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Cacna1i calcium voltage-gated channel subunit alpha1 I [ Rattus norvegicus (Norway rat) ]

Gene ID: 56827, updated on 4-Jan-2025

Summary

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Official Symbol
Cacna1iprovided by RGD
Official Full Name
calcium voltage-gated channel subunit alpha1 Iprovided by RGD
Primary source
RGD:68944
See related
EnsemblRapid:ENSRNOG00000060407 AllianceGenome:RGD:68944
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables low voltage-gated calcium channel activity. Involved in calcium ion import and calcium ion transport into cytosol. Acts upstream of or within calcium ion transport and regulation of membrane potential. Predicted to be part of voltage-gated sodium channel complex. Predicted to be active in neuron projection. Biomarker of sciatic neuropathy. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to human CACNA1I (calcium voltage-gated channel subunit alpha1 I). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Restricted expression toward (RPKM 56.3) See more
Orthologs
human mouse all
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Genomic context

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See Cacna1i in Genome Data Viewer
Location:
7q34
Exon count:
37
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (113716266..113827670)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (111835996..111947418)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (121521787..121619300)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein S19 binding protein 1 Neighboring gene activating transcription factor 4 Neighboring gene uncharacterized LOC134479941 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene ENTH domain containing 1 Neighboring gene BAF nuclear assembly factor 1, pseudogene 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. In vitro neurotoxicity by ropivacaine is reduced by silencing Cav3.3 T-type calcium subunits in neonatal rat sensory neurons. Wen X, et al. Artif Cells Nanomed Biotechnol, 2018 Dec. PMID 28974111
  2. Identification of T-type alpha1H Ca2+ channels (Ca(v)3.2) in major pelvic ganglion neurons. Lee JH, et al. J Neurophysiol, 2002 Jun. PMID 12037187
  3. Methamphetamine blunts Ca(2+) currents and excitatory synaptic transmission through D1/5 receptor-mediated mechanisms in the mouse medial prefrontal cortex. González B, et al. Addict Biol, 2016 May. PMID 25871318, Free PMC Article
  4. Alternative splicing of the rat Ca(v)3.3 T-type calcium channel gene produces variants with distinct functional properties(1). Murbartián J, et al. FEBS Lett, 2002 Sep 25. PMID 12297319
  5. Mechanisms underlying afterload-induced exacerbation of myocardial infarct size: role of T-type Ca2+ channel. Mozaffari MS, et al. Hypertension, 2006 May. PMID 16505194

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A novel phospho-modulatory mechanism contributes to the calcium-dependent regulation of T-type Ca(2+) channels.
    Title: A novel phospho-modulatory mechanism contributes to the calcium-dependent regulation of T-type Ca(2+) channels.
  2. Cav3.3 overexpression aggravated DRG injury induced by ropivacaine hydrochloride and inhibition of Cav3.3 expression improved the cell damages. Cav3.3 can regulate CaMKIIgamma mRNA and protein expression.
    Title: In vitro neurotoxicity by ropivacaine is reduced by silencing Cav3.3 T-type calcium subunits in neonatal rat sensory neurons.
  3. Extracellular pressure increases [Ca(2+)]i via Cav3.3, driving a PKC-beta- IKK- IkB-NF-kB pathway that stimulates cancer cell proliferation
    Title: Increased extracellular pressure stimulates tumor proliferation by a mechanosensitive calcium channel and PKC-β.
  4. Results suggest that T-type Ca channels Cav3.1, Cav3.2 and Cav3.3 are potential therapeutic targets for the treatment of spinal nerve ligation-induced neuropathic pain.
    Title: Upregulation of T-type Ca2+ channels in primary sensory neurons in spinal nerve injury.
  5. Important link between pressure-mediated exacerbation of infarct size and T-type Ca2+ channel activity.
    Title: Mechanisms underlying afterload-induced exacerbation of myocardial infarct size: role of T-type Ca2+ channel.
  6. T-type alpha1H Ca2+ channels (Ca(v)3.2) in major pelvic ganglion neurons.
    Title: Identification of T-type alpha1H Ca2+ channels (Ca(v)3.2) in major pelvic ganglion neurons.
  7. T-type Ca2+ channels appear to be essential for the initiation of the spontaneous activity in mammalian bipolar cells.
    Title: Spontaneous regenerative activity in mammalian retinal bipolar cells: roles of multiple subtypes of voltage-dependent Ca2+ channels.
  8. alternative splicing produces channels with distinct properties
    Title: Alternative splicing of the rat Ca(v)3.3 T-type calcium channel gene produces variants with distinct functional properties(1).
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables low voltage-gated calcium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables low voltage-gated calcium channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables voltage-gated calcium channel activity IEA
Inferred from Electronic Annotation
more info
  
enables voltage-gated calcium channel activity ISO
Inferred from Sequence Orthology
more info
  
enables voltage-gated sodium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in calcium ion import IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in calcium ion import IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in calcium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within calcium ion transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in calcium ion transport into cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in membrane depolarization during action potential IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neuronal action potential IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within neuronal action potential ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of calcium ion-dependent exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of membrane potential IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in sleep IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within sleep ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of voltage-gated calcium channel complex IC
Inferred by Curator
more info
 PubMed 
part_of voltage-gated calcium channel complex IEA
Inferred from Electronic Annotation
more info
  
part_of voltage-gated sodium channel complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
voltage-dependent T-type calcium channel subunit alpha-1I
Names
caVT.3
calcium channel, voltage-dependent, T type, alpha 1I subunit
calcium channel, voltage-dependent, alpha 1I subunit
hypothetical gene supported by NM_020084
low voltage-activated T-type calcium channel alpha-1 subunit (CACNA1I)
voltage-dependent calcium channel
voltage-gated calcium channel subunit alpha Cav3.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020084.4 → NP_064469.4  voltage-dependent T-type calcium channel subunit alpha-1I

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/TrEMBL
    A0A8I5ZQK3, A0A8I6APG9
    Related
    ENSRNOP00000080577.2, ENSRNOT00000092608.3
    Conserved Domains (2) summary
    PHA03307
    Location:1840 → 2195
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam00520
    Location:597 → 824
    Ion_trans; Ion transport protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    113716266..113827670
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063264170.1 → XP_063120240.1  voltage-dependent T-type calcium channel subunit alpha-1I isoform X4

    UniProtKB/TrEMBL
    A0A8I6APG9

  2. XM_063264168.1 → XP_063120238.1  voltage-dependent T-type calcium channel subunit alpha-1I isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZQK3, A0A8I6APG9
    Related
    ENSRNOP00000095801.1, ENSRNOT00000084352.3

  3. XM_063264167.1 → XP_063120237.1  voltage-dependent T-type calcium channel subunit alpha-1I isoform X1

    UniProtKB/TrEMBL
    A0A8I6APG9

  4. XM_063264169.1 → XP_063120239.1  voltage-dependent T-type calcium channel subunit alpha-1I isoform X3

    UniProtKB/TrEMBL
    A0A8I6APG9
    Related
    ENSRNOP00000104426.1, ENSRNOT00000144089.1
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Z0Y8.3 GenPept UniProtKB/Swiss-Prot:Q9Z0Y8

Gene LinkOut

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