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plcb2 phospholipase C, beta 2 [ Danio rerio (zebrafish) ]

Gene ID: 569376, updated on 4-Jan-2025

Summary

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Official Symbol
plcb2provided by ZNC
Official Full Name
phospholipase C, beta 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-080419-1
See related
AllianceGenome:ZFIN:ZDB-GENE-080419-1
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary
Predicted to enable calcium ion binding activity and phosphatidylinositol phospholipase C activity. Acts upstream of or within atrioventricular canal development and determination of heart left/right asymmetry. Is expressed in digestive system; oral cavity; and taste bud. Used to study congenital heart disease. Orthologous to human PLCB2 (phospholipase C beta 2). [provided by Alliance of Genome Resources, Jan 2025]
Annotation information
Annotation category: partial on reference assembly
Orthologs
all
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Genomic context

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See plcb2 in Genome Data Viewer
Location:
chromosome: 17
Exon count:
29
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 17 NC_007128.7 (2335547..2427807, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 17 NC_007128.6 (2160719..2251777, complement)

Chromosome 17 - NC_007128.7Genomic Context describing neighboring genes Neighboring gene p21 (RAC1) activated kinase 6 Neighboring gene ankyrin repeat domain 63 Neighboring gene coiled-coil domain containing 9B Neighboring gene uncharacterized LOC137488060

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Expression of taste sentinels, T1R, T2R, and PLCβ2, on the passageway for olfactory signals in zebrafish. Birdal G, et al. Chem Senses, 2023 Jan 1. PMID 37843175
  2. Transgenic labeling of taste receptor cells in model fish under the control of the 5'-upstream region of medaka phospholipase C-beta 2 gene. Aihara Y, et al. Gene Expr Patterns, 2007 Jan. PMID 16920036
  3. Systems genetics analysis identifies calcium-signaling defects as novel cause of congenital heart disease. Izarzugaza JMG, et al. Genome Med, 2020 Aug 28. PMID 32859249, Free PMC Article
  4. Diversity in cell motility reveals the dynamic nature of the formation of zebrafish taste sensory organs. Soulika M, et al. Development, 2016 Jun 1. PMID 27122167
  5. Characterization of ligands for fish taste receptors. Oike H, et al. J Neurosci, 2007 May 23. PMID 17522303, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Expression of taste sentinels, T1R, T2R, and PLCbeta2, on the passageway for olfactory signals in zebrafish.
    Title: Expression of taste sentinels, T1R, T2R, and PLCβ2, on the passageway for olfactory signals in zebrafish.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol phospholipase C activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphoric diester hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within atrioventricular canal development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within determination of heart left/right asymmetry IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lipid catabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2
Names
plcb2l
zfPLC-beta2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007128.7 Reference GRCz11 Primary Assembly

    Range
    2335547..2427807 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068214665.1 → XP_068070766.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2

    UniProtKB/TrEMBL
    A0A8M9P9T2
Nucleotide Protein Strain
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