 38 member 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See slc38a2 in Genome Data Viewer
Location:
chromosome: 4
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 4 NC_007115.7 (1600300..1617897)
105 previous assembly GRCz10 (GCF_000002035.5) 4 NC_007115.6 (1728543..1768584)

Chromosome 4 - NC_007115.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 38 member 4 Neighboring gene uncharacterized LOC110439353 Neighboring gene SR-related CTD-associated factor 11 Neighboring gene AT-rich interactive domain 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Crystal structure of arginine-bound lysosomal transporter SLC38A9 in the cytosol-open state. Lei HT, et al. Nat Struct Mol Biol, 2018 Jun. PMID 29872228, Free PMC Article
  2. QDPR homologues in Danio rerio regulate melanin synthesis, early gliogenesis, and glutamine homeostasis. Breuer M, et al. PLoS One, 2019. PMID 30995231, Free PMC Article
  3. Solute carriers (SLCs) identified and characterized from kidney transcriptome of golden mahseer (Tor putitora) (Fam: Cyprinidae). Barat A, et al. Comp Biochem Physiol B Biochem Mol Biol, 2016 Oct. PMID 27287540
  4. Expression and regulation of drug transporters in vertebrate neutrophils. Foulkes MJ, et al. Sci Rep, 2017 Jul 10. PMID 28694436, Free PMC Article
  5. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables L-glutamine transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables L-glutamine transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables acidic amino acid transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables alanine:sodium symporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables amino acid:sodium symporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables neutral L-amino acid transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables neutral L-amino acid:sodium symporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables proline:sodium symporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables symporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in L-glutamine import across plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in L-proline import across plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in L-serine import across plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in alanine transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in amino acid import ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in amino acid transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within amino acid transport IEA
Inferred from Electronic Annotation
more info
  
involved_in amino acid transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in glutamine transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in neutral amino acid transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in proline transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of glutamate secretion, neurotransmission ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within sodium ion transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
sodium-coupled neutral amino acid symporter 2
Names
amino acid transporter A2
sodium-coupled neutral amino acid transporter 2
solute carrier family 38, member 2 like
system A amino acid transporter 2
system A transporter 1
system N amino acid transporter 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001045104.1 → NP_001038569.1  sodium-coupled neutral amino acid symporter 2

    See identical proteins and their annotated locations for NP_001038569.1

    Status: PROVISIONAL

    Source sequence(s)
    AL929171
    UniProtKB/Swiss-Prot
    Q5SPB1
    Related
    ENSDARP00000118404.2, ENSDART00000146779.3
    Conserved Domains (2) summary
    COG0814
    Location:70 → 479
    SdaC; Amino acid permease [Amino acid transport and metabolism]
    cl00456
    Location:72 → 488
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007115.7 Reference GRCz11 Primary Assembly

    Range
    1600300..1617897
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5SPB1.1 GenPept UniProtKB/Swiss-Prot:Q5SPB1

Gene LinkOut

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