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LGALS14 galectin 14 [ Homo sapiens (human) ]

Gene ID: 56891, updated on 27-Nov-2024

Summary

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Official Symbol
LGALS14provided by HGNC
Official Full Name
galectin 14provided by HGNC
Primary source
HGNC:HGNC:30054
See related
Ensembl:ENSG00000006659 MIM:607260; AllianceGenome:HGNC:30054
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CLC2; PPL13
Summary
This gene is predominantly expressed in placenta. The encoded protein belongs to the galectin (galaptin/S-lectin) family. The members of galectin family contain one or two carbohydrate recognition domains, which can bind beta-galactoside. Two alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward placenta (RPKM 25.5) See more
Orthologs
all
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Genomic context

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See LGALS14 in Genome Data Viewer
Location:
19q13.2
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (39704481..39709444)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (42508740..42513703)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (40195121..40200084)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene galectin 14 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14626 Neighboring gene ribosomal protein S29 pseudogene 27 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14627 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14628 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14629 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14630 Neighboring gene Charcot-Leyden crystal galectin Neighboring gene leucine twenty homeobox

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. [siRNA-mediated silencing of ClC-2 gene inhibits proliferation of human U-87 glioma cells]. Yang XY, et al. Ai Zheng, 2006 Jul. PMID 16831268
  2. Structure-function studies of galectin-14, an important effector molecule in embryology. Si Y, et al. FEBS J, 2021 Feb. PMID 32525264
  3. Cloning and expression of a novel human galectin cDNA, predominantly expressed in placenta(1). Yang QS, et al. Biochim Biophys Acta, 2002 Apr 12. PMID 11997112
  4. A primate subfamily of galectins expressed at the maternal-fetal interface that promote immune cell death. Than NG, et al. Proc Natl Acad Sci U S A, 2009 Jun 16. PMID 19497882, Free PMC Article
  5. Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study. Shiffman D, et al. Arterioscler Thromb Vasc Biol, 2008 Jan. PMID 17975119, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Structure-function studies of galectin-14, an important effector molecule in embryology.
    Title: Structure-function studies of galectin-14, an important effector molecule in embryology.
  2. CIC-2 siRNA could inhibit the cell proliferation of a human glioma cell line U-87.
    Title: [siRNA-mediated silencing of ClC-2 gene inhibits proliferation of human U-87 glioma cells].
  3. Observational study of gene-disease association. (HuGE Navigator)
    Title: Gene variants associated with ischemic stroke: the cardiovascular health study.
  4. cloning and expression in placenta - base sequence and amino acid sequences are given
    Title: Cloning and expression of a novel human galectin cDNA, predominantly expressed in placenta(1).
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC22235

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables carbohydrate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  

General protein information

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Preferred Names
placental protein 13-like
Names
Charcot-Leyden crystal protein 2
gal-14
lectin, galactoside-binding, soluble, 14
placental protein 13-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020129.3 → NP_064514.1  placental protein 13-like isoform 1

    See identical proteins and their annotated locations for NP_064514.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) appears to be the major transcript. It lacks an exon compared to variant 2. The resulting isoform (1) has a distinct and shorter N-terminus, as compared to isoform 2.
    Source sequence(s)
    AF267852
    Consensus CDS
    CCDS46073.1
    UniProtKB/Swiss-Prot
    A8MPV8, B2R530, C5HZ19, Q7Z4X8, Q8TCE9, Q96KD4, Q96KD5, Q96KD6, Q9NR03
    Related
    ENSP00000375905.2, ENST00000392052.8
    Conserved Domains (1) summary
    pfam00337
    Location:5 → 137
    Gal-bind_lectin; Galactoside-binding lectin

  2. NM_203471.2 → NP_982297.1  placental protein 13-like isoform 2

    See identical proteins and their annotated locations for NP_982297.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) encodes the longer isoform (2).
    Source sequence(s)
    AI167958, BC022257, BG434228
    Consensus CDS
    CCDS12542.1
    UniProtKB/Swiss-Prot
    Q8TCE9
    Related
    ENSP00000353893.2, ENST00000360675.7
    Conserved Domains (1) summary
    pfam00337
    Location:37 → 166
    Gal-bind_lectin; Galactoside-binding lectin

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    39704481..39709444
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    42508740..42513703
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8TCE9.2 GenPept UniProtKB/Swiss-Prot:Q8TCE9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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