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PMEPA1 prostate transmembrane protein, androgen induced 1 [ Homo sapiens (human) ]

Gene ID: 56937, updated on 27-Nov-2024

Summary

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Official Symbol
PMEPA1provided by HGNC
Official Full Name
prostate transmembrane protein, androgen induced 1provided by HGNC
Primary source
HGNC:HGNC:14107
See related
Ensembl:ENSG00000124225 MIM:606564; AllianceGenome:HGNC:14107
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
STAG1; TMEPAI
Summary
This gene encodes a transmembrane protein that contains a Smad interacting motif (SIM). Expression of this gene is induced by androgens and transforming growth factor beta, and the encoded protein suppresses the androgen receptor and transforming growth factor beta signaling pathways though interactions with Smad proteins. Overexpression of this gene may play a role in multiple types of cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
Expression
Broad expression in prostate (RPKM 54.2), fat (RPKM 28.9) and 20 other tissues See more
Orthologs
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Genomic context

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See PMEPA1 in Genome Data Viewer
Location:
20q13.31
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (57648396..57711472, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (59426291..59489466, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (56223452..56286528, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:56143743-56144243 Neighboring gene Sharpr-MPRA regulatory region 2062 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:56165049-56165804 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13064 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:56172128-56172301 Neighboring gene phosphoenolpyruvate carboxykinase 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:56193035-56193894 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18165 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18166 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18167 Neighboring gene Z-DNA binding protein 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13065 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:56229759-56230358 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:56230359-56230956 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18168 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:56236773-56237645 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:56238905-56239419 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:56241925-56242541 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:56251833-56252416 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:56253071-56253587 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:56253588-56254103 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:56254668-56255192 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:56255193-56255716 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18170 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18171 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18172 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:56257022-56257522 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:56267863-56268682 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:56271371-56271903 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr20:56272784-56273983 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:56279768-56280362 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:56283453-56284064 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13066 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13067 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:56287125-56287736 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:56290116-56290644 Neighboring gene uncharacterized LOC105372692 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:56299854-56300354 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:56300355-56300855 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:56319851-56320352 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:56320353-56320852 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:56322729-56323588 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:56323589-56324446 Neighboring gene NF-kappaB interacting lncRNA Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:56346807-56347450 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:56347451-56348092 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:56358085-56358678 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:56369354-56369854 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:56410252-56410913 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:56410914-56411574 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:56474981-56475610 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:56475611-56476238 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:56496341-56496840 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:56527975-56528475 Neighboring gene uncharacterized LOC105372693

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Cooperative induction of transmembrane prostate androgen induced protein TMEPAI/PMEPA1 by transforming growth factor-β and epidermal growth factor signaling. Azami S, et al. Biochem Biophys Res Commun, 2015 Jan 9. PMID 25482449
  2. TMEPAI/PMEPA1 inhibits Wnt signaling by regulating β-catenin stability and nuclear accumulation in triple negative breast cancer cells. Amalia R, et al. Cell Signal, 2019 Jul. PMID 30890370
  3. PMEPA1 induces EMT via a non-canonical TGF-β signalling in colorectal cancer. Zhang L, et al. J Cell Mol Med, 2019 May. PMID 30887697, Free PMC Article
  4. PMEPA1/TMEPAI knockout impairs tumour growth and lung metastasis in MDA-MB-231 cells without changing monolayer culture cell growth. Abdelaziz M, et al. J Biochem, 2019 May 1. PMID 30873542
  5. 2-(2-nitrobenzylidene) indolin-3-one compound inhibits transmembrane prostate androgen-induced protein (TMEPAI) expression and cancer cell proliferation. Li Y, et al. Cell Prolif, 2018 Oct. PMID 30069967, Free PMC Article

See all (67) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CSDE1 attenuates microRNA-mediated silencing of PMEPA1 in melanoma.
    Title: CSDE1 attenuates microRNA-mediated silencing of PMEPA1 in melanoma.
  2. METTL16 suppressed the proliferation and cisplatin-chemoresistance of bladder cancer by degrading PMEPA1 mRNA in a m6A manner through autophagy pathway.
    Title: METTL16 suppressed the proliferation and cisplatin-chemoresistance of bladder cancer by degrading PMEPA1 mRNA in a m6A manner through autophagy pathway.
  3. Exploring the role of PMEPA1 in gastric cancer.
    Title: Exploring the role of PMEPA1 in gastric cancer.
  4. PMEPA1 Serves as a Prognostic Biomarker and Correlates with Immune Infiltrates in Cervical Cancer.
    Title: PMEPA1 Serves as a Prognostic Biomarker and Correlates with Immune Infiltrates in Cervical Cancer.
  5. PMEPA1 facilitates non-small cell lung cancer progression via activating the JNK signaling pathway.
    Title: PMEPA1 facilitates non-small cell lung cancer progression via activating the JNK signaling pathway.
  6. PMEPA1 Is a Prognostic Biomarker That Correlates With Cell Malignancy and the Tumor Microenvironment in Bladder Cancer.
    Title: PMEPA1 Is a Prognostic Biomarker That Correlates With Cell Malignancy and the Tumor Microenvironment in Bladder Cancer.
  7. PMEPA1 Stimulates the Proliferation, Colony Formation of Pancreatic Cancer Cells via the MAPK Signaling Pathway.
    Title: PMEPA1 Stimulates the Proliferation, Colony Formation of Pancreatic Cancer Cells via the MAPK Signaling Pathway.
  8. PMEPA1 Gene Isoforms: A Potential Biomarker and Therapeutic Target in Prostate Cancer.
    Title: PMEPA1 Gene Isoforms: A Potential Biomarker and Therapeutic Target in Prostate Cancer.
  9. Linc00941 regulates esophageal squamous cell carcinoma via functioning as a competing endogenous RNA for miR-877-3p to modulate PMEPA1 expression.
    Title: Linc00941 regulates esophageal squamous cell carcinoma via functioning as a competing endogenous RNA for miR-877-3p to modulate PMEPA1 expression.
  10. Diagnostic and therapeutic values of PMEPA1 and its correlation with tumor immunity in pan-cancer.
    Title: Diagnostic and therapeutic values of PMEPA1 and its correlation with tumor immunity in pan-cancer.
Submit: New GeneRIF Correction See all GeneRIFs (38)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
EBI GWAS Catalog
Preliminary evidence of genetic determinants of adiponectin response to fenofibrate in the Genetics of Lipid Lowering Drugs and Diet Network.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of prostate transmembrane protein, androgen induced 1 (PMEPA1) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Nef nef The yeast two-hybrid screen identifies the HIV-1 Nef interacting human protein prostate transmembrane protein, androgen induced 1 (PMEPA1) in cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables R-SMAD binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables R-SMAD binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables WW domain binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein sequestering activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in androgen receptor signaling pathway NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in negative regulation of SMAD protein signal transduction IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of SMAD protein signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of transforming growth factor beta receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of transforming growth factor beta receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of transforming growth factor beta receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in early endosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in early endosome membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in early endosome membrane TAS
Traceable Author Statement
more info
  
located_in endosome membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
  
located_in membrane NAS
Non-traceable Author Statement
more info
 PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
protein TMEPAI
Names
solid tumor-associated 1 protein
solid tumor-associated gene 1
transmembrane, prostate androgen induced RNA

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_031951.1 RefSeqGene

    Range
    6522..68141
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001255976.2 → NP_001242905.1  protein TMEPAI isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (d) is shorter and has a distinct N-terminus, compared to isoform a.
    Source sequence(s)
    AF305616, AL121913, BQ008707, BU196912
    UniProtKB/TrEMBL
    Q66K30
    Related
    ENSP00000401506.1, ENST00000414037.5

  2. NM_020182.5 → NP_064567.2  protein TMEPAI isoform a

    See identical proteins and their annotated locations for NP_064567.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AF305616, AL121913, BM846677, BQ008707
    Consensus CDS
    CCDS13463.1
    UniProtKB/Swiss-Prot
    Q5TDR6, Q8NER4, Q969W9, Q96B72, Q9UJD3
    UniProtKB/TrEMBL
    Q66K30
    Related
    ENSP00000345826.3, ENST00000341744.8

  3. NM_199169.3 → NP_954638.1  protein TMEPAI isoform b

    See identical proteins and their annotated locations for NP_954638.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (b) is shorter and has a distinct N-terminus, compared to isoform a.
    Source sequence(s)
    AF224278, AF305616, AK296199, BQ008707
    Consensus CDS
    CCDS13462.1
    UniProtKB/TrEMBL
    Q5JY37, Q66K30
    Related
    ENSP00000344014.4, ENST00000347215.8

  4. NM_199170.3 → NP_954639.1  protein TMEPAI isoform c

    See identical proteins and their annotated locations for NP_954639.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream, in-frame start codon, compared to variant 1. Variants 3 and 4 encode the same isoform (c), which has a shorter N-terminus compared to isoform a.
    Source sequence(s)
    AF305616, AK296199, AY128643, BQ008707
    Consensus CDS
    CCDS13464.1
    UniProtKB/TrEMBL
    Q66K30
    Related
    ENSP00000379161.3, ENST00000395816.7
    Conserved Domains (1) summary
    cl21455
    Location:102 → 159
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  5. NM_199171.3 → NP_954640.1  protein TMEPAI isoform c

    See identical proteins and their annotated locations for NP_954640.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream, in-frame start codon, compared to variant 1. Variants 3 and 4 encode the same isoform (c), which has a shorter N-terminus compared to isoform a.
    Source sequence(s)
    AF305616, AL732104, BQ008707
    Consensus CDS
    CCDS13464.1
    UniProtKB/TrEMBL
    Q66K30
    Related
    ENSP00000265626.4, ENST00000265626.8
    Conserved Domains (1) summary
    cl21455
    Location:102 → 159
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

    Range
    57648396..57711472 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060944.1 Alternate T2T-CHM13v2.0

    Range
    59426291..59489466 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q969W9.1 GenPept UniProtKB/Swiss-Prot:Q969W9

Gene LinkOut

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