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PLAAT1 phospholipase A and acyltransferase 1 [ Homo sapiens (human) ]

Gene ID: 57110, updated on 27-Nov-2024

Summary

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Official Symbol
PLAAT1provided by HGNC
Official Full Name
phospholipase A and acyltransferase 1provided by HGNC
Primary source
HGNC:HGNC:14922
See related
Ensembl:ENSG00000127252 MIM:606487; AllianceGenome:HGNC:14922
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
A-C1; HRSL1; HSD28; HRASLS; HRASLS1; PLA/AT1; PLAAT-1; H-REV107
Summary
Enables acyltransferase activity, transferring groups other than amino-acyl groups and phospholipase activity. Involved in N-acylphosphatidylethanolamine metabolic process and phosphatidylcholine metabolic process. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in testis (RPKM 17.3), thyroid (RPKM 1.8) and 3 other tissues See more
Orthologs
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Genomic context

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See PLAAT1 in Genome Data Viewer
Location:
3q29
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (193240606..193281426)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (195935989..195976800)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (192959011..192988644)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene ReSE screen-validated silencer GRCh37_chr3:192542821-192542997 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20992 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20993 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20994 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20995 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20996 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20997 Neighboring gene Mab-21 domain containing 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20998 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20999 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:192632483-192632983 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21000 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15007 Neighboring gene vascular endothelial zinc finger 1 pseudogene 1 Neighboring gene uncharacterized LOC105374280 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15008 Neighboring gene uncharacterized protein MGC2889 Neighboring gene ATP13A5 antisense RNA 1 Neighboring gene ATPase 13A5 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:193065706-193066384 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:193107044-193107612 Neighboring gene ATPase 13A4 Neighboring gene ATP13A4 antisense RNA 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The HRASLS (PLA/AT) subfamily of enzymes. Mardian EB, et al. J Biomed Sci, 2015 Oct 26. PMID 26503625, Free PMC Article
  2. Isolation, characterization, and chromosome mapping of a human A-C1 Ha-Ras suppressor gene (HRASLS). Ito H, et al. Cytogenet Cell Genet, 2001. PMID 11474175
  3. Effects of Lipid Metabolism-Related Genes PTGIS and HRASLS on Phenotype, Prognosis, and Tumor Immunity in Lung Squamous Cell Carcinoma. Lei K, et al. Oxid Med Cell Longev, 2023. PMID 36703911, Free PMC Article
  4. Molecular interaction between K-Ras and H-REV107 in the Ras signaling pathway. Han CW, et al. Biochem Biophys Res Commun, 2017 Sep 16. PMID 28743497
  5. Transcriptional and translational downregulation of H-REV107, a class II tumour suppressor gene located on human chromosome 11q11-12. Husmann K, et al. Oncogene, 1998 Sep 10. PMID 9771974

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Effects of Lipid Metabolism-Related Genes PTGIS and HRASLS on Phenotype, Prognosis, and Tumor Immunity in Lung Squamous Cell Carcinoma.
    Title: Effects of Lipid Metabolism-Related Genes PTGIS and HRASLS on Phenotype, Prognosis, and Tumor Immunity in Lung Squamous Cell Carcinoma.
  2. A novel molecular mechanism describing K-Ras and H-REV107 binding is suggested and insights into new K-Ras effector target drugs are provided.
    Title: Molecular interaction between K-Ras and H-REV107 in the Ras signaling pathway.
  3. The HRASLS (PLA/AT) subfamily of enzymes.
    Title: The HRASLS (PLA/AT) subfamily of enzymes.
  4. a possible enzyme activity of A-C1
    Title: Enzymological analysis of the tumor suppressor A-C1 reveals a novel group of phospholipid-metabolizing enzymes.
  5. The phospholipase active site possesses a structurally conserved Cys-His-His triad as found in NlpC/P60 peptidases, indicating H-REV107 should adopt a similar catalytic mechanism towards phospholipid substrates to that of NlpC/P60 peptidases.
    Title: Solution structure of the N-terminal catalytic domain of human H-REV107--a novel circular permutated NlpC/P60 domain.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables N-acyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables N-acyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables O-acyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables calcium-dependent phospholipase A2 activity IEA
Inferred from Electronic Annotation
more info
  
enables calcium-independent phospholipase A2 activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylserine 1-acylhydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables phospholipase A1 activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phospholipase A1 activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phospholipase A2 activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phospholipase A2 activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in N-acylphosphatidylethanolamine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in N-acylphosphatidylethanolamine metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in lens fiber cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in lipid catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in organelle disassembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in phosphatidylcholine metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in lysosome ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nuclear envelope lumen ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
phospholipase A and acyltransferase 1
Names
H-REV107 protein-related protein
HRAS like suppressor
HRAS-like suppressor 1
phospholipase A/acyltransferase 1
phospholipid-metabolizing enzyme A-C1
NP_001353041.1
NP_065119.3
XP_011511336.2
XP_011511337.2
XP_047304580.1
XP_047304581.1
XP_047304582.1
XP_054203328.1
XP_054203329.1
XP_054203330.1
XP_054203331.1
XP_054203332.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001366112.1 → NP_001353041.1  phospholipase A and acyltransferase 1

    Status: VALIDATED

    Source sequence(s)
    AC092966, AC105057
    Consensus CDS
    CCDS3303.3
    UniProtKB/Swiss-Prot
    D2KX19, Q6X7C0, Q86WS9, Q9HDD0, X6R3D1
    Conserved Domains (1) summary
    pfam04970
    Location:26 → 130
    LRAT; Lecithin retinol acyltransferase

  2. NM_020386.5 → NP_065119.3  phospholipase A and acyltransferase 1

    Status: VALIDATED

    Source sequence(s)
    BC048095, BX098792
    Consensus CDS
    CCDS3303.3
    UniProtKB/Swiss-Prot
    D2KX19, Q6X7C0, Q86WS9, Q9HDD0, X6R3D1
    Related
    ENSP00000264735.4, ENST00000264735.4
    Conserved Domains (1) summary
    pfam04970
    Location:26 → 130
    LRAT; Lecithin retinol acyltransferase

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    193240606..193281426
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047448626.1 → XP_047304582.1  phospholipase A and acyltransferase 1 isoform X5

    UniProtKB/Swiss-Prot
    D2KX19, Q6X7C0, Q86WS9, Q9HDD0, X6R3D1

  2. XM_011513035.3 → XP_011511337.2  phospholipase A and acyltransferase 1 isoform X2

  3. XM_011513034.2 → XP_011511336.2  phospholipase A and acyltransferase 1 isoform X1

  4. XM_047448625.1 → XP_047304581.1  phospholipase A and acyltransferase 1 isoform X4

  5. XM_047448624.1 → XP_047304580.1  phospholipase A and acyltransferase 1 isoform X3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    195935989..195976800
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054347357.1 → XP_054203332.1  phospholipase A and acyltransferase 1 isoform X5

    UniProtKB/Swiss-Prot
    D2KX19, Q6X7C0, Q86WS9, Q9HDD0, X6R3D1

  2. XM_054347354.1 → XP_054203329.1  phospholipase A and acyltransferase 1 isoform X2

  3. XM_054347353.1 → XP_054203328.1  phospholipase A and acyltransferase 1 isoform X1

  4. XM_054347355.1 → XP_054203330.1  phospholipase A and acyltransferase 1 isoform X3

  5. XM_054347356.1 → XP_054203331.1  phospholipase A and acyltransferase 1 isoform X4

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9HDD0.1 GenPept UniProtKB/Swiss-Prot:Q9HDD0

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