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dcc DCC netrin 1 receptor [ Danio rerio (zebrafish) ]

Gene ID: 569360, updated on 4-Jan-2025

Summary

Official Symbol
dccprovided by ZNC
Official Full Name
DCC netrin 1 receptorprovided by ZNC
Primary source
ZFIN:ZDB-GENE-011101-2
See related
Ensembl:ENSDARG00000104282 AllianceGenome:ZFIN:ZDB-GENE-011101-2
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zdcc
Summary
Enables netrin receptor activity involved in chemoattraction. Acts upstream of or within with a positive effect on commissural neuron axon guidance. Acts upstream of or within neuron differentiation and regulation of axon extension. Predicted to be located in membrane. Predicted to be active in cell surface and plasma membrane. Is expressed in several structures, including brain; neural tube; pleuroperitoneal region; posterior neural rod; and primary motor neurons. Human ortholog(s) of this gene implicated in colorectal cancer; congenital mirror movement disorder; and esophagus squamous cell carcinoma. Orthologous to human DCC (DCC netrin 1 receptor). [provided by Alliance of Genome Resources, Jan 2025]
Annotation information
Annotation category: partial on reference assembly
Orthologs
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Genomic context

See dcc in Genome Data Viewer
Location:
chromosome: 5
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (31747..201600, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (3336..102122, complement)

Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene TraB domain containing 2A Neighboring gene hook microtubule-tethering protein 3

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General gene information

Markers

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables netrin receptor activity involved in chemoattraction IGI
Inferred from Genetic Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within anterior commissure morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within anterior/posterior axon guidance IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within axon extension involved in axon guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within axon guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within axon regeneration IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
 
involved_in cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within central nervous system projection neuron axonogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within_positive_effect commissural neuron axon guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within dendrite development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within neuron fate specification IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neuron migration IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within olfactory bulb axon guidance IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within olfactory bulb axon guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of axon extension IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within regulation of axon extension IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
netrin receptor DCC
Names
deleted in colorectal cancer
deleted in colorectal carcinoma
spaced out
spo

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001034985.1NP_001030157.1  netrin receptor DCC precursor

    See identical proteins and their annotated locations for NP_001030157.1

    Status: PROVISIONAL

    Source sequence(s)
    AY956314
    UniProtKB/TrEMBL
    Q49BB0
    Related
    ENSDARP00000137236.2, ENSDART00000158495.2
    Conserved Domains (5) summary
    smart00410
    Location:142226
    IG_like; Immunoglobulin like
    cd00063
    Location:425517
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:327412
    I-set; Immunoglobulin I-set domain
    pfam06583
    Location:11251419
    Neogenin_C; Neogenin C-terminus
    cl11960
    Location:36131
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007116.7 Reference GRCz11 Primary Assembly

    Range
    31747..201600 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)