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pcsk1nl proprotein convertase subtilisin/kexin type 1 inhibitor, like [ Danio rerio (zebrafish) ]

Gene ID: 570305, updated on 4-Jan-2025

Summary

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Official Symbol
pcsk1nlprovided by ZNC
Official Full Name
proprotein convertase subtilisin/kexin type 1 inhibitor, likeprovided by ZNC
Primary source
ZFIN:ZDB-GENE-090427-2
See related
Ensembl:ENSDARG00000076170 AllianceGenome:ZFIN:ZDB-GENE-090427-2
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
uo:ion003; wu:fj32g06
Summary
Enables serine-type endopeptidase inhibitor activity. Predicted to act upstream of or within negative regulation of endopeptidase activity. Is expressed in adenohypophyseal placode; nervous system; and pancreas. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See pcsk1nl in Genome Data Viewer
Location:
chromosome: 8
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (7359292..7379391)
105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (7340561..7360660)

Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene glutamate receptor interacting protein 2a Neighboring gene ssu-2 homolog, related sequence 1 Neighboring gene selenoprotein H Neighboring gene histone H3-like centromeric protein A Neighboring gene LHFPL tetraspan subfamily member 4b Neighboring gene histone deacetylase 6 Neighboring gene GATA binding protein 1b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Identification of proSAAS homologs in lower vertebrates: conservation of hydrophobic helices and convertase-inhibiting sequences. Kudo H, et al. Endocrinology, 2009 Mar. PMID 18948394, Free PMC Article
  2. Knockdown of Carboxypeptidase A6 in Zebrafish Larvae Reduces Response to Seizure-Inducing Drugs and Causes Changes in the Level of mRNAs Encoding Signaling Molecules. Lopes MW, et al. PLoS One, 2016. PMID 27050163, Free PMC Article
  3. Peptidomics of the zebrafish Danio rerio: In search for neuropeptides. Van Camp KA, et al. J Proteomics, 2017 Jan 6. PMID 27705817
  4. Characterization of Intracellular Peptides from Zebrafish (Danio rerio) Brain. Teixeira CMM, et al. Zebrafish, 2019 Jun. PMID 31017557
  5. Identification of differentially expressed genes in the zebrafish hypothalamic-pituitary axis. Toro S, et al. Gene Expr Patterns, 2009 Apr. PMID 19166982, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Both zebrafish and Xenopus proSAAS exhibited neural and endocrine distributions.
    Title: Identification of proSAAS homologs in lower vertebrates: conservation of hydrophobic helices and convertase-inhibiting sequences.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
enables serine-type endopeptidase inhibitor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within negative regulation of endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
proprotein convertase subtilisin/kexin type 1 inhibitor, like
Names
proSAAS

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001166129.1 → NP_001159601.1  proprotein convertase subtilisin/kexin type 1 inhibitor, like precursor

    Status: VALIDATED

    Source sequence(s)
    BX469901
    UniProtKB/TrEMBL
    A0A8M1NSU7, F1QCH5
    Related
    ENSDARP00000109911.2, ENSDART00000121708.3

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007119.7 Reference GRCz11 Primary Assembly

    Range
    7359292..7379391
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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