tfb2m transcription factor B2, mitochondrial [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: tfb2mprovided by ZNC
Official Full Name: transcription factor B2, mitochondrialprovided by ZNC
Primary source: ZFIN:ZDB-GENE-070521-3
See related: Ensembl:ENSDARG00000074756 AllianceGenome:ZFIN:ZDB-GENE-070521-3
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: sb:cb857
Summary: Predicted to enable mitochondrial transcription factor activity and rRNA (adenine-N6,N6-)-dimethyltransferase activity. Predicted to be involved in rRNA methylation and transcription initiation at mitochondrial promoter. Predicted to act upstream of or within methylation and rRNA modification. Predicted to be active in mitochondrial matrix. Is expressed in several structures, including alar plate midbrain region; immature eye; mesoderm; midbrain; and optic primordium. Orthologous to human TFB2M (transcription factor B2, mitochondrial). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 17

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	17	NC_007128.7 (12058468..12073356)
105	previous assembly	GRCz10 (GCF_000002035.5)	17	NC_007128.6 (11904402..11919290)

Chromosome 17 - NC_007128.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables mitochondrial transcription factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables rRNA (adenine-N6,N6-)-dimethyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables rRNA (adenine-N6,N6-)-dimethyltransferase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within methylation	IEA Inferred from Electronic Annotation more info
involved_in rRNA methylation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within rRNA modification	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within rRNA processing	IEA Inferred from Electronic Annotation more info
involved_in transcription initiation at mitochondrial promoter	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in mitochondrial matrix	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: dimethyladenosine transferase 2, mitochondrial

NP_001107089.2

EC 2.1.1.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001113617.2 → NP_001107089.2 dimethyladenosine transferase 2, mitochondrial precursor

Status: VALIDATED

Source sequence(s)

BX470113, EH461916, EH486004, EH580492

UniProtKB/TrEMBL

A0A8M1NFT6, B7ZVD7

Related

ENSDARP00000123820.1, ENSDART00000150209.3

Conserved Domains (2) summary

cl17173
Location:112 → 415

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

cl21455
Location:41 → 113

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases