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maptb microtubule-associated protein tau b [ Danio rerio (zebrafish) ]

Gene ID: 567833, updated on 4-Jan-2025

Summary

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Official Symbol
maptbprovided by ZNC
Official Full Name
microtubule-associated protein tau bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-081027-2
See related
Ensembl:ENSDARG00000087616 AllianceGenome:ZFIN:ZDB-GENE-081027-2
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary
Predicted to enable microtubule binding activity. Predicted to be located in cytoplasm and microtubule. Is expressed in nervous system; shield; spinal cord neural tube; and trigeminal placode. Human ortholog(s) of this gene implicated in dementia (multiple); neurodegenerative disease (multiple); progressive supranuclear palsy; and temporal lobe epilepsy. Orthologous to human MAPT (microtubule associated protein tau). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See maptb in Genome Data Viewer
Location:
chromosome: 3
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (22158021..22216455, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (22027473..22085882, complement)

Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene cell division cycle 27 Neighboring gene KAT8 regulatory NSL complex subunit 1b Neighboring gene myosin, light chain 4, alkali; atrial, embryonic Neighboring gene sodium channel, voltage-gated, type IV, alpha, b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Complex splicing and neural expression of duplicated tau genes in zebrafish embryos. Chen M, et al. J Alzheimers Dis, 2009. PMID 19584432
  2. Gender-Specific Expression of Ubiquitin-Specific Peptidase 9 Modulates Tau Expression and Phosphorylation: Possible Implications for Tauopathies. Köglsberger S, et al. Mol Neurobiol, 2017 Dec. PMID 27878758, Free PMC Article
  3. Hypoxia alters expression of zebrafish microtubule-associated protein tau (mapta, maptb) gene transcripts. Moussavi Nik SH, et al. BMC Res Notes, 2014 Oct 31. PMID 25359609, Free PMC Article
  4. Garcinol pacifies acrylamide induced cognitive impairments, neuroinflammation and neuronal apoptosis by modulating GSK signaling and activation of pCREB by regulating cathepsin B in the brain of zebrafish larvae. Sharma C, et al. Food Chem Toxicol, 2020 Apr. PMID 32156567
  5. Folate deprivation induced neuroinflammation impairs cognition. Shaikh A, et al. Neurosci Lett, 2023 Jun 11. PMID 37086862

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Multiple signaling factors and drugs alleviate neuronal death induced by expression of human and zebrafish tau proteins in vivo.
    Title: Multiple signaling factors and drugs alleviate neuronal death induced by expression of human and zebrafish tau proteins in vivo.
  2. Hypoxia can alter splicing of zebrafish MAPT co-orthologues promoting formation of longer transcripts and possibly generating Mapt proteins more prone to hyperphosphorylation.
    Title: Hypoxia alters expression of zebrafish microtubule-associated protein tau (mapta, maptb) gene transcripts.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables microtubule binding IEA
Inferred from Electronic Annotation
more info
  
enables tubulin binding IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
microtubule-associated protein tau

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007114.7 Reference GRCz11 Primary Assembly

    Range
    22158021..22216455 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068218902.1 → XP_068075003.1  microtubule-associated protein tau isoform X5

    UniProtKB/TrEMBL
    A0A8M2BIX4

  2. XM_068218901.1 → XP_068075002.1  microtubule-associated protein tau isoform X4

    UniProtKB/TrEMBL
    A0A8M9Q3A3

  3. XM_068218898.1 → XP_068074999.1  microtubule-associated protein tau isoform X2

    UniProtKB/TrEMBL
    A0A8M9Q3A3

  4. XM_021473452.2 → XP_021329127.1  microtubule-associated protein tau isoform X6

    UniProtKB/TrEMBL
    A0A8M9PDF7, A0A8M9Q3A3
    Conserved Domains (2) summary
    pfam00418
    Location:619 → 648
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    cl26464
    Location:266 → 581
    Atrophin-1; Atrophin-1 family

  5. XM_068218896.1 → XP_068074997.1  microtubule-associated protein tau isoform X1

    UniProtKB/TrEMBL
    A0A8M9Q3A3

  6. XM_068218899.1 → XP_068075000.1  microtubule-associated protein tau isoform X3

    UniProtKB/TrEMBL
    A0A8M9Q7D2
    Related
    ENSDARP00000106770.2, ENSDART00000130546.3

  7. XM_068218897.1 → XP_068074998.1  microtubule-associated protein tau isoform X1

    UniProtKB/TrEMBL
    A0A8M9Q3A3
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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