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serping1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1 [ Danio rerio (zebrafish) ]

Gene ID: 567801, updated on 4-Jan-2025

Summary

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Official Symbol
serping1provided by ZNC
Official Full Name
serpin peptidase inhibitor, clade G (C1 inhibitor), member 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-1262
See related
Ensembl:ENSDARG00000058053 AllianceGenome:ZFIN:ZDB-GENE-030131-1262
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
C1IN; im:7159527; wu:fb60c09; wu:fb62a08; wu:fb64f02; si:dkeyp-110g5.2
Summary
Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be located in extracellular space and plasma membrane. Is expressed in liver. Human ortholog(s) of this gene implicated in several diseases, including COVID-19; angioedema (multiple); cerebral infarction; pancreatitis; and toxic shock syndrome. Orthologous to human SERPING1 (serpin family G member 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
human mouse all
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Genomic context

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See serping1 in Genome Data Viewer
Location:
chromosome: 8
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (13960655..13972626, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (13922479..13934944, complement)

Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene calcium binding protein 4 Neighboring gene double C2-like domains, gamma Neighboring gene si:dkeyp-110g5.4 Neighboring gene insulin-like growth factor 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Molecular phylogeny of C1 inhibitor depicts two immunoglobulin-like domains fusion in fishes and ray-finned fishes specific intron insertion after separation from zebrafish. Kumar A, et al. Biochem Biophys Res Commun, 2014 Jul 18. PMID 24878530
  2. Cloning of six serpin genes and their responses to GCRV infection in grass carp (Ctenopharyngodon idella). Chen L, et al. Fish Shellfish Immunol, 2019 Mar. PMID 30439497
  3. Inhibition of SERPINe1 reduces rhabdoviral infections in zebrafish. Estepa A, et al. Fish Shellfish Immunol, 2015 Nov. PMID 26363229, Free PMC Article
  4. Zebrafish models of alx-linked frontonasal dysplasia reveal a role for Alx1 and Alx3 in the anterior segment and vasculature of the developing eye. Yoon B, et al. Biol Open, 2022 May 15. PMID 35142342, Free PMC Article
  5. Regulation of spermatogonial development by Fsh: The complementary roles of locally produced Igf and Wnt signaling molecules in adult zebrafish testis. Safian D, et al. Gen Comp Endocrinol, 2019 Dec 1. PMID 31415728

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables serine-type endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
plasma protease C1 inhibitor
Names
C1 inhibitor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001123285.1 → NP_001116757.1  plasma protease C1 inhibitor precursor

    See identical proteins and their annotated locations for NP_001116757.1

    Status: PROVISIONAL

    Source sequence(s)
    CT025854
    UniProtKB/TrEMBL
    A0A8M1NGQ6, A0A8M2BED5, B0V2R7
    Related
    ENSDARP00000119903.1, ENSDART00000144296.2
    Conserved Domains (4) summary
    smart00410
    Location:18 → 101
    IG_like; Immunoglobulin like
    pfam13895
    Location:25 → 101
    Ig_2; Immunoglobulin domain
    cl00137
    Location:247 → 601
    SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...
    cl11960
    Location:112 → 205
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007119.7 Reference GRCz11 Primary Assembly

    Range
    13960655..13972626 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005166883.5 → XP_005166940.4  plasma protease C1 inhibitor isoform X1

    UniProtKB/TrEMBL
    A0A8M1NGQ6, A0A8M2BED5, B0V2R7
Nucleotide Protein
Heading Accession and Version

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