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Adam4 a disintegrin and metalloprotease domain 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 57022, updated on 27-Nov-2024

Summary

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Official Symbol
Adam4provided by RGD
Official Full Name
a disintegrin and metalloprotease domain 4provided by RGD
Primary source
RGD:621470
See related
AllianceGenome:RGD:621470
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
tMDCV
Summary
Predicted to enable metalloendopeptidase activity. Predicted to be involved in male gonad development and proteolysis. Predicted to be active in external side of plasma membrane and sperm head plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See Adam4 in Genome Data Viewer
Location:
6q24
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (106854533..106856979, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (101123284..101125730, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (105158024..105160470, complement)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 8 member A3 Neighboring gene uncharacterized LOC120103571 Neighboring gene uncharacterized LOC134479222 Neighboring gene cytochrome c oxidase assembly factor COX16 Neighboring gene a disintegrin and metallopeptidase domain 4-like 1 Neighboring gene uncharacterized LOC134479224 Neighboring gene synaptojanin 2 binding protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Rat MDC family of proteins: sequence analysis, tissue distribution, and expression in prepubertal and adult rat testis. Frayne J, et al. Mol Reprod Dev, 1997 Oct. PMID 9291465
  2. Chromosomal assignment of four testis-expressed mouse genes from a new family of transmembrane proteins (ADAMs) involved in cell-cell adhesion and fusion. Cho C, et al. Genomics, 1996 Jun 15. PMID 8786143
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC125044

General protein information

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Preferred Names
a disintegrin and metalloprotease domain 4
Names
a disintegrin and metalloprotease domain (ADAM) 4
tMDC V

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020305.1 → NP_064701.1  a disintegrin and metalloprotease domain 4 precursor

    See identical proteins and their annotated locations for NP_064701.1

    Status: PROVISIONAL

    Source sequence(s)
    BC107437
    UniProtKB/TrEMBL
    Q3B7V9
    Conserved Domains (5) summary
    smart00050
    Location:427 → 501
    DISIN; Homologues of snake disintegrins
    smart00608
    Location:503 → 644
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:213 → 405
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam01421
    Location:213 → 394
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:60 → 163
    Pep_M12B_propep; Reprolysin family propeptide

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    106854533..106856979 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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