U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

flvcr2b FLVCR choline and putative heme transporter 2b [ Danio rerio (zebrafish) ]

Gene ID: 569329, updated on 4-Jan-2025

Summary

Go to the top of the page Help
Official Symbol
flvcr2bprovided by ZNC
Official Full Name
FLVCR choline and putative heme transporter 2bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-041210-312
See related
Ensembl:ENSDARG00000031506 AllianceGenome:ZFIN:ZDB-GENE-041210-312
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fc07b07; wu:fc07b07; si:ch211-119b12.6
Summary
Predicted to enable ethanolamine transmembrane transporter activity; heme binding activity; and heme transmembrane transporter activity. Predicted to be involved in heme export and transport across blood-brain barrier. Predicted to act upstream of or within transmembrane transport. Predicted to be located in endoplasmic reticulum membrane and mitochondrial membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in proliferative vasculopathy and hydranencephaly-hydrocephaly syndrome. Orthologous to human FLVCR2 (FLVCR choline and putative heme transporter 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See flvcr2b in Genome Data Viewer
Location:
chromosome: 20
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (46311440..46349064)
105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (46407412..46445332)

Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene trace amine associated receptor 14d Neighboring gene trace amine associated receptor 14b Neighboring gene BCL2 modifying factor 2 Neighboring gene adhesion G protein-coupled receptor G11

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ethanolamine transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables heme binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables heme transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in heme export IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in transport across blood-brain barrier ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

Go to the top of the page Help
Preferred Names
choline/ethanolamine transporter flvcr2b; heme transporter FLVCR2
Names
FLVCR heme transporter 2b
feline leukemia virus subgroup C cellular receptor family, member 2b
feline leukemia virus subgroup C receptor-related protein 2 homolog B
flvsr2a
heme transporter flvcr2b
major facilitator superfamily domain containing 7C-b

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007131.7 Reference GRCz11 Primary Assembly

    Range
    46311440..46349064
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_003200755.6 → XP_003200803.1  heme transporter FLVCR2 isoform X1

    UniProtKB/TrEMBL
    A0AAR9KR84
    Related
    ENSDARP00000038667.5, ENSDART00000038696.8
    Conserved Domains (2) summary
    cd06174
    Location:60 → 458
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    pfam07690
    Location:60 → 424
    MFS_1; Major Facilitator Superfamily

  2. XM_005160868.5 → XP_005160925.1  heme transporter FLVCR2 isoform X2

    UniProtKB/TrEMBL
    A0AAR9Y6Z6
    Related
    ENSDARP00000145286.1, ENSDART00000184743.1
    Conserved Domains (2) summary
    cd06174
    Location:60 → 458
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    pfam07690
    Location:60 → 424
    MFS_1; Major Facilitator Superfamily

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018395077.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    47883..81755
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021473380.2 → XP_021329055.1  heme transporter FLVCR2 isoform X1

    UniProtKB/TrEMBL
    A0AAS8BI50
    Conserved Domains (1) summary
    cd06174
    Location:60 → 458
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

  2. XM_021473381.2 → XP_021329056.1  heme transporter FLVCR2 isoform X2

    UniProtKB/Swiss-Prot
    A0A8M1RMV1, A0A8M2B829, A0A8M9Q308, A0A8M9Q757, E9QH04
    Conserved Domains (1) summary
    cd06174
    Location:60 → 458
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A8M9Q308.1 GenPept UniProtKB/Swiss-Prot:A0A8M9Q308

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools